Between physics and biology - Metabolism, microbial ecosystems, origin of life
Boston, MA
Joined April 2009
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Daniel Segrè retweeted
Very excited to report on our lab’s unexpected adventure into subtyping cancer cachexia by way of anatomy, where we study the evolution of the bodies (not the genomes!) of patients with cancer during profound weight loss. Led by Sonia Boscenco. medrxiv.org/content/10.64898…
Daniel Segrè retweeted
How do bacteria organize? 🦠 @BU_Tweets researchers reveal in @CellPressNews that colony shape, metabolism & nutrients drive growth, diversity & striking rings. Learn more: spr.ly/6012AGQbj
Biophysical metabolic modeling of complex bacterial colony morphology: Cell Systems cell.com/cell-systems/fullte…
Daniel Segrè retweeted
Online now: Flux sampling and context-specific genome-scale metabolic models for biotechnological applications dlvr.it/TMNJPL
Daniel Segrè retweeted
This #teamscience effort rose out of C-CoMP's need to collaborate on and integrate genome-informed 'omics data and metadata across time + space for our two model organisms R. pomeroyi and A. macleodii. Congrats to all authors! Read more👇!
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Microbial metabolism operates at the level of pathways, cells, ecosystems. Some quantitative principles hold at multiple scales and may help connect them. Many fun conversations with Daniel Sher (@MCE_lab) and Mick Follows, condensed in a new perspective:
nature.com/articles/s41564-0…
Daniel Segrè retweeted
Our new paper reveals a remarkable ability in marine bacteria: they extract methyl groups from algal metabolites, creating a metabolic shortcut that accelerates the shift from lag phase to growth. Expertly led by @MartinSperfeld and @Narvaez_Delia_
nature.com/articles/s41564-0…
Daniel Segrè retweeted
Article on a phenomenon we refer to as the divergence-complexity effect in #MicrobialCommunities, by Michael Silverstein – collaboration between the labs of @jennymbhatnagar & @dsegre – out at @NatureEcoEvo. nature.com/articles/s41559-0…. What is the idea? 1/2
Daniel Segrè retweeted
🚨Our latest study on #CeliacDisease (CeD) is now live on #bioRxiv! We uncovered crucial insights into the #metabolic malfunction of small intestinal epithelial cells in CeD and identified FDA-approved drugs that can rectify these metabolic abnormalities.
biorxiv.org/content/10.1101/…
Daniel Segrè retweeted
1/n Can LLMs perform scientific research? And, can they do so while enhancing key scientific values including transparency, traceability & verifiability? Check out our preprint on the "data-to-paper" platform. w the amazing @TalIfargan @LostInTranscrip arxiv.org/abs/2404.17605
Daniel Segrè retweeted
Multi-Attribute Subset Selection is an algorithm to identify the most descriptive growth conditions in microbial phenotyping experiments. This streamlines high-throughput phenotyping efforts and helps to reveal biological insights: nature.com/articles/s42003-0…
@segrelab, @YPaschalidis
Daniel Segrè retweeted
Excited to share our latest research on early metabolic evolution, recently published in @NatureEcoEvo! 🧵👇 nature.com/articles/s41559-0… #ScienceTwitter #ResearchHighlight (1/12)
Daniel Segrè retweeted
Our latest publication lead by @RBLVAL is out 🎉 revealing a fascinating collaboration between bacteria and algae! 🌊🧫 We've uncovered how bacteria contribute a polysaccharide to an algal-bacterial shared matrix, promoting aggregation! 🧶🔬
nature.com/articles/s41522-0…
Daniel Segrè retweeted
What happens when integer programming meets the #microbiome? Multi-Attribute Subset Selection (MASS). Joint work with the @dsegre group at @BU_Tweets and my former student @TaiyaoWang in Nature's @CommsBio nature.com/articles/s42003-0…
Daniel Segrè retweeted
New work posted on #biorxiv_biophys: "Biophysical metabolic modeling of complex bacterial colony morphology" biorxiv.org/cgi/content/shor…, based on #COMETS (@RunCOMETS), led by @idouk with Kirill Korolev
Daniel Segrè retweeted
Our paper is out @NatureComms on integrating retina & #GTEx e/sQTLs and single-nucleus RNA-seq from 10 eye tissues @cziscience with GWAS of #glaucoma & eye pressure to uncover disease mechanisms: shorturl.at/twxFS @MassEyeAndEar @HMSEye @broadinstitute @NatEyeInstitute 1/6
Daniel Segrè retweeted
Congratulations to Prof. Yonina Eldar of Department of Computer Science and Applied Mathematics and Prof. @TPilpel of the Department of Molecular Genetics for being awarded the #LandauPrize for Sciences and Arts awarded by Mifal HaPais
Daniel Segrè retweeted
Proud to present our new pre-print on a collaborative, community effort to curate a metabolic reconstruction for Alteromonas macleodii ATC C 27126, a highly flexible marine bacterium biorxiv.org/content/10.1101/…
Daniel Segrè retweeted
Post-doc alert! Interested in microbiology, metabolism and modeling? Want to explore how microbial interactions reduce mortality in the most abundant phytoplankton on Earth? Join our team... tinyurl.com/5n7sw5nu @HaimTreves @dsegre @segrelab Please RT
Daniel Segrè retweeted
estuaries + sediment + fluxes + microbes = joy! Check out this postdoc position: tinyurl.com/5fmr78b2
@dsegre @BuMicrobiome @aslo_org @BlackinMarSci @CERFScience @ISME_microbes @WHOI @MBLScience