MD • Cardiologist • Interventional Cardiology fellow • Italy 🇮🇹
Roma, Lazio
Joined January 2013
- Tweets441
- Following672
- Followers967
- Likes2.2K
Pinned Tweet
Another great experience this year at EuroPCR 2025! @PCRonline
I had the privilege to present our latest findings:
• Physiology-guided DCB-PCI 🎯 – a promising and minimalist approach, balancing safety, efficacy, and vessel preservation, with clinical outcomes comparable to standard physiology-guided DES-PCI.
• Contrast-induced IMR 💡 – a simpler, valid surrogate for thermodilution-based IMR, with strong potential for broader clinical application.
A great moment to reconnect with friends and colleagues 🤝 and learn from leading experts in the field!
A special thanks to my mentor for the continuous guidance and support – @AntonioMariaLe2
#EuroPCR2025 #InterventionalCardiology #DCB #FFR #IMR #Microcirculation #FullPhysiology
Domenico Galante retweeted
@crfheart @TCTConference
REMEDY-PILOT placebo -controlled (including follow up)
✅CS Reducer did not improve CMR perfusion metrics, symptoms or quality of life over a sham procedure
❗️QOL w angina probably adequate..
❓was this underpowered
❓was it the wrong population (different mechanisms of CMD)
❓was it the wrong test
@SukhNijjer @rallamee @djc795 @DocSavageTJU @SVRaoMD
Domenico Galante retweeted
@crfheart LBCT
P4 presented by @ColletCarlos
✅ A CCTA-guided PCI strategy was noninferior to IVUS-guided PCI with respect to target-vessel failure at 12 months.
❗️Limitations:
Not complex lesions SS~8
Multiple CT software & high quality scan
Non-inferiority margin wide
Perhaps complementary not competing technologies
👉@NEJM
nejm.org/doi/full/10.1056/NE…
@VDelgadoGarcia @OKhaliqueMD @yadersandoval @sbrugaletta @DocSavageTJU @SripalBangalore @mmamas1973
Domenico Galante retweeted
Presented at #TCT2026:
In a randomized trial, CCTA-guided PCI with structured preprocedural planning and intraprocedural guidance was noninferior to intravascular ultrasound–guided PCI with respect to target-vessel failure at 12 months. Full P4 trial results: nej.md/48jfVly
@crfheart
ALT A graph from the Original Article "Coronary CT Angiography versus Intravascular Ultrasound Guidance for PCI." The trial name, P4, is in parentheses after the title. The graph shows the cumulative incidence of target-vessel failure (primary end point), defined as a composite of death from cardiac causes, target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization, at 12 months. The trial results are being presented at the Transcatheter Cardiovascular Therapeutics 2026 Conference. The logo of the New England Journal of Medicine is at the bottom.
Domenico Galante retweeted
Meta-analyses of intravascular imaging guidance of PCI show markedly improved outcomes, but only if you use this tool properly — pre-, intra- and post-PCI and with appropriate targets. How do you do it? Our new state-of-the-art review in EHJ takes you through it step by step.
Domenico Galante retweeted
Our PROPHET-FFR study now published in Circulation: Cardiovascular Interventions!
Systematic post-PCl functional assessment is associated with a significant reduction in 12-month MACE. 1-Year Results of the PROPHET-FFR Study. Presented @sicigise 47th National Congress and published simultaneously @enromagnoli @GianlucaCampo78
ahajrnls.org/3WrlGLe
Domenico Galante retweeted
Systematic post-PCl functional assessment is associated with a significant reduction in 12-month MACE. 1-Year Results of the PROPHET-FFR Study. Presented @sicigise 47th National Congress and published simultaneously @enromagnoli @GianlucaCampo78
ahajrnls.org/3WrlGLe
Our PROPHET-FFR study now published in Circulation: Cardiovascular Interventions! 🎉
Beyond improving post-PCI physiological results, systematic post-PCI functional assessment appeared to be associated with lower rates of MACE and TVR.
Special thanks to my mentor @AntonioMariaLe2 whose unwavering belief in the value of coronary physiology has inspired this journey for over a decade!
Systematic post-PCl functional assessment is associated with a significant reduction in 12-month MACE. 1-Year Results of the PROPHET-FFR Study. Presented @sicigise 47th National Congress and published simultaneously @enromagnoli @GianlucaCampo78
ahajrnls.org/3WrlGLe
Domenico Galante retweeted
Today, I presented the 1 year results of our PROPHET- FFR study at @sicigise Congress. The systematic use of post PCI physiology improves outcomes. Another step of the #FullPhysiology approach has been proven effective! @FullPhysiol
Systematic post-PCl functional assessment is associated with a significant reduction in 12-month MACE. 1-Year Results of the PROPHET-FFR Study. Presented @sicigise 47th National Congress and published simultaneously @enromagnoli @GianlucaCampo78
ahajrnls.org/3WrlGLe
Domenico Galante retweeted
This is a very important analysis pointing toward the future of vulnerable plaque assessment and lesion selection.
Not everything we once considered “high risk” is necessarily associated with high risk.
The challenge ahead is to identify which plaque features truly matter—and which lesions genuinely warrant intervention.
Domenico Galante retweeted
2026 EHJ - Intracoronary imaging for left main percutaneous coronary intervention: a clinical consensus statement of the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the European Bifurcation Club (EBC)
academic.oup.com/eurheartj/a…
Domenico Galante retweeted
For patients with atrial fibrillation and an intermediate risk for stroke, current guidelines suggest that direct oral anticoagulation should be considered, but data from randomized trials are lacking. Research findings from SINGLE-AF trial are summarized in a Quick Take video. nej.md/4zCtYit
#ESCCongress
ALT A illustration showing anticoagulation for atrial fibrillation with intermediate stroke risk. On the left, a medicine box labeled "Anticoagulant Tablets" with two pills is shown. In the center, a silhouette of a patient with a highlighted heart. Above, a round inset displays a heart rate monitor graph representing atrial fibrillation. To the right, a brain is depicted with an inset showing a blood vessel and a warning symbol, representing intermediate stroke risk.
Domenico Galante retweeted
I will never be afraid to tell fellows how to protect themselves. Unfortunately some trainers prefer to leave fellows alone without correcting them for the position of the table, of the C-arm or even of the x-ray mobile protection. This should represent an important part of training and without it to make a coronary angiography should be forbidden
Just published in #JACCINT: SCAI/ASE/HRS/SIR/SVS Expert Consensus Statement, led by @RizikMd, advises training, monitoring, and calls for mandatory implementation of enhanced radiation protection devices to meet #ALARA standards.
Read the full text here: jacc.org/doi/10.1016/j.jcin.…
Domenico Galante retweeted
Computational FFR is transforming myocardial ischaemia assessment, enabling wire-free physiology and more precise, personalised coronary care.
This State-of-the-Art provides a comprehensive overview of the evolving role of computational coronary physiology, from clinical validation to its integration into everyday practice. It explores current evidence, emerging applications, and future perspectives for CT- and angiography-derived physiological assessment.
eurointervention.pcronline.c…
#CoronaryPhysiology #FFR #PCI
Domenico Galante retweeted
#CoronaryPhysiology
#ESCcongress 2026
Angiography-
Derived
Physiology
/ Complete PCI
in STEMI
More about the
A I R - S T E M I trial
on TCTMD:
🔗 tctmd.com/news/air-stemi-ang…
NFJM manuscript👇
🔗 nejm.org/doi/10.1056/NEJMoa2…
👋
@SimoneBiscaglia
@ColinBerryMD
@Drroxmehran
Domenico Galante retweeted
An incredible number of trials published simultaneously in the NEJM: I honestly can’t quite wrap my head around what is happening. Congratulations to everyone involved. It was difficult to choose only five trials, but these are the ones I selected for the interventional cardiology highlights. #ESCCongress
Domenico Galante retweeted
SIMULTANEOUS PUBLICATION #ESCCongress
SELUTION DeNovo HBR subgroup
In patients at high bleeding risk, a sirolimus-eluting balloon strategy with provisional stenting showed favourable 1-year clinical outcomes compared with systematic DES implantation, while minimising permanent stent use.
#PCI #HBR #DCB
NOW ONLINE 👇
Original article: eurointervention.pcronline.c…
Editorial: eurointervention.pcronline.c…
#PCI #HBR #DCB
@Urphi @DrGarot @JuanFIglesias1 @gabor_gt
What a surprise!
Presented at #ESCCongress:
In patients with suspected acute coronary syndrome without myocardial infarction, routine CT coronary angiography did not result in a lower incidence of myocardial infarction or death from a cardiac cause than standard care. Full TARGET-CTCA trial results: nej.md/4wH7Yk7
@escardio
ALT A figure from the Original Article "Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain." The trial name, TARGET-CTCA, is in parentheses after the title. The figure shows the incidence of myocardial infarction or death from a cardiac cause. The trial results are being presented at the European Society of Cardiology Congress 2026. The logo of the New England Journal of Medicine is at the bottom.
Domenico Galante retweeted
How to approach calcified coronary lesions in contemporary PCI?
This State-of-the-Art review exploreD the role of intravascular imaging and available plaque modification strategies, offering a practical algorithm to guide treatment and optimise PCI results.
eurointervention.pcronline.c…
Domenico Galante retweeted
jacc.org/doi/10.1016/j.jacc.… We need to change the narative from protected PCI to protecting the pt. Complex PCI leads to acute stunning, and the more vulnerable patients may need extented support to allow for recovery-rather than CP removal at the end of the PCI as in BCIS3 #5.5
