Anton Henssen (@anton_gh) header
Anton Henssen (@anton_gh) profile picture

Anton Henssen

@anton_gh

Head of preclinical pediatric cancer research @ChariteBerlin ECRC @MDC_Berlin. Extrachromosomal DNA (ecDNA) in cancer. Cancer Grand Challenges Team eDyNAmiC

 Berlin, Allemagne
Henssenlab.de
Joined December 2011
  • Tweets1.5K
  • Following1.5K
  • Followers1.1K
119Media
Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)Photo by Anton Henssen (@anton_gh)
Glad to see this work led by @_YiBei online @CD_AACR 🔥🔥! Thank you to all the co-authors (esp. Jan Dörr) and @imsmd for the great editorial guidance !!👇🏻👇🏻
Elizabeth McKenna (@ElizSMcKenna) profile pictureElizabeth McKenna@ElizSMcKenna11 Jan 2024
Now online in @CD_AACR: Passenger Gene Co-Amplifications Create Collateral Therapeutic Vulnerabilities in Cancer - by @_YiBei, @anton_gh, Jan Dörr, and colleagues doi.org/10.1158/2159-8290.CD… @DKTK_ @ChariteBerlin @MDC_Berlin @berlinnovation
Image from Elizabeth McKenna (@ElizSMcKenna)
7
9
5
49
17,572
Happy to share our new study published this week in @NatureGenet 🔥🔥🔥🔥 nature.com/articles/s41588-0…
Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

Nature Genetics - Single-micronucleus sequencing and live-cell imaging of cancer cells, as well as analyses of biopsies from patients with neuroblastoma, reveal that ecDNA in micronuclei limits...

nature.com
3
14
52
4,505
Challenge update: extrachromosomal DNA 🧬 New findings from team eDyNAmiC, published in #NatureGenetics (@NaturePortfolio), show that where ecDNA sits in the cell can limit its power. This could open new avenues for therapies to exploit this weakness, to slow tumour growth and improve outcomes for patients with some of the most aggressive cancers. The work was led by three early career researchers: Lotte Brückner, Robin Xu and Jun Tang, in the labs of @anton_gh (@MDC_Berlin), Paul Mischel and @HowardYChang (@StanfordMed). In our latest news article, Lotte talks about her career so far, coordinating more than 60 co-authors, and where she was when she heard the paper was accepted. 👉 Read the full story: bit.ly/3VIhKpe
4
7
563
Very happy to share our new Perspective in Nature Reviews Genetics, led and written primarily by my colleague Liam P. Shaw: “The shared evolutionary capacities of plasmids and extrachromosomal DNA” nature.com/articles/s41576-0…
The shared evolutionary capacities of plasmids and extrachromosomal DNA

The shared evolutionary capacities of plasmids and extrachromosomal DNA

Nature Reviews Genetics - Plasmids in bacteria and extrachromosomal DNA in cancer both generate copy-number variation, alter gene expression and promote rapid adaptation. In this Perspective, Shaw...

nature.com
4
7
1,284
📢 New 2027 conference announced! Building on the success of our inaugural conference in 2025, the second edition of the Cancer Grand Challenges Conference: Extrachromosomal DNA (ecDNA) will return from 22-24 June 2027 at @royalsociety in London. Stay tuned for speaker and programme announcements, and register your interest today ➡️ bit.ly/4wGXrFz
Image from Cancer Grand Challenges (@CancerGrand)
Image from Cancer Grand Challenges (@CancerGrand)
3
2
769
I have only tried it for one week so far , but I couldn’t agree more. So much better then X !!
New Scientist (@newscientist) profile pictureNew Scientist
@newscientist25 Nov 2024
Bluesky is the future of social media, says Chris Stokel-Walker, thanks to the ability to choose your own algorithm and control what you see. newscientist.com/article/245…
Bluesky is ushering in a pick-your-own algorithm era of social media | New Scientist

Bluesky is ushering in a pick-your-own algorithm era of social media | New Scientist

More than 20 million people have joined Bluesky, a social network that gives you fine-grained control over what you see and who you interact with. I think it is the future of social media, says Chris...

newscientist.com
1
5
396
Anton Henssen retweeted
Barbara Marte (@BarbMarte) profile picture
Barbara Marte@BarbMarte20 Nov 2024
new out inNature nature.com/articles/s41586-0…
Normal breast tissues harbour rare populations of aneuploid epithelial cells

Normal breast tissues harbour rare populations of aneuploid epithelial cells

Nature - Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that...

nature.com
23
3
126
15,984
I just created an account at blue sky my handle is @Anton-Henssen.blsky.social
9
643
Very excited to contribute to this conference on ecDNA ! Anyone interested in this topic should register 👇🏻👇🏻🔥🔥
Cancer Grand Challenges (@CancerGrand) profile pictureCancer Grand Challenges
@CancerGrand12 Nov 2024
Next June, join us at the #CancerGrandChallenges Conference: extrachromosomal DNA 📢 We're thrilled to announce the first edition in our new conference series, where we'll be convening researchers from around the globe to discuss ecDNA. Learn more 👉 bit.ly/4evoVod
Image from Cancer Grand Challenges (@CancerGrand)
2
16
1,263
We are very excited to open the registration for the upcoming @EMBOevents on Chromosome Segregation and Aneuploidy in beautiful Stresa!!! You can find all the relevant info at meetings.embo.org/event/25-a… Hope to see many of you in a few months!! 🧬🔬😍 #ChromoPloidy25
Chromosome Segregation and Aneuploidy

Chromosome Segregation and Aneuploidy

Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

meetings.embo.org
2
24
1
95
8,870
Three papers and the cover of @Nature on ecDNA !!! 🔥🔥 What an amazing achievement by our @CancerGrand team eDyNAmiC led by @mischellab @HowardYChang @CharlesSwanton @MariamJHanjani @cbailey_58 @kinglhung and many more !!! 👏🏻👏🏻👏🏻👏🏻🍾🍾🍾🍾 Much more to come soon.
Cancer Grand Challenges (@CancerGrand) profile pictureCancer Grand Challenges
@CancerGrand6 Nov 2024
Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00
Image from Cancer Grand Challenges (@CancerGrand)
4
24
67
8,719
Happy that our team @BrucknerLotte @RoChamorro1 contributed to this paper @Nature : nature.com/articles/s41586-0…
Coordinated inheritance of extrachromosomal DNAs in cancer cells

Coordinated inheritance of extrachromosomal DNAs in cancer cells

Nature - Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.

nature.com
2
7
301
What a beauty , look at these ecDNA on the cover !!
Image from Anton Henssen (@anton_gh)
7
234
Congrats @m_i_spiral @StefanMundlos @MundlosLab ! 👏🏻👏🏻
Vassilis Roukos (@RoukosVassilis) profile pictureVassilis Roukos@RoukosVassilis31 Oct 2024
Happy to share our new work in collaboration with the @MundlosLab @StefanMundlos & @AkisPapantonis labs, published today in @MolecularCell Many congratulations to all co-authors and many thanks to the funding agencies for the important support @imbmainz @sfb1361 @upatras
1
6
501
Call for Abstracts | 2025 Steel Symposium in Developmental Oncology @MSKCancerCenter in New York City next May! view.cme.mskcc.org/?qs=23cb4… #MSKDevOnc #MSKkids
3
10
1,086
1/4 Our @biorxivpreprint, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells can uniquely tolerate EWSR1::FLI1 expression, leading to tumor formation in vivo. A big thanks to our collaborators @clairearataphd and @CrumpLab for this adventurous journey! #NeuralCrest #cancer #EwingSarcoma #zebrafish @amatrudalab @ChildrensLA @biorxiv_cancer👉biorxiv.org/content/10.1101/…
9
36
5
122
24,927
🔥🔥👇🏻👇🏻
WeiniHuang (@huang_weini) profile pictureWeiniHuang@huang_weini27 Oct 2024
Our new preprint led by @eliscanu96 on modeling multiple genotypes/phenotypes of extra-chromosomal DNA is online. Glad that Elisa will continue to work on the application of her theoretical work on experimental and biological context. stay tuned! biorxiv.org/content/10.1101/…
1
6
750
Anton Henssen retweeted
Anirban Maitra (@Aiims1742) profile picture
Anirban Maitra@Aiims174226 Oct 2024
Fantastic talk by @VineetBafna3 @UCSDHealth on focal amplifications in cancer, mostly driven by extrachromosomal DNA or ecDNA (heard a lot about ecDNAs at this @ChampalimaudF meeting) but also by breakage-fusion-bridges (BFBs). Some important focal amplification resources from the Bafna Lab: AmpliconSuite AmpliconRepository github.com/AmpliconSuite ampliconrepository.org/ Historical allusion to 1939 @PNASNews paper by Barbara McClintock on BFBs. Team ecDyNAmiC @CancerGrand
Image from Anirban Maitra (@Aiims1742)
1
6
25
3,827
Wow , this is really cool !!!
Nicolas Altemose (@NAltemose) profile pictureNicolas Altemose@NAltemose25 Oct 2024
I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin @matt_franklin_ (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.1101/…
Human Satellite 3 DNA encodes megabase-scale transcription factor binding platforms

Human Satellite 3 DNA encodes megabase-scale transcription factor binding platforms

Eukaryotic genomes are frequently littered with large arrays of tandem repeats, called satellite DNA, which underlie the constitutive heterochromatin often found around centromeric regions. While...

biorxiv.org
1
357
Fantastic work on ecDNA spatio-temporal evolution 🔥🔥👇🏻👇🏻
Imran Noorani (@drimrannoorani) profile pictureImran Noorani@drimrannoorani26 Oct 2024
Very pleased to share our new online pre-print! We explore the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in human glioblastoma. biorxiv.org/content/10.1101/…. A 🧵
Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma

Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma

Oncogene amplification on extrachromosomal DNA (ecDNA) is strongly associated with treatment resistance and shorter survival for patients with cancer, including patients with glioblastoma. The...

biorxiv.org
1
7
701
Anton Henssen retweeted
Matt Jones (@MattG_Jones) profile picture
Matt Jones@MattG_Jones25 Oct 2024
I'm thrilled to share our new study of the spatial evolution of Kras;p53-driven mouse lung adenocarcinoma! It's been fantastic leading this with @dianyang1117 & @sundakao, and enjoying a long-standing collaboration with @JswLab @YosefLab & @insitubiology. biorxiv.org/cgi/content/shor…
8
38
4
133
23,222
Load more