Passionate about GU Oncology | Royal College of Surgeons alumnus | Interested in proteogenomics and liquid biopsies 🇪🇬🇺🇸
MN
Joined January 2011
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Thank you, @EAntonarakis ! Truly honored and grateful to @PCF_Science and the Milken Family Foundation. Thank you for your mentorship, alongside Justin Hwang and @DrJustinDrake , and to the patients who make this work possible. Excited for what's ahead! @UMNCancer
Congrats to our newest PCF Young Investigator from Minnesota, the one-and-only Dr. Ali Arafa @aliarafaa. @UMNCancer @UMNews @ThePCCTC @PCF_Science
We profiled extracellular vesicles in plasma and identified proteins associated with treatment outcomes in men with advanced prostate cancer treated with 177Lu-PSMA-617. This work would not have been possible without the mentorship and guidance of @EAntonarakis @DrJustinDrake
Congrats @aliarafaa and @DrJustinDrake for your elegant work on plasma extracellular vesicle (EV) proteomics in Pluvicto-treated prostate cancer patients. Blood-based detection of PSMA, B7-H3, STEAP1 and Trop2 will help precision therapeutics! @UMNCancer cell.com/cell-reports-medici…
Excited to share our prostate cancer proteomics work, initially presented at #ASCO25, is now featured on @VuMedi! Grateful for the chance to share how liquid biopsy biomarkers may help shape the future of personalized therapy. @UMNCancer @MPaT_PHCL_UMN
vumedi.com/video/ascor-2025-…
Ali Arafa retweeted
Congratulations @aliarafaa on developing the first prognostic blood-based PROTEOMIC biomarker for 177Lu-PSMA-617 efficacy, presented at ASCO ‘25. @UMNCancer @UMNews meetings.asco.org/abstracts-…
ATM mutated tumors lack TP53 mutations, while gBRCA1-mutated tumors were enriched for TP53, suggesting synthetic essentiality. ATM-dependent cancers rely on intact TP53, opening new therapeutic vulnerabilities. Disrupting TP53 or inhibiting ATM could unlock targeted treatments!🚀
Largest study of BRCA-associated cancers (24,309) shows that somatic tumor landscape is influenced by germline HRR muts: gBRCA1-altered cancers are enriched in somatic TP53 muts; gATM-altered cancers are depleted in TP53 mut. Congrats @aliarafaa @umncancer aacrjournals.org/clincancerr…
A huge thank you to @EAntonarakis & Justin Hwang for the mentorship and support. Thank you @TempusAI for making this happen.
I am really grateful for my mentors, @EAntonarakis @DrJustinDrake for their support and guidance! A huge thank you to the American Cancer Society @ACS_Research for funding my fellowship! 2025 and 2026 will be great for blood based proteomics!
Congrats @aliarafaa for developing a new method for robust plasma exosome proteomics capable of detecting and quantifying >5000 proteins incl. PSMA, B7H3, TROP2 and STEAP1. A new blood-based biomarker is born! @UMNews mdpi.com/2072-6694/16/24/426…
Our multi-omics study highlights the unique biology of AMPC, a potential precursor to NEPC, with implications for early therapeutic targeting. FOXA1 and OTX2 may play crucial roles! @DrJustinDrake @EAntonarakis @MPaT_PHCL_UMN @UMNCancer
Amphicrine prostate cancer may be a transitional state between prostate adenoCa and small cell/NEPC. Upregulation of FOXA1 and OTX2 may play a role. Congrats to Megan Ludwig for this deep multi-omic analysis. @UMNCancer @umn_dom @DrJustinDrake @aliarafaa nature.com/articles/s41698-0…
Ali Arafa retweeted
Congratulations to new @AmericanCancer postdoctoral fellow, @aliarafaa. His project addresses an important clinical problem - identifying biomarkers of response to Pluvicto among men receiving treatment for castration resistant metastatic prostate cancer. Thank you and good luck!
I'm thrilled to share that I have been awarded an @AmericanCancer Postdoctoral Fellowship for my prostate cancer research. Many thanks to the prostate cancer team @DrJustinDrake @EAntonarakis @scottdehm and @MPaT_PHCL_UMN for their invaluable support.
I'm thrilled to share that I have been awarded an @AmericanCancer Postdoctoral Fellowship for my prostate cancer research. Many thanks to the prostate cancer team @DrJustinDrake @EAntonarakis @scottdehm and @MPaT_PHCL_UMN for their invaluable support.
Ali Arafa retweeted
Congrats @aliarafaa for delivering your first Oral ASCO Abstract. Your impactful study shows that germline mutations clearly influence somatic mutation landscapes in BRCA-associated cancers. ascopubs.org/doi/abs/10.1200…
Ali Arafa retweeted
Abstr 10509: Largest study examining the somatic genomic landscape of tumors developing in germline HRR mutation carriers versus sporadic cancers. Congrats @aliarafaa for your first ASCO Oral presentation. Thanks to @TempusLabs for this rich data set. meetings.asco.org/abstracts-…
Humbled to be featured in the March/April edition of Prostatepedia @NASPCC1. I had the opportunity to discuss the impact of the PSMA PET scan on clinical decision-making, current clinical trials, biomarkers, and targeted therapies.
online.flippingbook.com/view…
Thanks to @EAntonarakis & @DrJustinDrake for their mentorship, guidance, and support. It wouldn't have been possible without your help!
Ali Arafa retweeted
Effect of germline mutations on somatic alteration landscapes in BRCA-associated cancers [2023] @aliarafaa et al. @EAntonarakis #ASCO23 Abst #10509 meetings.asco.org/abstracts-… #PrecisionMedicine #geneticcounselors @UMNews @hopkinskimmel @TempusLabs
Extremely honored to announce that my very first
@ASCO abstract has been accepted for an oral presentation as part of a clinical science symposium! I am very grateful for the mentorship and guidance of
@EAntonarakis. Thank you @TempusLabs for making this happen!! #ASCO23
