The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Cambridge, MA
Joined November 2014
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Cell Host & Microbe retweeted
✨#SUSTech researchers publish new findings in @cellhostmicrobe, dissecting the complete immune pathway of the bacterial DRT2 antiphage defence system. This work expands our understanding of nucleic acid function and genetic information flow. 🧬
Read more: newshub.sustech.edu.cn/en/?p…
Cell Host & Microbe retweeted
From gut microbiota to cancer immunotherapy.
New research highlights how Akkermansia muciniphila may help overcome resistance to anti-PD-1 therapy in colorectal cancer.
An encouraging direction for microbiome-based approaches, with clinical evidence still at an early stage.
Akkermansia enhances anti-PD-1 efficacy
A. muciniphila attenuates macrophage efferocytosis to overcome PD-1 resistance in microsatellite-stable colorectal cancer (MSS CRC). Phase 1 trial supports microbiome modulation to improve immunotherapy in MSS CRC
cell.com/cell-host-microbe/f…
Cell Host & Microbe retweeted
"Akkermansia muciniphila protects against endometritis through a tyrosol-mediated gut–uterus axis."
Learn more in Cell Host & Microbe: cell.com/cell-host-microbe/f…
Jiuxi Liu, Xufeng Xie, and Yongguo Cao
@cellhostmicrobe
ALT grpahical abstract
Cell Host & Microbe retweeted
Dietary pectin drives B. uniformis remodeling to enrich surface glycosphingolipid HexCer, while neutrophils sense the signal to promote IgA production, helping the bacterium colonize the gut & protects against colitis
Read more via @cellhostmicrobe :
tinyurl.com/4b9c2tr6
Cell Host & Microbe retweeted
Could a sugar molecule produced by a gut bacterium offer a viable alternative to GLP-1s? A new paper in @cellhostmicrobe sheds light on a previously unknown link between the gut microbiome and metabolism.
Neeraj Surana, MD, PhD, and colleagues identified a previously unknown connection between the gut microbiome and metabolism.
Their findings suggest a naturally occurring gut bacterium may help regulate energy expenditure and visceral fat.
medschool.duke.edu/news/swee…
Cell Host & Microbe retweeted
A commensal-derived sugar protects against obesity by regulating immunometabolism.
Learn more in Cell Host & Microbe: cell.com/cell-host-microbe/f…
Neeraj K. Surana & colleagues
@cellhostmicrobe
ALT graphical abstract
Cell Host & Microbe retweeted
A spit test detects colorectal cancer with more accuracy than the standard stool samples, opening path to develop less-invasive screening for gastrointestinal cancers.
More in Cell Host & Microbe: cell.com/cell-host-microbe/f…
Jihyun F. Kim & colleagues
@cellhostmicrobe
ALT graphical abstract
Cell Host & Microbe retweeted
Scientist with co-authors Gala Ramón-Zamorano and Sheila Mainye present a systematic proteomic characterization of the chromatin domains in Plasmodium falciparum, an ancient human pathogen with a unique genome composition and epigenetic blueprint. 🦠 bit.ly/4cBe5Py
Only in @cellhostmicrobe! 📣
Cell Host & Microbe retweeted
Epigenetics Update - Protein landscape of the chromatin domains in the malaria parasite Plasmodium falciparum u.epigenome.us/DExxlqg6
Tobias Spielmann and Richárd Bártfai in @cellhostmicrobe
#Epigenetics #Chromatin #Malaria
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Gain hi-res insight; epigenometech.com
Cell Host & Microbe retweeted
From hosts to habitats: explore the new @cellhostmicrobe Focus issue on Environmental microbiology.
Discover research spanning soil microbiomes, reef restoration, deep-ocean microbes & more.
Explore the issue: hubs.li/Q04tkPp40
Cell Host & Microbe retweeted
Upon Mycobacterium tuberculosis infection, strong, sustained type I IFN signaling cell intrinsically suppresses IFNγ responsiveness, thus rendering macrophages permissive to bacterial growth @cellhostmicrobe @UCBerkeley
cell.com/cell-host-microbe/f…
Cell Host & Microbe retweeted
Our work is now online @cellhostmicrobe
#OAHuge congrats to all authors @HimanshuChhill3 @leonardojo @RedkarAmey Volkan @kaisakajala @jonathandgjones supported primarily by the @ERC_Research #StG
=> cell.com/cell-host-microbe/f…
@LeidenBiology @UniLeiden
Cell Host & Microbe retweeted
Bacterial supplements may make conception easier (whether natural or in vitro) among women over 35.
Learn more in Cell Host & Microbe: cell.com/cell-host-microbe/f…
Heng Pan (潘恒), Yang Yu(于洋), Ping Zhou(周平), Rong Li (李蓉) & colleagues
@cellhostmicrobe
ALT first page of Cell Host & Microbe paper: \"Lactobacillus gasseri postbiotics ameliorate age-related decline in endometrial receptivity\"\n
Cell Host & Microbe retweeted
Are we ready to improve vaccines' efficacy through microbiome therapies?
This Forum examines why empiric probiotics and broad taxonomic approaches are largely ineffective in boosting mucosal vaccine immunity and proposes alternatives
@cellhostmicrobe
tinyurl.com/yyrbvjd7
Cell Host & Microbe retweeted
Gut microbiota alters drug metabolism and therapeutic outcomes
This review in @cellhostmicrobe updates progress in microbiota-modulated drug metabolism and assesses microbe-targeted approaches to enhance clinical drug performance:
tinyurl.com/5f5pua4u
Cell Host & Microbe retweeted
Is it time for engineering commensal microbes for host health?
This timely review updates advances in the context of inflammatory diseases, metabolic disorders, cancer, and infectious diseases
@cellhostmicrobe
tinyurl.com/c2vz6chh
Cell Host & Microbe retweeted
The latest special issue of @CellHostMicrobe explores breakthroughs in engineered microbes, phage therapy, AI-driven antimicrobial discovery, precision medicine, and more, highlighting the next generation of microbial therapeutics.
Read more: hubs.li/Q04pzDr00
Cell Host & Microbe retweeted
Meta-analysis reveals microbiome signatures for colorectal cancer that are universal across age groups and sequencing methods
Fusobacterium subspecies showed biogeographic variation in colorectal cancer enrichment
@cellhostmicrobe
tinyurl.com/5xezu5pa
Cell Host & Microbe retweeted
Antibiotics changed medicine because we learned how to mine nature.
Our next challenge is to mine the code of life itself.
Glad to share our latest piece with Anna Crysler, now out in @cellhostmicrobe @CellPressNews: “Mining the code of life for new antibiotics.”
We discuss how antibiotic discovery is moving from classical “dirt mining” and phenotypic screening toward digital platforms powered by genomics, metagenomics, deep learning, and generative AI.
The goal is not AI instead of experiments. It is to build tighter loops between computation and biology — systems that can search larger spaces, reduce rediscovery, and help design candidates with potency, safety, stability, spectrum, and resistance risk in mind.
A step toward our broader mission: using machines to understand and engineer biology.
Link: sciencedirect.com/science/ar…
