adic

COOL FACTS ABSOLUTELY NO ONE HAS CARED ABOUT THIS WEEK (ZERO POLITICS, ZERO SCIENCE DRAMA, ZERO AI, ZERO NEGATIVITY) while I avoid packing: -FREAKING NEURONS make the aggrecans/proteoglycans for their own perineuronal nets NOT GLIA and it's predominantly inhibitory neurons BUT it has to be expressed by excitatory neurons in order for critical period closure -XIST (x inactive specific transcript) that keeps the second X inactive (but like only partially and dynamically depending on tissue type) is PROTEIN CODING IN BIRDS AND FISH AND IN FISH IT CONTROLS DEVELOPMENTAL AXES VIA AN E3 LIGASE -sometimes cancer cells just pop a tumor suppressor onto the inactive x and xist just zambonis over that nonsense in cis -WE OWE LIKE OUR ENTIRE UNDERSTANDING OF RNA BIOLOGY FROM SPLICING TO THE SPLICEOSOME TO SOME TRNA STUFF TO NUCLEOLAR BIOLOGY TO AUTOIMMUNE PATIENTS PROVIDING THEIR SERA IN THE 70S AND 80S FOR AUTOANTIBODIES AGAINST THE RELEVANT RIBONUCLEOPROTEINS -the original cells ANA tests were used on were HEp-2 cells which turned out to be HeLa cells the whole time and do absolutely fucked things with their sex chromosomes I'm not rereading for typos, yolo