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6) These SCFAs, w/ butyrate appearing to have the greatest potential role in immunity due to its palliative effect in inflammatory bowel diseases. In part this appears due to the improved quality of the epithelial barrier & diminished bacterial translocation and immune activation
Modulating Th17-driven inflammation in ulcerative colitis with Chinese medicine: pathways, cytokines and beyond
link.springer.com/article/10…
Inulin‐Butyrate Nanogel for Modulation of Gut Microbiome, Intestinal Barrier, and Regulatory T‐Cells in Colitis - Park - 2026 - Small - Wiley Online Library onlinelibrary.wiley.com/doi/…
Protein puts brakes on intestinal inflammation, UTSW study finds: Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/…
My ER regulars spat at me. And opened my mind – psyche.co/turning-points/my-…
The Colitist retweeted
Two routes to breaking the therapeutic ceiling in IBD, on one timeline.
New drugs, if the trials succeed: the first anti-TL1As and obefazimod could reach Europe in 2028, and the first oral IL-23R peptide in 2029.
Combinations: all three phase 3 readouts land in 2027 and 2028. The first two-in-one injection could follow around 2031.
Next on Atomic IBD: the tablets, and whether they’ll arrive as partners rather than on their own.
Scientists finally discover how a common gut bacterium can trigger colon cancer sciencedaily.com/releases/20…
The Colitist retweeted
Pearls of management and approach to the refractory IBD. Dr. Rubin @IBDMD #IBDSUMMIT
The Colitist retweeted
EGIDs and IBD can share similar symptoms, making diagnosis challenging.
Join Michael K. Pickens, DO, FAAP, on Nov. 11 at 12 PM ET to explore their similarities, differences, and diagnostic approaches.
Register: apfed.org/webinars
#EGID #EosAware
Ulcerative colitis burden across 7MM to exceed 2.36 million cases by 2035, forecasts GlobalData
news-medical.net/news/202610…
The Colitist retweeted
Researchers at @WeillCornell @WCM_IBD found that patients with mild-to-moderate inflammatory bowel disease had a healthier gut microbiome after taking fluconazole, an antifungal medication. Treatment caused positive changes in both bacterial and fungal populations and was also associated with improved IBD symptoms.
The findings now need to be confirmed in a larger, placebo-controlled trial but they offer a potential framework for developing more precise, mycobiome-guided treatments for IBD in the future.
Learn more: news.weill.cornell.edu/news/…
The Colitist retweeted
Study suggests gut microbiome determines vaccine reaction
High levels of intestinal inflammation are linked to post-vaccination fever.
Read more: bit.ly/4zQTcsO
ALT gut microbiome
The Colitist retweeted
New podcast episode! Psychologist Margo Szabo, PhD, joins APFED’s Real Talk podcast to discuss coping with uncertainty and finding emotional support.
Listen: apfed.org/podcast
#EosAware #RealTalk
Common drugs may help dangerous viruses spread through the body sciencedaily.com/releases/20…
Scientists solve a 30-year mystery behind inflammatory bowel disease sciencedaily.com/releases/20…
Upadacitinib Stands Out in Real-World Ulcerative Colitis Care medscape.com/viewarticle/upa…
The Colitist retweeted
A study linked food allergy, asthma, eczema & rhinitis to a common origin in infancy—an unbalanced gut microbiome. Researchers pinpointed bacterial signatures that signalled microbiome imbalances in kids who would develop allergic disease by age 5. Read: allergicliving.com/2023/09/0…
The Colitist retweeted
Free Access: Exploring the Link Between Environmental Exposures and Disease via Direct Challenge. Anna M. Erickson, Ian A. Myles, Jodi L. Blake, Cezmi A. Akdis, Hirsh D. Komarow
Read the article here: doi.org/10.1111/all.70537
Mounting scientific evidence points to a link between environmental exposures and allergic diseases, as explained by the #epithelialbarriertheory. The clinical study THREAT, an acronym for Testing Harms Related to Exposure to Allergenic Toxins, compares the health impact of typical real-world indoor exposures to that of a controlled, healthier setting, such as free of toxic substances, reduced consumption of processed foods and purified air. Patient data will be collected on skin impedance, microbiome, cytokine profiles, and pulmonary function, among others.
#Allergy_journal
Read other articles published in #Allergy on the #epithelialbarrier here: journalallergy.com/barrier-a…
<fc>IL</fc>‐10‐secreting engineered macrophages alleviate <fc>DSS</fc>‐induced colitis with macrophage phenotypic modulation and gut microbiota remodeling in mice - Liu - Bioengineering & Translational Medicine - Wiley Online Library aiche.onlinelibrary.wiley.co…
Your blood could reveal inflammatory bowel disease 10 years before diagnosis sciencedaily.com/releases/20…
