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The Twinkle Factory (@TwinkleFactory1) profile picture

The Twinkle Factory

@TwinkleFactory1

At The Twinkle Factory, we enjoy colorful, fluorescent, blinking, life sciences! Stain Different. Tag FAST.

 Paris, France
the-twinkle-factory.com
Joined September 2020
  • Tweets90
  • Following158
  • Followers70
1Media
Photo by The Twinkle Factory (@TwinkleFactory1)
The Twinkle Factory retweeted
Boris Vauzeilles (@BorisVauzeilles) profile picture
Boris Vauzeilles@BorisVauzeilles30 Mar 2025
Save the date! For the first time since 2015, the annual conference of the International Chemical Biology Society comes back to Europe and joins forces with the European Chemical Biology Symposium, to organize #ChemBioParis2025, in the heart of the City of Light. Oct 6-9, 2025
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The Twinkle Factory retweeted
Charlotte Crowe (@CharlCrowe) profile picture
Charlotte Crowe@CharlCrowe10 Oct 2024
The Centre for Targeted Protein Degradation @UoDCeTPD @alessiociulli is #recruiting. Join the team! 💪 dundee.ac.uk/work-for-us/job… #biophysics dundee.ac.uk/work-for-us/job… #medchem #chemjobs dundee.ac.uk/work-for-us/job… #chemicalproteomics
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Very happy to share our latest work on @angew_chem Great collaboration with Ewing @AndrewEwing11 and Peng@NJU. Well done Kele @kelechen_chem Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette - onlinelibrary.wiley.com/doi/…

Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette

We developed a synapse-mimicking nanopipette method to electrochemically monitor single vesicle dynamics induced by lipid-tau interactions. Characteristic ionic current oscillations have been used...

onlinelibrary.wiley.com
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Nanopore Weekly Meeting on 15 July, 2024 at 14.00 (CEST). We will have Professor Mihail Barboiu presenting Artificial Water Channels. Zoom Link: american-chemical-society.zo… Meeting-ID: 84644647831 #NanoporeElectrochemistry
Image from Yitao Long/Yi-Tao LONG Lab (@YTLong_Chem)
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Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation - Yim - ChemMedChem - Wiley Online Library chemistry-europe.onlinelibra…
Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation

Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation

To overcome the limitations of conventional PROTACs, conditional PROTACs have been developed. This review highlights recent strategies for modulating targeted protein degradation in spatio-, tempor...

chemistry-europe.onlinelibrary.wiley.com
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The Twinkle Factory retweeted
Guillaume Laconde (@Glaconde34) profile picture
Guillaume Laconde@Glaconde3412 Jul 2024
Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation - ChemMedChem - Wiley Online Library chemistry-europe.onlinelibra…
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It was great to discuss with experts on fluorescent biosensors Arnaud Gautier, Robert Campbell @Campbell_FPs and @joachimgoedhart after mini-symposium "Illuminating life with advanced fluorescent probes". Thanks Arnaud for the invitation!
Image from Andrey Klymchenko 🇺🇦 (@aklymchenko)
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Read this #preprint on @researchsquare: Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A researchsquare.com/article/r… #FAST #splitFAST #bioPROTAC #PROTAC

Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A

BioPROTACs are heterobifunctional proteins designed for targeted protein degradation (TPD). They are useful not only for probing protein functions but also offer a therapeutic avenue for modulating...

researchsquare.com
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A guide to genetically-encoded redox biosensors: state of the art and ... sciencedirect.com/science/ar…
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Teaching old dogs new tricks: genetic engineering methanogens | Applied and Environmental Microbiology journals.asm.org/doi/full/10…

Teaching old dogs new tricks: genetic engineering methanogens | Applied and Environmental Microbi...

The discovery of methane- (CH4-) producing microbes with DNA sequences distinct from bacterial DNA led to the establishment of Archaea as a new domain of life (1). Methanogens, which exhibit unique...

journals.asm.org
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Mandatory!
Joachim Goedhart (@joachimgoedhart) profile pictureJoachim Goedhart@joachimgoedhart27 May 2024
Join us for a minisymposium on "Illuminating life with advanced fluorescent probes" - July 11, 2024 in Paris - organized by Arnaud Gautier and @LinaElHajji1
Image from Joachim Goedhart (@joachimgoedhart)
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🌈 pushing #FAST and #splitFAST towards near infrared!🍭 A tunable and versatile chemogenetic near infrared fluorescent reporter biorxiv.org/content/10.1101/…
A tunable and versatile chemogenetic near infrared fluorescent reporter

A tunable and versatile chemogenetic near infrared fluorescent reporter

Near-infrared (NIR) fluorescent reporters provide additional colors for highly multiplexed imaging of cells and organisms, and enable imaging with less toxic light and higher contrast and depth....

biorxiv.org
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🌈 multiplexing FAST and splitFAST with FLIM 🍭 Multiplexed in vivo imaging with fluorescence lifetime modulating tags biorxiv.org/content/10.1101/…
Multiplexed in vivo imaging with fluorescence lifetime modulating tags

Multiplexed in vivo imaging with fluorescence lifetime modulating tags

Fluorescence lifetime imaging opens new dimensions for highly multiplexed imaging in live cells and organisms using differences in fluorescence lifetime to distinguish spectrally identical fluoresc...

biorxiv.org
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🌈 FAST and splitFAST powered 🍭 Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters biorxiv.org/content/10.1101/…
Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible...

Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible...

Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites and their small size hinder analysis by current imaging...

biorxiv.org
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🌈 FAST and splitFAST powered 🍭 Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs biorxiv.org/content/10.1101/…
Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

Interferon-inducible Myxovirus resistance 1 (MX1) proteins are well-known to restrict influenza A virus (IAV) at early stages during viral replication, impairing the viral transcription/replication...

biorxiv.org
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🌈 FAST & splitFAST powered 🍭 Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation biorxiv.org/content/10.1101/…
Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic...

Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic...

The spine apparatus (SA), an endoplasmic reticulum-related organelle present in a subset of mature dendritic spines, plays a key role in postsynaptic development and has been implicated in various...

biorxiv.org
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The Twinkle Factory retweeted
Dan Nomura (@DanNomura) profile picture
Dan Nomura
@DanNomura17 Mar 2024
Just arrived in Munich! Excited to hear great talks and present our latest research at the #GDCh Frontiers in Medicinal Chemistry Symposium! veranstaltungen.gdch.de/micr…
Image from Dan Nomura (@DanNomura)
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It was great to start the school on #fluorescence #markers for advanced #microscopy #fluorescenceleshouches with a fundametal talk by Ludovic Jillien.
Image from Andrey Klymchenko 🇺🇦 (@aklymchenko)
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🌈 and fluorogenic molecular glues for CATCHFIRE are available at the-twinkle-factory.com 🍭
The Twinkle Factory (@TwinkleFactory1) profile pictureThe Twinkle Factory@TwinkleFactory126 Nov 2023
🌈plasmids now available at @addgene 🍭 addgene.org/Arnaud_Gautier/
Addgene

Addgene

addgene.org
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🌈🌈 "controlling, imaging and sensing protein proximity" all together! Congrats! 🍭🍭 #CIP #proteindimerizer
Franck Perez (@Team_FranckP) profile pictureFranck Perez@Team_FranckP28 Aug 2023
Replying to @Team_FranckP
Bottone, S., Joliot, O., Cakil, Z.V. et al. A fluorogenic chemically induced dimerization technology for controlling, imaging and sensing protein proximity. Nat Methods (2023). doi.org/10.1038/s41592-023-0…
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