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Bertoglio lab (FMC/UFSC)

@bertogliolab

Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our lab and others!

 Florianopolis, SC, Brazil
Joined October 2010
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🆕Excited to share our latest review on psychedelics and fear extinction @Isabeus_ @FarmacoUFSC @fapesc @UFSC journals.sagepub.com/doi/10.…
Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative...

Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative...

Background: Individuals with anxiety and stress-related disorders frequently demonstrate impaired threat extinction. Although psilocybin, lysergic acid diethyla...

journals.sagepub.com
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Projections from medial prefrontal cortex and hippocampus to midline thalamus and perirhinal cortex: a double retrograde tracing study in rats link.springer.com/article/10…
Projections from medial prefrontal cortex and hippocampus to midline thalamus and perirhinal...

Projections from medial prefrontal cortex and hippocampus to midline thalamus and perirhinal...

Brain Structure and Function - The nucleus reuniens (RE), paraventricular nucleus of the thalamus (PVT), and perirhinal cortex (PRC), which have reciprocal connections with both the medial...

link.springer.com
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A case study in conflicts of interest science.org/doi/10.1126/scie…
A case study in conflicts of interest

A case study in conflicts of interest

In 2014, a paper—Nutt, et al—was published in the journal European Addiction Research that purported to evaluate the relative harms of 12 nicotine-containing products, based on a review by an expert...

science.org
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Stimulated protein degradation to promote mitochondrial function and neuronal survival science.org/doi/10.1126/scie…
Stimulated protein degradation to promote mitochondrial function and neuronal survival

Stimulated protein degradation to promote mitochondrial function and neuronal survival

Targeted protein degradation is a promising modality to treat cancer or inflammation, but whether it can provide a similar benefit for disorders caused by pervasive protein dysregulation is unclear....

science.org
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Taking the brakes off a stress response science.org/doi/10.1126/scie…
Taking the brakes off a stress response

Taking the brakes off a stress response

A small molecule improves the fitness of cells containing diseased mitochondria

science.org
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Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor-Expressing Neurons in the Medial Prefrontal Cortex doi.org/10.1002/advs.78527
Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the...

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the...

This study shows that propofol modulates fear-memory reconsolidation in mice. It works by suppressing D2 receptor-expressing neurons within the medial prefrontal cortex and their connections to the...

advanced.onlinelibrary.wiley.com
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Ligand-specific effects of 5-HT2A receptor antagonists on fear extinction in C57BL/6J mice: Comparative insights from MDL 11,939 and MDL 100,907 sciencedirect.com/science/ar…
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Image from Mestrado Profissional Farmacologia UFSC (@mest_prof_fmc)
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Perinatal elimination of genetically aberrant human cortical neurons nature.com/articles/s41586-0…
Perinatal elimination of genetically aberrant human cortical neurons

Perinatal elimination of genetically aberrant human cortical neurons

Nature - Single-neuron sequencing shows that widespread genomic abnormalities are common prenatally but largely eliminated around birth, indicating developmental genome quality control in human...

nature.com
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Alzheimer’s disease genetics converges on microglial and neuronal dysregulation nature.com/articles/s41586-0…
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation

Alzheimer’s disease genetics converges on microglial and neuronal dysregulation

Nature - A multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-variant contribution...

nature.com
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Emotion regulation capacity lacks a shared neural signature nature.com/articles/s41586-0…
Emotion regulation capacity lacks a shared neural signature

Emotion regulation capacity lacks a shared neural signature

Nature - Sensorimotor and amygdala activation, but not canonical prefrontal control circuits, indicate emotion regulation capacity.

nature.com
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How personalization and psychedelics are revitalizing psychiatry nature.com/articles/d41586-0…
How personalization and psychedelics are revitalizing psychiatry

How personalization and psychedelics are revitalizing psychiatry

Nature - Fresh ideas are welcome in a discipline in which progress is rare — provided they are applied rigorously.

nature.com
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Bertoglio lab (FMC/UFSC) retweeted
Prof. Cleiton Lopes Aguiar (@NeuroCleiton) profile picture
Prof. Cleiton Lopes Aguiar@NeuroCleitonOct 28
Image from Prof. Cleiton Lopes Aguiar (@NeuroCleiton)
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Bertoglio lab (FMC/UFSC) retweeted
Felipe Neto 🦉 (@felipeneto) profile picture
Felipe Neto 🦉
@felipenetoOct 27
If you're from the US: Don't believe Flávio Bolsonaro is fleeing persecution from a leftist dictatorship. He's deeply involved in serious corruption cases with very strong evidence. He's fleeing to your country because he's a corrupt coward who knows he'll be convicted.
Image from Felipe Neto 🦉 (@felipeneto)
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Psychedelic Hormesis: LSD Activates Adaptive Stress Transcriptional Programs in the Prefrontal Cortex biorxiv.org/content/10.64898…
Psychedelic Hormesis: LSD Activates Adaptive Stress Transcriptional Programs in the Prefrontal...

Psychedelic Hormesis: LSD Activates Adaptive Stress Transcriptional Programs in the Prefrontal...

Background Classic psychedelics are serotonergic agents increasingly recognized for their ability to produce rapid and long-lasting therapeutic effects in several neuropsychiatric conditions, yet the...

biorxiv.org
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Controlling the uncontrollable? navigating naturalistic and controlled dosing in cannabis research link.springer.com/article/10…
Controlling the uncontrollable? navigating naturalistic and controlled dosing in cannabis research

Controlling the uncontrollable? navigating naturalistic and controlled dosing in cannabis research

Psychopharmacology - Cannabis research is advancing rapidly, yet fundamental questions persist regarding the optimal design of human studies to empirically assess the potential harms and benefits...

link.springer.com
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Vagus nerve stimulation enhances context discrimination and dentate gyrus neurogenesis through Trk signaling doi.org/10.1093/braincomms/f…
Vagus nerve stimulation enhances context discrimination and dentate gyrus neurogenesis through Trk...

Vagus nerve stimulation enhances context discrimination and dentate gyrus neurogenesis through Trk...

Raza et al. discovered that vagus nerve stimulation in the home cage increased markers of neurogenesis in adult rats. Vagus nerve stimulation during fear c

academic.oup.com
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Glucocorticoid dynamics predict susceptibility and resilience to traumatic stress in male and female rats doi.org/10.3389/fncel.2026.1…
Frontiers | Glucocorticoid dynamics predict susceptibility and resilience to traumatic stress in...

Frontiers | Glucocorticoid dynamics predict susceptibility and resilience to traumatic stress in...

IntroductionThe mammalian stress response relies on tightly regulated HPA axis signaling, and disruptions in glucocorticoid feedback are implicated in stress...

frontiersin.org
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mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells pnas.org/doi/abs/10.1073/pna…
mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduc...

mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduc...

G protein–coupled receptors (GPCRs) are pivotal sensors of the mechanical environment, yet how they sense and transduce physical stimuli into bioch...

pnas.org
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Psychedelics and psychosis: A systematic review of recent-era studies (1984-2025) doi.org/10.1177/026988112614…
Psychedelics and psychosis: A systematic review of recent-era studies (1984–2025) - José Augusto...

Psychedelics and psychosis: A systematic review of recent-era studies (1984–2025) - José Augusto...

Purpose: This systematic review evaluates the relationship between classical psychedelic drugs (D-Lysergic acid N,N-diethylamide, psilocybin, ayahuasca/N-N-dime...

journals.sagepub.com
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The intermediate hippocampus integrates shock-observation and spatial information during observational fear memory in male rats nature.com/articles/s41467-0…
The intermediate hippocampus integrates shock-observation and spatial information during observat...

The intermediate hippocampus integrates shock-observation and spatial information during observat...

Nature Communications - The authors find that in rats, responses to witnessing others’ distress scale with hippocampal place-field firing, linking observed danger to the observer’s...

nature.com
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