@WackerLab
Joined October 2017
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Our latest work: As it turns out different positive allosteric modulators bind to different sites at the mu opioid receptor. Find out more in our @biorxivpreprint. biorxiv.org/content/10.1101/…
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A take on the current state of biased signaling in psychedelic action and psychedelic drug discovery by John McCorvy and I: Biased Signaling in Psychedelic Action | Annual Reviews - go.shr.lc/4lx1pLf

Biased Signaling in Psychedelic Action

Psychedelics show tremendous promise for treating psychiatric disorders and other illnesses, including pain and migraine. Despite decades of research, there is uncertainty which signaling mechanisms...

annualreviews.org
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science.org/doi/10.1126/scia…

Structural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A

Structures reveal how a serotonin receptor binds different G proteins and how an antipsychotic selectively activates one pathway.

science.org
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Job Alert! Open Postdoc position in membrane protein structural biology, molecular pharmacology @ drug discovery in New York. More info can be found here: wackerlab.com/
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Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s41586-0… Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature
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Asenapine as a potent TAAR1 agonist nature.com/articles/s41467-0… Congrats @NeuroStructure

Molecular basis of human trace amine-associated receptor 1 activation

Nature Communications - hTA1 is a drug target for several neuropsychiatric disorders. Using cryo-EM and pharmacological assays, the authors illuminate hTA1’s similarity to neurotransmitter...

nature.com
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Tetracyclic antidepressants potently activate serotonin receptors 5-HT1e and 5-HT1F, explaining some of their clinically observed effects. @NeuroStructure @martafilizola @biorxivpreprint @biorxiv_neursci biorxiv.org/content/10.1101/…

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin...

Serotonin (5-hydroxytryptamine, 5-HT) acts via 13 different receptors in humans. Of these receptor subtypes, all but 5-HT1eR have confirmed roles in native tissue and are validated drug targets....

biorxiv.org
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Also, here is our @biorxivpreprint on the structure and pharmacological properties of human TAAR1 biorxiv.org/content/10.1101/…

Molecular Basis of Human Trace Amine-Associated Receptor 1 Activation

The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its...

biorxiv.org
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Also, the lab is looking for a Postdoc conducting the type of research described in the paper: CryoEM, membrane protein function and pharmacology, drug discovery.
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Structural Studies and Drug Discovery of SLC4A1/AE1 with @SchlessingerLab published in @NatureSMB: nature.com/articles/s41594-0…
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Thanks to first author @CapperMichael and collaborators including @SchlessingerLab, we report 7 structures, uptake and computational assays. Our mechanistic work complements the beautiful AE1-erythrocyte complex architecture reported by @OliBClarke. biorxiv.org/content/10.1101/…

Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter

Anion Exchanger 1 (AE1, SLC4A1) is the primary bicarbonate (HCO3-) transporter expressed in erythrocyte membranes where it mediates transport of CO2 between lungs and other tissues via import/export...

biorxiv.org
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Sharing our @bioRxivpreprint of “Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter”, in which we reveal how AE1 binds and transports substrates, and how different drugs inhibit the transporter.
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I am currently looking for a motivated Postdoc to join our team to work on the structure and function of neurotransmitter receptors and transporters. Spread the word! More info on our lab webpage wackerlab.com
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Now someone give @JustinGEnglish a real job already!
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Congratulations to my former colleague Justin English for his new paper in cell cell.com/cell/fulltext/S0092…

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells

The VEGAS system is a platform for directed evolution, a method for engineering DNA sequences, in mammalian cells. The system is highly mutagenic, facile, and self-contained, requiring no in vitro...

cell.com
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cell.com/molecular-cell/full…

lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island...

Schertzer et al. studied relationships between long noncoding RNAs (lncRNAs) and Polycomb repressive complexes (PRCs) in mouse trophoblast stem cells. They found that genome architecture, lncRNA...

cell.com
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FDA Approves Ketamine Nasal Spray for Depression co-invented by the Icahn School of Medicine's Dean Dennis Charney. washingtonpost.com/health/20…

In biggest advance for depression in years, FDA approves novel treatment for hardest cases

The nasal spray works in a new way and is based on an old anesthetic, ketamine, that has been used as a party drug

washingtonpost.com
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I am truly honored to receive this award
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I guess I am a neuroscientist now sloan.org/fellowships/2019-F…
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The future of oral drug delivery......is swallowing tiny tortoises that sting? science.sciencemag.org/conte…
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