.#AI turns amazing developers into superhumans. This is not a bad thing, but the art of development is a very personal thing. I can understand the backlash in some corners of the tech world. I for one, welcome our new robot overlords. 🤖
DHH is probably one of the top software artisans of the past decade. Hearing him speak with this much conviction and transparency about one of the most polarizing topics in software right now, writing code by hand vs. with AI, is something pretty much every software engineer should hear a few times.
Especially those still on the wrong side of history.
Joe Dustin retweeted
🚨 Yarchi just published an awesome guide on building an AI "second brain" using Claude and Obsidian
Based on @karpathy's LLM Wiki concept, the idea is to stop starting from a blank chat window and start building a compounding knowledge graph.
Obsidian handles the local storage.
Claude acts as the brain.
I wrote down the condensed notes on how to wire them together:
The Stack:
→ Install Obsidian (your free, local text storage) and Claude Desktop Pro (the engine that reads and writes files).
The Bridge:
→ Install the "Local REST API" plugin in Obsidian, copy the key, and use Claude’s MCP framework to connect them (claude mcp add-json obsidian-vault...).
The Context:
→ Ask Claude to interview you. Have it ask about your goals, projects, and working style, then save it all to a CLAUDE.md file so it never forgets who you are.
The Structure:
→ Create specific project folders (Inputs, Process, Outputs, Feedback) and open them as isolated vaults so Claude stays focused on one job at a time.
The Automation:
→ Save repeated workflows as markdown "skills" and use Claude's schedule tab to trigger daily vault maintenance.
Voilà!
You end up with an AI that organizes your files, summarizes your notes, and remembers your entire context.
Full guide from Yarchi here ↓
I built a fake AI company for April Fools Day. Here is what I learned from it. #ClincalTrials #eClinical linkedin.com/pulse/i-built-f… via @LinkedIn
The DIA 2026 Global Annual Meeting has been reimagined — and I'm proud to say I helped build it!
As part of the Program Committee, I've seen firsthand the work that's gone into designing something truly different: new learning formats, p… echo.walls.io/sC6z431
Check out my latest article: What Life Sciences Leaders Need to Know About America's AI Action Plan linkedin.com/pulse/what-life… via @LinkedIn
Check out my latest article: What you need to know about the New FDA Priorities if you work in #ClinicalTrials linkedin.com/pulse/what-you-… via @LinkedIn
Joe Dustin retweeted
Our Joe Dustin has a unique role overseeing both clinical #innovation and #changemanagement. Learn about Joe, who was named to @PharmaVOICE’s 2021 #PharmaVOICE100 list, and how he’s making an impact for patients: bit.ly/2TSM80B
It's Friday - want to talk Healthcare and Research? We're trying out X Spaces. nitter.cf/i/spaces/1BRJjwnyrZpxw
Chatting about @memrhealth on Spaces right now. #Clinicaltrials matching with automated record retrieval from #EMR in new ways with #AI agents going deeper into the data. Very cool.
Finally met this guy in person in NYC last week. It was great to share a meal and share aspirations for 2025 with @joao_b #DigitalHealth #Wearables #ClinicalTrials – at New York, NY
Support Christine Von Raesfeld: Advocate for Patients gofund.me/72e61422
PAC MAN.... the UFO is PAC MAN.
Image released of mysterious object shot down over Yukon in 2023 ctvnews.ca/canada/image-rele…
Remember the former headquarters of @Merck in Whitehouse Station NJ? It feels post apocalyptic to what it once was. See this on LinkedIN. linkedin.com/posts/eclinical… – at New Jersey, USA
Hey @TheUPSStore - I used the auto returns machine for the first time today in your Raritan NJ store. Suggest you have a dedicated person to help first timers get it right without frustration and then people will be excited to not wait for returns!
Joe Dustin retweeted
My POV is there are two areas where startups are currently focusing:
- UI to access a back-end platform that has aggregated a variety of foundational models and knows which one to call
- fine-tuning of foundational models for very specific use cases
Basically the top 3 layers.
Do Epic Shit :). #SpaceX













