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Joined February 2022
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We are proud to announce our partnership with GenomOncology and Belay Diagnostics to accelerate clinical trial enrollment for CNS cancer patients. Through our partnership, users can move directly from genomic reports to the WeTrials platform to access a patient-friendly, simplified clinical trial interface aligned with a patient’s biomarker profile and pursue enrollment through a streamlined process. In this way, molecular insights lead to meaningful treatment opportunities—helping connect patients to innovative therapies and trials, while giving clinicians a seamless on-ramp to patient enrollment directly within their workflow. @Belay_Dx @genomoncology @DrAMansouri
CT first, then MRI. Why? Brain tumor imaging
CT is fast, so you often get one in the ER. MRI shows more detail without radiation, so it carries most of the follow-up. Dr. Alireza Mansouri explains.
wetrials.com/patients/brain-…
AI avatar and AI voice of Dr. Mansouri.
Is a "free" trial really free?
Trial activities are usually covered. Travel often isn't, and standard care goes through insurance. Dr. Vijay Agarwal on what to ask about costs early.
wetrials.com/patients/brain-…
Best in science. Not best for children. Pediatric trials
Pediatric cancers are rare, so a randomized trial can take over 10 years. Dr. Giselle Sholler explains how her team designs trials for children instead.
wetrials.com/patients/pediat…
After radiation ends, who notices the changes?
Once treatment visits slow down, families are often the first to notice changes. Dr. Laurie Minns on what GBM caregivers said they needed.
wetrials.com/patients/brain-…
When a brain tumor diagnosis makes everything feel urgent at once, try taking things one step at a time.
In the latest Caregiver Chronicles, Janet Fanaki shares why neurosurgeon Dr. Carlos Velasquez Rodriguez tells families to face each stage as it comes, instead of all at once.
Watch the full episode: youtube.com/watch?v=LVL79Q5C…
#CaregiverChronicles #Caregiving #BrainTumor #BrainCancer #CaregiverSupport #Anxiety #WeTrials
Ask your doctor this before your next scan
One question to ask your doctor before your next scan: is there a biomarker-driven trial for me? Dr. Alireza Mansouri explains why.
wetrials.com/patients/brain-…
AI avatar and AI voice of Dr. Mansouri.
Asked to pay for an experimental treatment?
Dr. Nader Sanai's general rule of thumb for brain tumor patients: if you have to pay for an experimental therapy, that's a red flag.
wetrials.com/patients/brain-…
WeTrials retweeted
Alireza Mansouri Emphasizes the Power of a Second Opinion After a Glioblastoma Diagnosis – WeTrials
@WeTrialshub
oncodaily.com/voices/alireza…
WeTrials retweeted
We previously reviewed the rule of fractionated radio surgery for post-operative cavity. We stated that the optimal number of fractions are yet to be determined. The new alliance phase 3 trial advances our knowledge re 3-5 fractions:
1-year surgical-bed control: 87% with fractionated vs 81% with single-fraction (p ≈ 0.046).
Median OS (secondary endpoint): 29 vs 20 months (HR ~0.66–0.69), favoring fractionated.
No significant increase in toxicity/radiation necrosis.
Presenters (including Ayal Aizer) have described postoperative fractionated SRS as the new standard of care for larger cavities.
🚨 Check out our latest article on the multi-disciplinary management of brain metastases published in @NatRevClinOncol 🚨 Huge team effort, laying out the latest developments while also highlighting how much gap still exists in the literature. go.nature.com/41GQt5W
@BrainTumorDoc @SahgalArjun @PDBrownOnc @UMDNsgyChair @BettegowdaMDPHD @SteveKalkanisMD @gminniti2012 @DKondziolkaCNS @jasonpsheehan @SSMahaseMD @NeuroAhmad @NBTStweets @IvyBrainTumCtr @theABTA @TumorSection
Why do kids with cancer still get 50-year-old drugs?
Some chemotherapy given to kids with cancer is 50 years old. Dr. Giselle Sholler explains why clinical trials are how newer drugs reach children.
wetrials.com/patients/pediat…
International Brain Tumor Awareness Week starts today. In 2024, an estimated 324,095 people worldwide were diagnosed with a malignant brain or CNS cancer. If your family is facing one, find trials, guides and support: wetrials.com/brain-cancer #BrainTumorAwarenessWeek
Just told "glioblastoma"? Send them this.
In most cases there's time to get a second opinion after a glioblastoma diagnosis. Dr. Alireza Mansouri explains what it can confirm and how to ask for one.
wetrials.com/patients/brain-…
AI avatar and AI voice of Dr. Mansouri.
Why can't everyone get the new drug? Trial randomization
Dr. Vijay Agarwal on telling hopeful families they have a 50% chance of getting the treatment, and why glioblastoma trials still work this way.
wetrials.com/patients/brain-…
WeTrials retweeted
A natural bacterial consortium (AUN: P. mirabilis + R. palustris) drove complete remissions in mouse models of solid tumors by triggering selective intratumoral thrombosis and necrosis.
It worked in both immunocompetent and immunocompromised hosts, including human xenografts, without relying on immune cell infiltration.
The bacteria colonize the tumor, form biofilms, induce local fibrin/platelet aggregation, collapse the vasculature, and exert direct oncolytic effects. Ratio is self-stabilizing and no genetic engineering was used.
All of this is mouse data. Live bacteria carry real risk of systemic infection or sepsis if they escape the tumor or dosing is off. The wrong ratio or excessive single doses were lethal in the reported experiments. No human data.
Worth testing in more accessible, localized solid tumors such as colon, where regional or intratumoral delivery might limit systemic exposure?
nature.com/articles/s41551-0…
#CancerResearch #Oncology #BacteriaTherapy
Anxiety is easier to manage when you planned for it before it showed up.
In the latest Caregiver Chronicles, Janet Fanaki explains how to map out scenarios, including an emergency, and share the plan with your care team.
youtube.com/watch?v=LVL79Q5C…
WeTrials retweeted
Here is a video explainer youtube.com/shorts/NSPVyWzGk…
SurVaxM missed the primary OS endpoint in the full newly diagnosed GBM cohort.
Phase 2b placebo-controlled, n=233 after Stupp. 22.8 vs 20.3 months (HR 0.75, p=0.076). Prespecified ≤65 group did separate (24.2 vs 20.2 months, HR 0.64, p=0.019). Analysis adjusted for MGMT and KPS only—no EOR shown. Need the paper.
Have a question about a diagnosis, a clinical trial, or where to find support? 💬
The WeTrials Assistant is in the bottom corner of every page on wetrials.com. Type your question in your own words, and it points you to plain-language answers and the right resources, without clicking through menus.
Try it at wetrials.com
General information only, not medical advice. Always talk with your care team.
#ClinicalTrials #Caregivers #PatientSupport #CancerSupport #Healthcare #WeTrials
WeTrials retweeted
FDA cleared Phase 2 for MT027, an allogeneic B7-H3-targeted CAR-T, in brain metastases from lung and breast cancer. This is the second Phase 2 clearance for the same product after recurrent glioblastoma. Delivery is local intracranial; the supporting WCLC data remain very small (responses in 2 of 3 evaluable).
en.prnasia.com/releases/apac… @WeTrialshub
Thank you @theABTA and everyone who connected with WeTrials during #ABTAConference2026.
We’re grateful for the conversations with patients, caregivers, advocates, clinicians, and organizations across the brain tumor community.
Our work continues beyond the conference, and we’re already looking forward to next year.
#BrainTumorAwareness #BrainTumorStrong #WeTrials
