Immunoengineer @MITdeptofBE finding new ways to MEASURE and interpret #inflammation #SexDifferences #ChronicLyme #LongCOVID. Mom of 2. prev/ @Yale, @Stanford.
Massachusett land
Joined October 2016
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Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
medrxiv.org/content/10.1101/…
Michal Tal, PhD retweeted
I've experienced really positive effects on my energy levels and dysautonomia. Unfortunately, the impact on my sleep quality has been disastrous, which is a major issue for me.
Michal Tal, PhD retweeted
We know that amantadine is primarily eliminated by the kidneys, so it may be useful to assess and monitor renal function to better understand its effectiveness and individual treatment response.
Michal Tal, PhD retweeted
Yuri Kim from @ImmunoFever's team presenting at the RECOVER TLC meeting about their MAESTRO project. This was Righteye eye tracking.
We saw interesting Righteye results in our #InnovationInn project. Here's an example of pre vs during post-exertional malaise.
Michal Tal, PhD retweeted
We're proud to partner with @ImmunoFever @mhornig @MIT_TRG @TomerTalVH and @technopolymath on this exciting program! @amyrochlin
Sounds like the big prizes for TOPx will be announced tomorrow! Thank you all for your efforts!
Meanwhile, check out the newest video short from my awesome student Caleb explaining capillaroscopy with blood flow in 32 seconds!!! I'm so impressed @MIT_TRG
youtube.com/shorts/Mi8mxzF3Q…
Michal Tal, PhD retweeted
📝 #GUTBlog | Could screening help pave the way for Crohn’s disease prevention?
Turner et al explore how faecal calprotectin can help define preclinical stages of Crohn’s disease in asymptomatic first-degree relatives, proposing a screening framework to support future prevention trials.
📄 "Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials"
📝 Read the #GUTBlog: bit.ly/3UkCNxM
🔗 Read the paper in Gut: bit.ly/4zLZWYY
#CrohnsDisease #IBD #FaecalCalprotectin #PreventionResearch
Michal Tal, PhD retweeted
Is your doctor still telling you your diet isn’t important when you have IBD??
Congrats to @SunHoLee15 @KenCroitoru @The_GEMProject for another important step on the journey to preventing IBD.
📝 #GUTBlog | Could screening help pave the way for Crohn’s disease prevention?
Turner et al explore how faecal calprotectin can help define preclinical stages of Crohn’s disease in asymptomatic first-degree relatives, proposing a screening framework to support future prevention trials.
📄 "Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials"
📝 Read the #GUTBlog: bit.ly/3UkCNxM
🔗 Read the paper in Gut: bit.ly/4zLZWYY
#CrohnsDisease #IBD #FaecalCalprotectin #PreventionResearch
Michal Tal, PhD retweeted
Very excited to introduce Paperclip Datasets!
Curate your own datasets from millions of papers in minutes. Just describe the dataset you want to build!
As example, we release the largest dataset of 20k half-life human measurements curated from 2400+ drugs💊
🖇️ Try it: paperclip.gxl.ai/datasets
📝 Blog: gxl.ai/blog/introducing-pape…
📊 Half-life dataset: huggingface.co/datasets/gxl-…
Sounds like the big prizes for TOPx will be announced tomorrow! Thank you all for your efforts!
Meanwhile, check out the newest video short from my awesome student Caleb explaining capillaroscopy with blood flow in 32 seconds!!! I'm so impressed @MIT_TRG
youtube.com/shorts/Mi8mxzF3Q…
Michal Tal, PhD retweeted
A small molecule improves the fitness of cells containing diseased mitochondria.
Learn more in a new #SciencePerspective: scim.ag/4jOhL50
Michal Tal, PhD retweeted
2/ The puzzle: CD19-CAR T cells produce sustained drug-free remission in severe autoimmune disease. Antibodies against the same B cell lineage rarely do.
Both deplete B cells. So what does CAR T remove that antibodies leave behind?
Michal Tal, PhD retweeted
CD19-CAR T cells clear the EBV-infected B cells that carry autoreactive antibodies. Rituximab doesn’t. That may be why only one of them produces lasting remission.
New Robinson Lab preprint led by me and @panditmahes. 🧵
biorxiv.org/content/10.64898…
Michal Tal, PhD retweeted
Stanford researchers studied 27 autoimmune patients and found CD19 CAR T-cell therapy cleared EBV-infected, autoreactive B cells that resisted rituximab.
8 of 12 CAR T-cell patients achieved sustained drug-free remission.
biorxiv.org/content/10.64898…
Michal Tal, PhD retweeted
🚨 New preprint alert 🚨
Using our developments in multispectral imaging we ask: how does the organelle network rewire in killer T cells as they kill cancerous target cells? 🧵
Michal Tal, PhD retweeted
I am so incredibly grateful for the NIH funding for our endometriosis NAMs Technology Development Center, where we are working with industry partners to move new EFFECTIVE endometriosis drugs into the clinic. It is my dream of decades, to help women and girls avoid the horrible pain and other gross symptoms I endured, by bringing new targeted therapies into the clinic.
Under @POTUS and @FLOTUS' leadership, women's health is finally getting the attention it deserves. 🇺🇸
From menopause care and lower fertility drug costs to maternal health and research, HHS is advancing women's health at every stage of life.
See the results: hhs.gov/press-room/wtas-hhs-…
Michal Tal, PhD retweeted
Voting for TOPx closes on Thursday, so cast your votes now!!!
invisibleillness.crowdicity.…
In the meantime, look at what happens when we cut off blood flow under a capillaroscope!
youtube.com/shorts/Mi8mxzF3Q…
Michal Tal, PhD retweeted
Headed to RECOVER TLC with a suitcase full of Vagis rings!
2nd rings for @doc4care
@NovaSupport and Isabel to run experiments with rings on both hands, some for @ImmortalSaKe and Dr Yellman, and two are headed to @ImmunoFever.
Isabel is also bringing a capillaroscope that she got from Mikki and we have Lumias and my whole stack of wearables and devices. We're going to have to take over a table at the meeting to show everyone all the gear. 😆
@BrainstemMd
Who will be at RECOVER TLC this week?
Some of our team will be there and we would love to meet people!
Isabel, @doc4care, @tessfalor, @NovaSupport, @ImmortalSaKe, and Dr Brayden Yellman will all be attending.
If you can't attend in person, there is also a streaming option. Register here: web.cvent.com/event/e0be4010…
Michal Tal, PhD retweeted
Sustained low-level #inflammation is a hallmark of the #aging process. The accumulating damage persistently activates the innate immune system - the body’s first line of defense - leading to what is known as inflammaging, functional decline and chronic diseases of old age.
Unlike the adaptive #immunesystem, which switches on and off based on the specific pathogens it recognizes, innate immune sentinels such as macrophages can recognize a diverse array of danger signals. The mechanism of this pattern recognition has remained an enigma, however.
In a new study published Oct. 23 in Cell, researchers at Yale School of Medicine found that the amino acid #taurine is key to the way the innate immune system senses danger signals. Even more, boosting taurine levels may diminish the effects of inflammaging.
Read more here: medicine.yale.edu/news-artic…
Michal Tal, PhD retweeted
Hi everyone, we’ve been working on something 🙏🏼 I’ve written a second letter to Andy Burnham, alongside 360 sports people, to urge him to meet with me and fund research into my much neglected health issue which impacts millions of others.
I can’t believe 360 people signed in just 1 week, so many amazing names and messages still coming in of people wanting to add theirs (so feel free to message to add yours, we’re keeping on the pressure!!!)
The list includes 114 Olympians, with 77 medals between them (and that’s not even including Worlds and Europeans 🤯). Also some huge names from football and many other sports!!
Thank you SO much to everyone that signed, I can’t tell you how much it means to me when I’m truly at rock bottom ❤️❤️❤️
I know everyone wants their issues taken seriously, but this has been neglected like nothing else. WE HAVE 0 APPROVED TREATMENTS!!! Please listen 🙏🏼 @andyburnham @number10gov @UKLabour @DHSCgovuk
Michal Tal, PhD retweeted
Interessante Studie, die in einer sehr selektionierten Population mögliche Ursachen für den immer wieder berichteten Thoraxschmerz bei ME/CFS herausarbeitet.
Auch die reduzierte periphere Sauerstoffextraktion konnte im iCPET gezeigt werden.
journals.physiology.org/doi/…
Michal Tal, PhD retweeted
A new @ScienceAdvances study proposes the Bacillus Calmette-Guérin vaccine as a preventative measure against dementia.
The vaccine reduces Alzheimer’s-associated phospho-tau proteins, reprograms myeloid immune cells and limits neuroinflammation. scim.ag/47Dk9nR
ALT A comparative illustration of neuroinflammation in PS19 FTLD-tauopathy versus BCG-treated PS19 conditions. On the left, PS19 FTLD-tauopathy features reactive astrocytes, activated microglia, and proinflammatory cytokines, leading to neuronal degeneration, tau protein tangles, and cognitive decline as shown by a distressed mouse icon. On the right, BCG-treated PS19 shows resting microglia, healthy neurons, and a stabilized environment with reduced neuroinflammation and improved cognitive function, represented by a healthier mouse icon.