The Weger-Lucarelli Lab (@WegerJames) profile picture

Asst. professor at Virginia Tech University. Interested in virus evolution and transmission. I also love sports, music, food and laughs :)

Blacksburg, VA
Joined June 2015
Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)Photo by The Weger-Lucarelli Lab (@WegerJames)
This was a big collaboration with tons of great people. I really hope we find new collaborative projects in the future @FerdinandRoesch @VignuzziLab @SalehLabParis and everyone else
Replying to @FerdinandRoesch
Massive thanks to all our collaborators for their help and for not giving up on this cool project after COVID hit: @VignuzziLab & @SalehLabParis for hosting me as a postdoc & for their contibued support; @WegerJames for taking the lead on this after I moved to @INRAE_VDL;
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The Weger-Lucarelli Lab retweeted
Massive thanks to all our collaborators for their help and for not giving up on this cool project after COVID hit: @VignuzziLab & @SalehLabParis for hosting me as a postdoc & for their contibued support; @WegerJames for taking the lead on this after I moved to @INRAE_VDL;
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Congrats man! Super excited to collaborate in the future.
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The Weger-Lucarelli Lab retweeted
Please RT: 🦠Interested in Mosquito-Virus Interactions?🦟 I'm looking for a postdoc to work on the interactions between #Aedes mosquitoes and #arboviruses at the single-cell level @institutpasteur in Paris! Please find out more here ⏬ research.pasteur.fr/en/job/p… #postdocjobs
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The Weger-Lucarelli Lab retweeted
Our most recent article now online! Check out our work on #SARSCoV2 in collaboration with @WegerJames Lab! @Biochem_Anne @virginia_tech
Now online! A change within the Spike protein of #SARSCoV2 shows higher binding affinity to hACE2 and enhanced replication in human lung cells bit.ly/2SOAray For all @CellPressNews #coronavirus research and commentary, visit cell.com/2019-nCOV #COVID19
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The Weger-Lucarelli Lab retweeted
Some super cool work with @WegerJames and collaborators is now online in Cell! Analyzing 180K for selective sweeps and connecting it to structural data highlighted a mutation (T372A) that likely contributed to #SARSCoV2 emergence. 👇👇👇
Now online! A change within the Spike protein of #SARSCoV2 shows higher binding affinity to hACE2 and enhanced replication in human lung cells bit.ly/2SOAray For all @CellPressNews #coronavirus research and commentary, visit cell.com/2019-nCOV #COVID19
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Please check out our new publication that uses a cool technique to identify a mutation that likely was necessary for SARS-CoV-2 emergence into humans. Great collaboration with @Biochem_Anne @Biochem_Amanda @Opiniomics Lin Kang and others.
Now online! A change within the Spike protein of #SARSCoV2 shows higher binding affinity to hACE2 and enhanced replication in human lung cells bit.ly/2SOAray For all @CellPressNews #coronavirus research and commentary, visit cell.com/2019-nCOV #COVID19
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The Weger-Lucarelli Lab retweeted
Pateando genes 🎧 Un podcast para desentrañar los misterios de la biología. 🎙️ Gonzalo Moratorio ▶️ magnoliopodcast.uy/pateandog… 𝗠𝗮𝗴𝗻𝗼𝗹𝗶𝗼 𝗣𝗼𝗱𝗰𝗮𝘀𝘁, otra forma de escuchar.
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The Weger-Lucarelli Lab retweeted
Very excited to share the preprint of our SARS-CoV-2 ISG CRISPR/Cas9 screen. It was a huge collaborative effort led by Alice Mac Kain, PhD student in the @VignuzziLab with help from @lab_jouvenet @Virus_Immunity @SEBNisole @ArhelNathalie @MollyOhainle @SimonLoriereLab.Thread 1/10
Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen biorxiv.org/cgi/content/shor… #bioRxiv
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The Weger-Lucarelli Lab retweeted
Excited to share our newest paper! We demonstrate an effective forward genetics strategy to identify causal genes in Aedes aegypti mosquitoes 🦟biorxiv.org/cgi/content/shor…
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Check out @verorezelj's new paper! rdcu.be/ciOaR She finds cool defective viral genomes that are antiviral in mice and mosquitoes! Honored to have been involved and to have worked with @verorezelj + rest of @VignuzziLab! Pic: Denmark trip to analyze some of these data!
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The Weger-Lucarelli Lab retweeted
Because we rise by lifting others... Happy International Women's Day! #IWD2021 #internationalwomensday2021 #WomenInScience
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Hey, #ScienceTwitter! We're looking for a postdoc! Ideal traits include a positive attitude, self-motivation, and a strong immunology background. Our goal is to define mechanisms underlying increased disease severity observed during alphavirus infection in obese hosts. Thanks!!!
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Thanks @ElEarlyBird @profvrr for reviewing our paper! I will try to address your comments as reviewers 4 and 5 :)
The 1st live-streamed #TWiEVO episode 65 now recorded and up with links at microbe.tv/twievo/twievo-65/… Looking at a mutation in SARS2 with a proposed role in early stage adaptation to humans and discussing some late-breaking variants of interest and concern
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Please have a look at our new preprint! We may have identified an amino acid in the Spike of SARS-CoV-2 that was necessary for emergence into humans. A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation biorxiv.org/content/10.1101/…
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The Weger-Lucarelli Lab retweeted
Our work on chikungunya defective viral genomes piloted by MD-PhD student @LeviLevilaura and the Vignuzzi-Saleh megalab is now out! @VignuzziLab @SalehLabParis @institutpasteur also starring @verorezelj @WegerJames @LuciaCarrau @dianacerazoq @yasutsuzuki
Maria-Carla Saleh, @VignuzziLab and colleagues @institutpasteur describe the defective viral genomes arising during #CHIKV infection in vitro in mammalian and mosquito cells, and in vivo in experimentally infected #Aedes aegypti mosquitoes buff.ly/2YZ5hwH
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Obesity doesn't only lead to poor outcomes in #COVID19. Lots of epidemiological data suggest obesity results in worse outcomes following infection with #Dengue virus, which infects 300 million people annually. Here are some lab studies to back that up. rdcu.be/b6vCP
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#PLOSPathogens: Host nutritional status... dx.plos.org/10.1371/journal.… Excited to share our new paper on the role of nutrition on alphavirus disease severity, transmission, and evolution! A great collaboration with all of the great people @institutpasteur in the @VignuzziLab !
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The Weger-Lucarelli Lab retweeted
I'll be presenting my poster later today (P53), come check it out if you want to learn how @LuciaCarrau and myself from the @VignuzziLab are trying to identify mutations that may favor #Mayaro Virus emergence. We're pretty excited about our preliminary results! #MosquitoMeeting
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