Of course I disagree. You offered a biochemical answer and missed the biophysics reality. When you dismiss the water dielectric constant based purely on the poor water-solubility of anesthetics is a fundamental biophysical mistake that treats protein structures as if they exist in a vacuum. While anesthetics preferentially partition into the non-polar, hydrophobic pockets of tubulin, their very entry into these pockets is thermodynamically driven by their exclusion from the highly polar aqueous phase surrounding the microtubule. Microtubules are not dry structures, yet your reply acts like they are; they are highly charged polyelectrolytes completely encased in an asymmetric, ultra-ordered, and highly polarized layer of interfacial water molecules. This constrained water layer collapses the local relative dielectric constant from its bulk value of 80 down to approximately 9 right at the protein interface, establishing the precise electromagnetic boundaries required for microtubules to function as transmission lines for electrical and acoustic oscillations. On these grounds alone your theory collapses. And the data on this is overwhelming. By inserting themselves into the protein-water boundary, anesthetics directly disrupt the collective organization and phase transitions of this interfacial water. To argue that water's dielectric properties have nothing to do with anesthesia ignores the fact that shifting the local dielectric constant fundamentally alters the electromagnetic shielding, the capacitance, and the localized electric fields that govern the entire structural and vibrational state of the microtubule itself. Stu you have to be better than this.