Hui Chen retweeted
Excited to share new work from our lab that uncovers mechanisms regulating genome activation in early development. Heroic effort from @hui_chen2 to spatially map nascent transcriptome, and uncover precocious ZGA. Out online @CurrentBiology. Free access: authors.elsevier.com/a/1fe3c…
Our preview @Dev_Cell for the beautiful work on nuclear size control by perinuclear ER from the labs of Nicolas Minc and Dan Levy. Congrats to Nicolas and Dan!
Preview in this issue of Dev Cell: Nuclear sizER in Early Development - zpr.io/HpwKR
Our method on imaging single-cell nascent transcription in wholemount early embryos to reveal a novel spatial pattern of ZGA. Special thanks to @jbwallingford and @mechmorph for their pioneering imaging techniques, @XenopusNXR for training and @CDBMicroCore for technical support.
Our methods paper is online describing imaging of nascent transcription in whole-mount blastula embryos. sciencedirect.com/science/ar…
This details the approach used in Hui's 2019 Dev Cell paper to identify a spatially graded pattern of genome activation in Xenopus early embryogenesis
First time attending the @___SDB___ meeting #2019SDB and it was my great honor to present in the BEST Hilde Mangold Postdoctoral Symposium. Many thanks to you
@SolnicaKrezelL @Planaria1 @JeffreyAFarrell Tania, Natalia and @DevelopmentalDy.
Hui Chen retweeted
There is a transition during early development when an embryo undergoes biochemical changes, switching from being controlled by maternal molecules to being governed by its own genome, according to new @PennMedicine research. bit.ly/2XAQQA3
Hui Chen retweeted
Spatiotemporal Patterning of Zygotic Genome Activation in a Model Vertebrate Embryo cell.com/developmental-cell/…
Hui Chen retweeted
Transitions: @PennMedicine, @PennCDB Matt Good and Hui Chen describe in @Dev_Cell that the awakening of an embryo’s genome does not happen all at once, instead follows a pattern controlled by the various sizes of its cells. @NIH, @BWFUND, @MarchofDimes. bit.ly/2IorqNq
Hui Chen retweeted
Hui's paper on spatial patterning of zygotic genome activation was published as cover story in Developmental Cell (cell.com/developmental-cell/…). Also highlighted in Penn News (pennmedicine.org/news/news-r…).
