@deepgenomics

Transforming #genomics with #deeplearning

 Toronto, ON
deepgenomics.com
Joined September 2014
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We're at the #OTS23 Meeting this week -- excited to share updates on our application of #AI to the discovery and development of #oligonucleotide and #RNA therapeutics. Stop by to learn more at the following 4 posters. oligotherapeutics.org/2023-a…
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3/4: P041:  BigRNA: A Large Neural Network Enabling Accurate Oligonucleotide Design and Variant Effect Predictions
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4/4: P104:  DeepMirBind: A Deep Learning Approach for MicroRNA Target Site Prediction and Design of Upregulation Oligonucleotides
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Découvrez ce nouveau travail étonnant du sponsor bronze de Vecteur @deepgenomics et du cofondateur de Vecteur, Brendan Frey. Comme indiqué ci-dessous, l'équipe a développé le premier modèle de base pour les thérapies ARN 👇
Deep Genomics@deepgenomics27 Sep 2023
We are thrilled to share our manuscript ‘An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics’ as a preprint! 🧵 biorxiv.org/content/10.1101/…

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics....

biorxiv.org
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Check out this amazing new work from Vector Bronze Sponsor @deepgenomics & Vector co-founder Brendan Frey. As outlined below the team developed the first foundation model for RNA therapeutics 👇
Deep Genomics@deepgenomics27 Sep 2023
We are thrilled to share our manuscript ‘An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics’ as a preprint! 🧵 biorxiv.org/content/10.1101/…

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics....

biorxiv.org
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Deep Genomics retweeted
Eric Topol
@EricTopol27 Sep 2023
The first foundation #AI model for RNA biorxiv.org/content/10.1101/… Predicting protein and microRNA binding sites, tissue-specific expression, variants -> gene expression and splicing ++ @deepgenomics @frey_brendan and colleagues
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We are thrilled to share our manuscript ‘An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics’ as a preprint! 🧵 biorxiv.org/content/10.1101/…

An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics

Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics....

biorxiv.org
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15/16 Here it’s important to have accurate predictions to lower the number of drugs screened. We analyzed variants in ClinVar that are amenable to this approach.
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16/16 We hope that our model BigRNA, and more RNA foundation models like it, will continue to transform the fields of disease variant interpretation and personalized therapeutics
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