We study the ancestral function of genomic structural variants deleted in the human lineage using single-cell CRISPRi in chimpanzee cells biorxiv.org/content/10.1101/…
A short review/opinion I wrote with @brainevodevo, "identifying large-effect mutations–should they exist–and defining the effect size distribution for a measurable phenotype are central challenges facing genetic studies of human evolution” sciencedirect.com/science/ar…