Marie-Charlotte (@allichonmc) header
Marie-Charlotte (@allichonmc) profile picture

Marie-Charlotte

@allichonmc

👩🏼, rider 🐎 and neuroscientist at @PittPsychiatry Joffe lab 🇺🇸 l opioid addiction, GPCR, PFC l PhD from 🇫🇷 @Sorbonne_Univ_ Vanhoutte lab

 Paris
Joined June 2015
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  • Followers160
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Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)Photo by Marie-Charlotte (@allichonmc)
Marie-Charlotte retweeted
Annegret Falkner (@Neurrriot) profile picture
Annegret Falkner@NeurrriotNov 2
Maybe my favorite thing we have done yet! Estrogen oscillates network dynamics in the female PFC between rigid and flexible states. Seems like something basic/fundamental we should know already, but somehow we don't 🙃
Meenakshi Asokan (@MeenaMav94) profile pictureMeenakshi Asokan@MeenaMav94Oct 31
So excited to share my postdoctoral work!! How do hormones that fluctuate over hours to days reshape neural computations that guide social decisions? In this study, we investigated how estrogen alters cortical dynamics during social choice in female mice: doi.org/10.64898/2026.10.25.…
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🚨 New review out! We summarize how MOR and NOPR exert divergent , cell-type-specific control over VTA-NAc-PFC circuits in opioid use disorder frontiersin.org/articles/10.…
Frontiers | Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the...

Frontiers | Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the...

The mu-opioid receptor (MOR) and the nociceptin/orphanin FQ receptor (NOPR) are closely related yet functionally distinct modulators of rewards, motivation, ...

frontiersin.org
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Early life stress rewires emotional circuits (but also sensory ones)! New work from the Rosen lab shows ELS during the auditory critical period alters 5-HT3R–expressing VIP & NDNF interneurons, linking 5-HT signaling to lasting sensory dysfunction🧠 👉doi.org/10.1016/j.ynstr.2026…
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Replying to @npp_journal @sanjo234 @Phi_hD @Rene_Hen @sameerjauhar @jessi_maltman @jgmaeso @Mananar2468 @nastasiayendiki @Haber_Lab @BrentForester
#ThisWeekInNPP Kallupi et al. use large-scale phenotyping of rats 🐀 to unveil genetic variants underlying susceptibility to opioid use disorder @kallupi_marsida @SierraSimpson @neuroselo @esneddon21 @abepalmer.bsky.social @brainaddiction nature.com/articles/s41386-0…
Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock...

Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock...

Neuropsychopharmacology - Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like...

nature.com
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Marie-Charlotte retweeted
ACNP (@ACNPorg) profile picture
ACNP@ACNPorg10 Nov 2025
We are proud to announce ACNP's NPP Journal award winners! Dhvani D. Mehta, B.Sc. (NEATOR Award), John H. Krystal, M.D. (NEAR Award), and Max E. Joffe, Ph.D. @mejoffe (NEECA Award) @npp_Journal, #ACNP2026
Image from ACNP (@ACNPorg)
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The neural circuits and signalling pathways of opioid use disorder — a Review by Victor P. Mathis, Aliza T. Ehrlich & Emmanuel Darcq @Victor_Mathis_ @EhrlichAliza @EDarcq nature.com/articles/s41583-0…
The neural circuits and signalling pathways of opioid use disorder

The neural circuits and signalling pathways of opioid use disorder

Nature Reviews Neuroscience - In many parts of the world, opioid use disorder presents a growing challenge to public health, reinforcing the need to decipher its underlying mechanisms. Mathis et...

nature.com
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Marie-Charlotte retweeted
X. William Yang (@XWilliamYang1) profile picture
X. William Yang@XWilliamYang11 Nov 2025
Happy to share our paper creating an atlas of the dendritic morphology of D1- and D2-MSNs and elucidating its organizational principle. Thanks to Chris Park, Ming Yan, Masood Akram, Hongwei Dong, Daniel Tward, and others. Funding from US BRAIN Initiative. share.google/AAi82f52oIBXvFD…
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Happy to share our latest study !! journals.plos.org/plosbiolog… We show that behavioral inflexibility is linked to reduced mGluR5 signaling capacity in the dorsolateral striatum, where mGluR5 engages distinct intracellular pathways to regulate tLTD in iSPNs and dSPNs.
Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in...

Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in...

Instrumental actions rely on flexible, goal-directed behavior, but can become more rigid and habit-like with repetition. This study shows that decreased adaptive signaling capacity of striatal...

journals.plos.org
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Marie-Charlotte retweeted
Brian Sweis (@BrianMSweis) profile picture
Brian Sweis@BrianMSweis15 Jul 2025
New paper!🚨📝 Paper: tinyurl.com/2cycsy6d Press release: tinyurl.com/yur3j2n8 How the 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however🧵👇1/6
Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex...

Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex...

Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.

science.org
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After vicarious social defeat, VTA DA neuron activity & involvement of a VTA–ACC circuit were linked to social avoidance & anxiety in ♂️🐭, with VTA neuroinflammatory signaling implicated as a molecular driver of behavioral differences nature.com/articles/s41386-0…

VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social...

Neuropsychopharmacology - VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice

nature.com
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Marie-Charlotte retweeted
Becca Cole (@Beccaaa_57) profile picture
Becca Cole@Beccaaa_5720 May 2025
Our paper on opioid receptor regulation of mPFC inhibitory microcircuits is out as an early release jneurosci.org/content/early/… @allichonmc @mejoffe ! More to come on these systems in opioid dependence 🧠
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Please see this new publication by Arthur Godino, Marine Salery, and others now online in @Nature. We show opposite roles for D1 vs D2 dopamine receptor- expressing neurons in ventral hippocampus in controlling approach-avoidance behavior. @SinaiBrain rdcu.be/ek2DS
Image from Eric J. Nestler, MD, PhD (@EricJNestler)
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Glad to say that I’ve started my postdoc at @PittPsychiatry with the Joffe lab @mejoffe. Let the adventure begin 🧠
Image from Marie-Charlotte (@allichonmc)
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It’s finally out! I'm excited to share the last piece of my work from @LabPapaleo. If you’re interested in emotion-related behaviors in mice, check it out! A huge thanks to all the co-authors and our collaborator @FelixFelxfel for making this possible! nature.com/articles/s41593-0…
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Marie-Charlotte retweeted
Niko Massaly (@MassalyNiko) profile picture
Niko Massaly@MassalyNiko23 Oct 2024
Out today ! Work co-lead by Joanna Ciatti, Abraham Vazquez-Guardado and @VickiBrings in John Rodgers’s , @robgereau and @jomoronc lab Happy to have participated in developing this new device. Hope we can truly help people with this. Please share science.org/doi/10.1126/scia…
An autonomous implantable device for the prevention of death from opioid overdose

An autonomous implantable device for the prevention of death from opioid overdose

A lifesaving device automatically detects opioid overdose and rapidly responds with naloxone, averting overdose fatalities.

science.org
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1st PD paper with @Faurelab is officially published today ! 🎉 nature.com/articles/s41467-0…
Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an...

Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an...

Nature Communications - How nicotine impacts the adolescent development of neural circuitry is not fully understood. Here authors show that early adolescent nicotine exposure in male mice blocked...

nature.com
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Check this out 🧠 New paper from the lab 🥳 Serotonin release in the habenula during emotional contagion promotes resilience | Science ⁦@_mameli_⁩ ⁦@DNF_neuro⁩ ⁦@Patricia_MolMol⁩ ⁦@MauroCongiu⁩ ⁦⁦@LeofMic⁩ science.org/doi/10.1126/scie…
Serotonin release in the habenula during emotional contagion promotes resilience

Serotonin release in the habenula during emotional contagion promotes resilience

Negative emotional contagion—witnessing others in distress—affects an individual’s emotional responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We...

science.org
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A highly informative article in the New York Times about the powerful interplay between chronic stress and general medical conditions. @ScottRussoPhD and his work in @SinaiBrain's Brain and Body Research Center are heavily cited. nytimes.com/2024/06/27/well/…
How Stress Can Mask the Symptoms of Chronic Disease (Published 2024)

How Stress Can Mask the Symptoms of Chronic Disease (Published 2024)

The signs of chronic illness are often dismissed by doctors as “just stress.” But that comes from a complex relationship between sickness and stress itself.

nytimes.com
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Marie-Charlotte retweeted
CLaE (@leafs_s) profile picture
CLaE
@leafs_s15 Aug 2024
Neuropsychopharmacology Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging nature.com/articles/s41386-0…
Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging

Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging

Neuropsychopharmacology - Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging

nature.com
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Marie-Charlotte retweeted
tina kim (@tinakim_neuro) profile picture
tina kim
@tinakim_neuro11 Sep 2023
Excited to share the first paper from our lab! tinyurl.com/5n7fvwvh We engineered a new kind of time-gated calcium integrator, CaST, that can rapidly and non-invasively tag activated neurons in vivo with a small, biochemical handle. What makes this tool special and unique? 1/6
Image from tina kim (@tinakim_neuro)
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