Gastroenterologist working to cure the obesity epidemic @MayoClinic. Father of boys, husband, passionate biker 🚴♀️, fútbol fan ⚽️, @UF alumni 🐊
Rochester, MN
Joined May 2011
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We've spent years using GLP-1 therapies. But what if some patients actually have GLP-1 deficiency?
Our new study identifies a distinct obesity subtype with reduced GLP-1 synthesis and enhanced response to tirzepatide—supporting precision medicine
authors.elsevier.com/a/1nRy8…
Andres Acosta retweeted
New commentary in @AGA_Gastro revisits our Practice Guide on Obesity and Weight Management, Education, and Resources framework.
Read more: ow.ly/shBH50ZcOn8
Live webinar 7/15: ow.ly/zlJk50ZcOn9.
@dr_aac @gastrodoc12 @PopovVioleta @PoojaAv721 @gutdoc18 @liver4kids
Andres Acosta retweeted
🗨️ “Gastroenterologists are on the front lines of the #obesity epidemic,” said Dr. Andres Acosta @dr_aac
It follows, then, that they should be involved in treating patients with #GLP1s, he added.
healio.com/news/gastroentero…
Day #4 at #DDW2026
We have an impressive line-up of abstracts.
- Tirzepatide Super-responder SubPhenotype
- LLM for obesity and semaglutide
- ML-GRS for CTS for Bariatric surgery
- ML-GRS for CTS for Phentermine-Topiramate
- LLM for obesity journey
Come to see them!
🌟Rising star @TFredrickMD 🌟 @MayoClinicGIHep Fellow,
Presented at #DDW2026 @AmerGastroAssn our work on GLP-1s, and AEs.
Key take away
- Data in 485 pts treated with GLP1 RA followed for 12 months.
- Constipation as AE is associated with better outcomes.
Great Job!
Excited to be at #OM2026 @OMAsocial Obesity Medicine Association annual meeting to learn, meet old friends, make new friends and off course, talk about phenotyping and genetics for best #GLP1 and other OM responders. #obesity #precisionobesity - @MayoClinic @phenomixscienc1
Excited to arrive at #IFSO2025 @IfsoSecretariat to present about #PrecisionObesity and #PrecisionBariatric: the next Frontier together with @rvcohen. Join us at our early tomorrow morning symposium in beautiful Santiago, Chile. @MayoClinic
Variants of obesity-related genes influence how much weight patients lose on specific weight loss drugs like liraglutide, two studies report.
sciencenews.org/article/gene…
Andres Acosta retweeted
🚨New paper out! After nearly 5 years of learning, growing, and collaborating with brilliant minds, our work is finally published! We explored how individual differences in satiation and genetics can guide personalized obesity treatment. sciencedirect.com/science/ar… #obesity #ATeam
I am delighted to share our new publication in @CellPressNews. We assessed calories to satiation (CTS) and integrated a machine-learning genetic risk score (CTS-GRS) to predict CTS . High CTS or CTS-GRS responded better to Phen-Top; low CTS or CTS-GRS responded to GLP1 (lira)
cell.com/cell-metabolism/ful…
Amazing work from @LizCifuentesMD, @danazcomd and Tim O'Connor.
@MayoClinicGIHep @phenomixscienc1
Andres Acosta retweeted
The closing day of #ECO2025 rewarded stalwarts with excellent insights into the promise of #PrecisionObesityMedicine.
HT: @dr_aac @carel_leroux
conscienhealth.org/2025/05/e…
Wrapping up #DDW2025 day 4 with two great abstracts from our team. @alexticho showing the conservative expression of #GLP1 in the ileum and colon and @marantoec describing weight recurrence after RYGB with a high CTS-GRS. @MayoClinicGIHep @AmerGastroAssn
Excited to win the @DDWMeeting #SharkTank 2025 on behalf of @MayoClinic @MayoClinicGIHep and @phenomixscienc1. We pitched #MyPhenome test and #ESG. Improve outcomes, reduce cost. @ASGEendoscopy @AmerGastroAssn @AASLDtweets
Celebrating our amazing team! Great year of many accomplishments! This team makes it happen! So proud of everyone! @MayoClinic @MayoClinicGIHep @DDWMeeting
Andres Acosta retweeted
Super interesting presentation by @dr_aac - bringing #obesity medicine into the 21st century with genomics 🧬
Precision medicine through genomics is what we need to help move the field forward!
#DDW2025 @DDWMeeting @MayoClinic #GIX #GITwitter
Day2 at #DDW2025 @DDWMeeting Nice to see a familiar fig that remains relevant almost a decade longer in @CNewberryMD #obesity lecture. #POWER Program. Continuity of care, multidisciplinary and comprehensive care @AmerGastroAssn @StreettMd
Andres Acosta retweeted
#DDW2025 4 #Obesity phenotypes
1️⃣Abn satiation:⬆️calories needed for satiation
2️⃣Abn postprandial satiety: ⬆️gastric emptying & ⬆️ postprandial hunger
3️⃣Emotional eating
4️⃣Abn resting energy expenditure
🔺Each phenotypes w distinct #microbiome signature -> potential intervention?
At @DDWMeeting
The next fronteir for obesity phenotypes requires to elucidate the unique microbial signature of each phenotype.
@danazcomd (rising start) showing the data today. Fascinating findings!
