Microbiologist & phage phanatic! Enthusiastic explorer of microbial genomes. New PI at the Wadsworth Center. Currently obsessed with plasmid-dependent phages
Boston, MA
Joined October 2009
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Siân Owen retweeted
So we did a similar experiment with conjugative plasmids and found that IS605 provides offensive and defensive benefits to conjugative plasmids, acting like a primitive anti-self defense mechanism to spread plasmids between cells.
Siân Owen retweeted
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my colleague @fernpizza showed how plasmids compete intracellularly (check out his paper just published in Science today!). Together with @baym, we now know how they can fight.
Siân Owen retweeted
Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @implosian, @baym, @nquinoneso, Kesther and Carmen! biorxiv.org/content/10.1101/… 1/
Siân Owen retweeted
Nature News piece on the hidden players of the gut microbiome (hint, they're phages, of course)
“Our virome is hugely abundant and incredibly diverse, and we’ve looked at just a tiny percentage,”
nature.com/articles/d41586-0…
Siân Owen retweeted
Centers for Accelerating Phage (Bacteriophage) Therapy to Combat ESKAPE Pathogens (CAPT-CEP) (P01 Clinical Trial Not Allowed) dlvr.it/TFfcWx
Siân Owen retweeted
🚨We're hiring a lab manager/research scientist!
Come work with us @MSU_MicroImmuno at Montana State in beautiful Bozeman, MT
We are a phage lab with diverse projects related to infectious disease, check us out here: patsecor.wixsite.com/mysite-…
apply here: jobs.montana.edu/postings/43…
Siân Owen retweeted
doi.org/10.1016/j.mib.2024.1…
@vivek_mutalik and @simroux_virus, this is your new graphical abstract:
Siân Owen retweeted
Some partnerships are always fun!! Excited to share one such 🎉 product w @simroux_virus perspectives on our favorite “atypical” phages, for special issue to celebrate my former mentor Carol Gross @UCSF
Tapping the treasure trove of atypical phages sciencedirect.com/science/ar…
Siân Owen retweeted
Come see Amy at poster 174 & learn about how active prophages may change the trajectory & evolution of resistance to DNA damaging antibiotics 💊 ⚡️ #EMBOEvoEco
Siân Owen retweeted
Fellow microbial immunity, mobile elements, and plasmid enthusiasts: the paper of our wonderful @BruriaSamuel on anti-defense genes in plasmids is now published in @Nature!!!
Check out her thread below for highlights of our new results.
1/2
Meet The Shielded Plasmid🛡️🧬
Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation.
It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency🧵(1/7) nature.com/articles/s41586-0…
ALT Illustrated by @Irisburstein
Siân Owen retweeted
The Bartlett Lab is open for business at the Wadsworth Center! We study pathogens with "unusual" shapes (balls & corkscrews) to find vulnerabilities in their growth plans, and learn how bacterial shape impacts infection. We are hiring... join us!
wadsworth.org/research/labor…
Siân Owen retweeted
I'll be speaking about viral sociality at TEDxNewEngland on Wednesday 25th September, alongside a great lineup of other speakers.
List of speakers & tickets here for anyone in the Boston area who might want to come: tedxnewengland.com/speakers
#TEDxNE #SocialViruses #LoveVirology
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Siân Owen retweeted
Multiplexed editing of phage genomes using retrons, now published at @NatureBiotech with lots of new bells and whistles. @ChloeFishman @katecrawdaddy @BhattaraiKline @Darshini_Poola @thekarenzhang @alex_gonzadel @matromont
nature.com/articles/s41587-0…
Siân Owen retweeted
So glad to see this out!
It was definitely a labor of love, but it has become my new blueprint of how I think about AMR evolution. We aimed to highlight how much we've learnt as a field, and especially, how much we still *don't* know 1/4
Thrilled to see the first review article from my lab out in advance @AnnualReviews, helmed by @Celia_Sqe: From Petri Dishes to Patients to Populations:
Scales and Evolutionary Mechanisms Driving Antibiotic Resistance
annualreviews.org/content/jo…
Siân Owen retweeted
Faculty search! @YaleMicroPath is looking to hire assistant professor(s) focused on the pathogenesis of viral, bacterial, parasitic, or fungal infections. Info: apply.interfolio.com/151755. Q&A webinar in Sept. Please RT!
Siân Owen retweeted
ePhective (San Francisco) is a newly founded #phagetherapy company started by @joeBondyDenomy (@UCSF) & Zemer Gitai (@Princeton). They are currently looking for:
2 #Phage Scientists to lead projects in phage discovery, characterization, & engineering
Siân Owen retweeted
I am absolutely delighted to be joining the University of British Columbia next year as an Assistant Professor @ZoologyUBC.
We will study social evolution in viruses.
Siân Owen retweeted
Nature research paper: In situ targeted base editing of bacteria in the mouse gut go.nature.com/3VW8iuJ
Siân Owen retweeted
🚨Are you interested in exploring the fascinating world of RNA phages? We are recruiting a PhD student and a postdoc to join us @Helmholtz_HIRI!
Please spread the word!
More info:
helmholtz-hiri.de/en/jobs-ta…
