Associate Professor at MIT Chemistry and Core Member at Broad Institute of MIT and Harvard
Boston
Joined June 2018
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Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX
Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.
Xiao Wang retweeted
Thanks to everyone sharing in this moment!
I’m so grateful to my trainees & collaborators…
dlab.stanford.edu/group-memb…
(pic: optogenetics conference chairs, Tuscany)
Reading for all those asking:
for technical details: dlab.stanford.edu
for everyone: deisseroth.org/projections
Xiao Wang retweeted
Congratulations to our first #NobelPrize laureate of 2026 🎉
Early this morning Karl Deisseroth found out he was awarded this year's Nobel Prize in Physiology or Medicine.
He seems very happy with the news!
ALT Karl Deisseroth on the phone looking happy
Xiao Wang retweeted
Professor of Chemistry and Broad Institute Core Member Xiao Wang has been selected as the recipient of the 2027 Eli Lilly Award in recognition of her fundamental research in Biological Chemistry.
chemistry.mit.edu/chemistry-…
Xiao Wang retweeted
Voices of biotech research
Nature Biotechnology asks a selection of faculty about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications go.nature.com/4rSBl0g
Xiao Wang retweeted
As the subject of this Graduate Student Spotlight, Seth Furniss reveals the inconsequential superpower he’d love to have, the food he craves most often, the house he’d build with unlimited funds, and more.
chemistry.mit.edu/chemistry-…
Xiao Wang retweeted
Excited to share our new work on immune aging! We explored whether the liver could serve as a temporary "factory" to produce immune factors that decline with aging, potentially helping to rejuvenate aged immunity. @mircoscopy.
Xiao Wang retweeted
Deep-STARmap and Deep-RIBOmap are imaging-based sequencing platforms for profiling transcriptional and translational activity in thick tissue blocks. @WangXiaoLab @xsui98
nature.com/articles/s41592-0…
Xiao Wang retweeted
The July issue is live nature.com/nbt/volumes/43/is…
On the cover, Chen et al. have developed a precise chemo-enzymatic method to synthesize and modify protein-coding mRNA to optimize functionality and pharmacokinetics go.nature.com/47EXbfq
Xiao Wang retweeted
Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease?
Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)
Xiao Wang retweeted
Thrilled to share our latest preprint regarding STAgent, a multimodal AI agent for spatial transcriptomics.:
(1/9) Check our manuscript at: biorxiv.org/content/10.1101/…
and demo at: youtu.be/aEUop05RINY
Xiao Wang retweeted
NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/…
Xiao Wang retweeted
My postdoctoral work is finally out! Please consider retweeting.
I am very proud of this project. I want to thank my wonderful advisors @mbarnalab and @jkpritch and collaborators Theo Susanto, @xsui98, @WangXiaoLab, @spence_jeffrey_, and many others for a major team effort!
1/9
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen.2024.…
Xiao Wang retweeted
Thrilled to share the latest work out of my lab at @CellCellPress on neuropeptidergic neurons in the dorsal raphe that regulate satiation. (cell.com/cell/fulltext/S0092…). Led by Srikanth Chowdhury, Nachi Kamatkar, and Wendy Wang (from Xiao Wang's lab). Congrats to an incredible team!
Xiao Wang retweeted
"Biotechnologist and molecular biologist Xiao Wang seeks to understand the life cycle of cellular RNA"
Read our interview with @broadinstitute @MIT researcher Dr. Wang, one of our #50ScientistsThatInspire:
cell.com/news-do/50-inspirin…
ALT Quote by Dr. Wang: "Learn but eventually grow out of the existing dogmas in your field"
Congrats to the team led by talented graduate students @HongyuChenChem @LDangliang @AbhiAditham and critical contributions from everyone. Big thanks to our collaborators on the covid vaccine demo @mircoscopy @zhangf @TheXavierLab, funding from @OnoPharmaFound, Klarman Cell Observatory, Merkin Institute, and finally reviewers and @NatureBiotech
Also thanks so much for the news & view written by Bei Chen and Tao Pan commenting on this work and our previous multi-tail constructs rdcu.be/dURbC
Happy to share CAST as the "BLAST" tool for spatial omics, searching and aligning similar patterns across datasets while revealing their differences with prototype demo of querying new data against reference spatial atlas and comparative spatial studies👇rdcu.be/dULBj
