Tom Vondriska (@VondriskaLab) header
Tom Vondriska (@VondriskaLab) profile picture

Chromatin, heart disease, and other stuff see thomasvondriska dot sub stack dot com

Los Angeles
Joined April 2020
Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)Photo by Tom Vondriska (@VondriskaLab)
America doesn't exist on the internet thomasvondriska.substack.comโ€ฆ
2
383
Tom Vondriska retweeted
Our new paper @CellReports, led by @katsu_s_minami et al.! ๐ŸŽ‰๐Ÿงฌ๐Ÿ”ฌ cell.com/cell-reports/fullteโ€ฆ Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin. Congrats!
3
24
86
3,413
Join Fred Hutch Cancer Center as a Bezos Family Distinguished Scholar in @HutchBasicSci. We're seeking a scientific leader advancing discoveries in immunotherapy, precision oncology, data science, or viruses & vaccines. Learn more and apply: apply.interfolio.com/193655
2
10
24
3,351
Tom Vondriska retweeted
Congrats Brewers Fans๐Ÿป Tip back some cold ones tonight, you deserve it!
62
957
57
7,220
234,108
Tom Vondriska retweeted
We are recruiting tenured Associate or Full Professor positions (100% FTE) in the field of cardiometabolic diseases. Click the link for more information & application details ๐Ÿ‘‡ aprecruit.ucr.edu/JPF02370
3
6
760
The deadline is nearing. Please consider applying.
๐Ÿ”” We are hiring! ๐Ÿ”” We are looking for great colleagues doing curiosity driven research at the molecular level across broad areas of science. Please consider applying and spread the word! recruit.apo.ucla.edu/JPF1130โ€ฆ
4
1
676
file this with: things self-evident that someone felt the need to publish on
"The ability to think about what is not happening is a cognitive achievement that comes at an emotional cost".
225
Tom Vondriska retweeted
American glass. American metal. American silicon. American batteries. American workers. American everything. BlueChip is the first American computer in decades. Don't let anyone lie to you and say it can't be done. Designed in California. Built in America.
BlueChip. Built in America. America made the first electronic computer to win a war. Now we depend on our greatest adversaries to build the computers that run our economy and defend our nation. Today, we bring it home.
1,379
4,417
414
49,957
1,378,686
An enjoyable read. My own view is that AI would provide a far superior review to human beings. In fact, I can think of no scenario in which a humanโ€™s review would be better. The problem of โ€˜AI hallucinationsโ€™ is a straw man: human hallucinations are far worse, oftentimes from โ€˜expertsโ€™ with the subject matter. AIโ€™s appraisal is corrected by improved data. That of many humans never can be. More broadly, on current trajectory, there will be no reason to publish original research papers in a couple years, maybe sooner (even now there should never be another review article written by humansโ€”thank god). The only way humans retain competitive advantage over AI is if we choose to heavily regulate it, like nuclear technology, and direct it towards eliminating the waste associated with research and medical care (which the authors correctly lament), rather than become another source increasing it. This seems to me an unlikely outcome, because of a collective action problem: right now, everyone is trying to get ahead with AI while still competing against other humans. Humans stand no chance in terms of novel discoveries, creative output and brute knowledge when competing directly against a super intelligent AI. Scientists will become like those who restore old cars or make furniture in their garages: an antiquated and inefficient, Luddite pursuit. Unnecessary. This transition will be painful for those of us entrenched in doing things the way we were taught, but afterwards who knows? One thing is certain: we will live long enough to see it happen.
Giving AI a seat at the peer review table OR AI as Reviewer 4? Nature Biotechnology (nature.com/articles/s41587-0โ€ฆ) Together with Aristotelis Tsirigos @artsinyc, we aim to open a dialogue on the responsible use of large language models and AI/SI in peer review. Rather than pretending reviewers do not use these tools, it is time to establish how to use them appropriately while safeguarding the confidentiality of manuscripts and grant applications. Drosatos, K., Tsirigos, A. Giving AI a seat at the peer review table. Nat Biotechnol (2026). doi.org/10.1038/s41587-026-0โ€ฆ
2
6
6,719
Tom Vondriska retweeted
Not too many pics go harder than this.
523
1,340
169
24,585
1,768,086
Tom Vondriska retweeted
Looking for a tenure-track position? The Department of Cell Biology is hiring! Submit your application by October 31. See link below for more information: jobs.utsouthwestern.edu/job/โ€ฆ
6
8
623
Tom Vondriska retweeted
The National Academy of Medicine welcomes 3 new UCLA faculty members, each chosen by their peers for major contributions to medical science, healthcare and public health. newsroom.ucla.edu/releases/3โ€ฆ
3
12
2,721
Tom Vondriska retweeted
One more reason to linger on campus a little longer. ๐ŸŒ… ๐Ÿ“ธ: jacobdardashti_ on Instagram
1
20
1
249
5,973
Tom Vondriska retweeted
Golden Eye! โญ๏ธ The Soft Spiny-tailed Gecko is a beautiful lizard that has lost so much of its heathland habitat around Perth ๐ŸฆŽ
12
177
6
1,728
12,710
Tom Vondriska retweeted
Excited to share our new publication on physical regulation of genome! Millisecond compression of cells may induce changes in chromatin accessibility, which can be targeted by guide RNA for more efficient CRISPR activation of genes in heterochromatin. Thanks to all team members!
This microfluidic device squeezes cells as they pass through, loosening their tightly packed DNA so CRISPR tools can reach and switch on genes to make cell reprogramming more efficient. ๐Ÿงซ๐Ÿงฌ ๐Ÿ”— ow.ly/WKyt5100kpB #ResearchPowersProgresss #CellReprogramming #CRISPR
2
5
16
1,639
It took us nearly a hundred years, but weโ€™re finally on Substack. Subscribe now to receive dispatches from booksellers, staff picks, book recs, treasures from our archives, our new podcast, and much more to come: buff.ly/xTR0Hte
2
6
29
1,501
Woodburn Hall turns 150 years old ๐ŸŽ‰ From the early years as a cadaver lab to the backdrop of countless campus memories. Woodburn Hall has remained the heart of campus for generations. ๐Ÿ’›๐Ÿ’™ Explore the history: go.wvu.edu/4gd9h
1
38
206
4,108
Nobel laureate @KarlDeisseroth came to neuroscience through words. His love of literature and writing drew him toward the human brain, and a required psychiatry rotation in medical school set him on the path to developing optogenetics. Here, he traces that journey.
21
202
18
929
63,025
Tom Vondriska retweeted
What distinguishes successful from failed reprogramming to iPSC? In this new preprint, part of our @IGVFConsortium efforts, we used single cell methylation, Hi-C, RNA and ATAC, and spatial RNA to answer this question biorxiv.org/content/10.64898โ€ฆ
4
26
3
91
6,573
Tom Vondriska retweeted
Choosing the scenic route, rain or shine. ๐ŸŒง๏ธ๐Ÿ’™ [Video description: A montage of UCLA campus scenes shows buildings, walkways, trees, and green lawns on a rainy, overcast day.]
7
1
61
2,386