Hong-Hee Won

Nice systematic analysis of gene convergence between common and rare variant GWAS discoveries. Not often we see common and rare variant studies implicating the same set of genes for a trait. This convergence is rare particularly for traits under strong selection like early onset neuropsychiatric diseases. However, if we take a step backward, we can see that, even though common and rare disease variants do not converge on the same genes, they do converge on the same pathways. Analyzing 373 phenotypes with both common and rare variant discoveries available, the authors find that genes implicated by rare and common variants implicate the same pathways for >75% of traits. Paper: Wright et al. Common and rare genetic variants show network convergence for a majority of human traits. medRxiv 2025 medrxiv.org/content/10.1101/…