Ben Sabari (@bsabari) profile picture

Ben Sabari

@bsabari

Associate Professor at UTSW studying nuclear organization by transcriptional condensates

 Dallas, TX
sabarilab.com
Joined July 2009
  • Tweets1.4K
  • Following933
  • Followers3K
23Media
Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)Photo by Ben Sabari (@bsabari)
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. cell.com/cell/fulltext/S0092….
Image from Ben Sabari (@bsabari)
11
39
2
202
19,745
Ben Sabari retweeted
Will Chen (@wchenomics) profile picture
Will Chen@wchenomicsOct 21
Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!
10
81
6
398
23,287
Ben Sabari retweeted
Liling Wan (@LilingWanLab) profile picture
Liling Wan@LilingWanLabOct 21
That’s a wrap on our @ForbeckForums on Nuclear Condensates in Cancer! Amazing group, fantastic science, and thought-provoking discussions in beautiful Pacific Grove! A great pleasure co-organizing this with @bsabari. Many thanks to @ForbeckForums for making this possible!
Image from Liling Wan (@LilingWanLab)
Image from Liling Wan (@LilingWanLab)
Image from Liling Wan (@LilingWanLab)
Image from Liling Wan (@LilingWanLab)
5
20
1,515
Ben Sabari retweeted
Evgeny Kvon (@evgenykvon) profile picture
Evgeny Kvon@evgenykvonOct 14
Are weak TF motifs important? @ZeitlingerLab use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong motifs to open chromatin. Preview w/ @gracecbower: cell.com/cell-genomics/fullt… Paper: cell.com/cell-genomics/fullt…
Deep learning uncovers hidden power of low-affinity motifs

Deep learning uncovers hidden power of low-affinity motifs

Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequen...

cell.com
2
28
159
6,810
i'm happy to share that our lab has joined @FoxChaseCancer! v proud of what our team achieved in Madison & now we look forward to this next chapter in the vibrant Philly scientific ecosystem - actively recruiting at all levels across the biological sciences and engineering!
20
6
1
83
17,961
Apply and come to Chicago and NITMB where there many fun scientists to talk and brainstorm with at @NorthwesternU and @UChicago !
NSF-Simons NITMB (@NITMB_Chicago) profile pictureNSF-Simons NITMB@NITMB_ChicagoSep 22
Are you an early-career researcher looking to develop mathematical, theoretical, and computational approaches to study any area of biology? We’re looking for researchers to join the NITMB Fellows program! Apply by November 15, 2026 nitmb.org/nitmb-fellows-prog…
Image from NSF-Simons NITMB (@NITMB_Chicago)
1
12
1,737
After a highly productive postdoc career in my lab, @YoseopYoon is starting his own lab @UTArlington, studying phase separation in RNA processing. Contact him if you’re interested in joining his lab!
Image from Yongsheng Shi (@YongshengShi)
5
15
201
16,365
Ben Sabari retweeted
Bede Portz (@YSPTSPS) profile picture
Bede Portz@YSPTSPSAug 25
idp.nature.com/authorize?res…
Variant characterization in the intrinsically disordered human proteome

Variant characterization in the intrinsically disordered human proteome

Nature Structural & Molecular Biology - Proteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in...

nature.com
1
6
28
3,536
Proud to see our work featured! Grateful to my thoughtful and hardworking team, and to our wonderful collaborators who make this work possible. Stay tuned, we’re excited to share some of what we’ve been working on as preprints later this year! 🤠🔬🧠
UTSW Science (@UTSWScience) profile pictureUTSW Science@UTSWScienceAug 19
Exploring the brain one neuron at a time, the @ShahmoraLab uses nanoscale imaging to uncover how neurodegenerative diseases like Parkinson’s and ALS begin and progress. Learn about the Shahmoradian Lab and its groundbreaking research: bit.ly/4wsg3Ju #UTSWMeetTheMinds
1
8
53
13,703
Online Now: Acidic transcription factors position the genome at nuclear speckles through transcription -dependent and -independent mechanisms dlvr.it/TV459S
Image from Molecular Cell (@MolecularCell)
30
1
101
7,152
Ben Sabari retweeted
Bray Lab (@BrayLabCam) profile picture
Bray Lab@BrayLabCamAug 13
A bit belatedly sharing this beautiful work of carmina’s. A real tour de force of live imaging! Direct observation of Notch signaling–induced transcription hubs mediating gene-expression responses | Science Advances science.org/doi/10.1126/scia…
Direct observation of Notch signaling–induced transcription hubs mediating gene-expression responses

Direct observation of Notch signaling–induced transcription hubs mediating gene-expression responses

Multicolor live imaging reveals Notch transcription-complex enrichment at a gene locus, which precedes and informs transcription.

science.org
7
25
1,841
Jim Shorter and his postdoc Miriam wrote a beautiful preview of our most recent paper on mRNA preventing misfolding of IDR-containing proteins. UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell cell.com/cell/fulltext/S0092…
3
14
47
3,363
RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription dlvr.it/TTbgQr
Image from Molecular Cell (@MolecularCell)
18
94
10,269
Ben Sabari retweeted
Huaiying Zhang (@lab_zhang) profile picture
Huaiying Zhang@lab_zhangJul 17
Like every time, I had fun reading this foundational phase separation paper from the Rosen lab
Nature Reviews Molecular Cell Biology (@NatRevMCB) profile pictureNature Reviews Molecular Cell Biology@NatRevMCBJul 13
New Online! A demonstration that multivalent interactions drive condensate formation dlvr.it/TTW5Cg
Image from Nature Reviews Molecular Cell Biology (@NatRevMCB)
6
21
4,162
Congratulations to former grad student @Heankel_ on being selected as a 2026 Jane Coffin Childs Fellow! jccfund.org/blog/the-jane-co…
The Jane Coffin Childs Fund for Medical Research Names its 2026 Fellows - Jane Coffin Childs...

The Jane Coffin Childs Fund for Medical Research Names its 2026 Fellows - Jane Coffin Childs...

The Jane Coffin Childs Memorial Fund for Medical Research (Jane Coffin Childs Fund/JCC Fund) is an unwavering supporter of biomedical research, having funded early-career researchers for nearly...

jccfund.org
1
2
19
2,106
"Find Your Way" - Olson strikes inspiring chords in musical keynote at Graduate School commencement - Center Times Plus, UT Southwestern utsouthwestern.edu/ctplus/st… via @@utswnews
Olson strikes inspiring chords in musical keynote at Graduate School commencement - Center Times...

Olson strikes inspiring chords in musical keynote at Graduate School commencement - Center Times...

Hear Eric Olson, Ph.D., sing his original song at the commencement ceremony for the UTSW Graduate School of Biomedical Sciences.

utsouthwestern.edu
1
6
36
2,336
Ben Sabari retweeted
Liling Wan (@LilingWanLab) profile picture
Liling Wan@LilingWanLabJun 12
Excited to share that our preprint 'RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription' is now online @MolecularCell cell.com/molecular-cell/full… @PennMedCSO @PennCancer @PennEpiInst
Image from Liling Wan (@LilingWanLab)
Liling Wan (@LilingWanLab) profile pictureLiling Wan@LilingWanLab4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

Aberrant chromatin-associated condensates have emerged as drivers of transcriptional dysregulation in cancer, yet the mechanisms regulating their formation and function remain poorly understood....

biorxiv.org
6
16
85
13,098
Ben Sabari retweeted
Bede Portz (@YSPTSPS) profile picture
Bede Portz@YSPTSPSJun 14
cell.com/cell-reports/fullte…
Kinase condensates enrich ATP and trigger autophosphorylation

Kinase condensates enrich ATP and trigger autophosphorylation

Lea et al. find that some kinases form highly concentrated condensates that enrich ATP through electrostatic potential and significantly increase rates of trans-autophosphorylation. Condensates that...

cell.com
6
23
2,897
Excited to share the first pre-print from our lab!! Check it out here! biorxiv.org/content/10.64898… We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Image from Jonathan Henninger (@jehenninger)
4
84
338
21,072
Intrinsically disordered proteins (IDPs) flit between diverse shapes and interact in fuzzy ensembles whose collective properties shape function. Q: Can we rationally design emergent properties of IDPs? Our newest preprint takes a stab at this 🧵 biorxiv.org/content/10.64898…
Image from Krishna Shrinivas (@shrinivaslab)
3
18
88
7,151
Thrilled to see our Deep-Phase paper now online in @CellCellPress!🎉 The final version expands Deep-Phase across labeling modalities, adds dual-condensate imaging to dissect pathway specificity, and shows greater robustness to batch effects than classical image-analysis methods.
Cell (@CellCellPress) profile pictureCell@CellCellPressJun 4
Now online! Deep learning of functional perturbations from condensate morphology dlvr.it/TStHTc
Deep learning of functional perturbations from condensate morphology

Deep learning of functional perturbations from condensate morphology

A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral condensate morphology to reveal underlying biochemical states. Applying this framework reveals a previously...

cell.com
1
8
20
2,289
Load more