Witte Lab

GWAS and TWAS analyses of 28 antigens for 16 viruses uncover associations outside of the HLA region, including genes in pathways implicated in cancer susceptibility and immunotherapy.

This panel includes 7,034 coding and noncoding variants without a priori patient-specific tumor mutation information, and uses UMIs to suppress technical errors arising from library prep and sequencing.

@johnwitte presents a summary of recent @WitteLab PRS work at #BoG2020. If you are interested in discussions of PRS transferability in non-European and admixed populations visit #poster65 by PhD student @taylorbcavazos

Witte Lab Retreat 2019 - hike to Alamere falls 🌊🚐

Great talk by @Linda_Kachuri highlighting the interplay between PRS, family history, and modifiable risk factors across cancer. #ASHG19 #ASHGtrainee @UCSF_Epibiostat

Congrats to Kevin Keys (@_klkeys_ ) on being a semi-finalist and your excellent talk today!

A big congratulations to @WitteLab post doc @Linda_Kachuri for receiving the Epstein award! Head to Session #49 to learn about her pan-cancer @uk_biobank analysis #ASHG19 #ASHGtrainee @UCSFCancer @UCSF_Epibiostat

Don't miss the chance to talk with @WitteLab post doc Travis Meyers (poster #2826) today from 3-4pm about his GWAS of autoimmune thyroid disease. @UCSF_Epibiostat #ASHG19 #ASHGtrainee

Visit @WitteLab PhD student, Taylor Cavazos at her poster (#2259) today from 2-3pm to discuss polygenic risk score performance in admixed individuals! @UCSFGradDiv @ucsfipqb #ASHG19 #ASHGtrainee

We are hiring! Opportunities for statistical genetics, genetic epidemiology, and cancer genomics. 🧬 Looking for a highly motivated and enthusiastic person to join our team! See job posting attached.

Congratulations to Amgen Scholar @MaikeMorrison for completing her summer project: GWAS of immune response to common pathogens in the @uk_biobank! We wish her all the best as she enters her final year of undergrad and applies to grad school! #2019sfsrtp @AmgenFoundation

Finally, TWAS associations were functionally interrogated to elucidate epigenetic mechanisms of prostate cancer risk through multi-omic analyses, including TFBS allele specific binding, pathway analysis, epigenetic cross-comparison to patient data, and Hi-C interactions (Fig 4).

In particular, imputed expression levels of TMPRSS2 in normal prostate tissue were associated with elevated prostate cancer risk, suggesting a novel germline-somatic interaction effect at the 21q22.3 locus (Fig 3b).

A big congrats to Jean Costello of @WitteLab and @Jelliffe_Pawlow lab for passing her qualifying exam on preterm birth risk factors! @ucsfipqb @UCSFPTBI

Sharing advances in polygenic risk scores @illumina!

PhD student @emmalyn_Chen of @WitteLab supporting @UCSF @UCSFGradDiv in Sacramento with Dean Elizabeth Watkins for the 10th Annual UC Graduate Research Advocacy Day!

Happy holidays from the Witte lab!

Celebrating the return of Dr. Elizabeth Blackburn to UCSF. @UCSF @UCSFCancer @Linda_Kachuri @ChenanZhang