Jayna Mistry (@jaynathemistry) header
Jayna Mistry (@jaynathemistry) profile picture

Jayna Mistry

@jaynathemistry

Group leader at Norwich Medical School @uniofeastanglia | Blood 🩸 bone marrow 🦴 and bad puns 😬 .

 Norwich, England
Joined November 2018
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  • Following241
  • Followers263
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Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)Photo by Jayna Mistry (@jaynathemistry)
Can we interrupt the inflammatory signals driving clonal hematopoiesis? Our new study, led by @jaynathemistry, identifies neutrophil-derived S100A8/A9 as a potential therapeutic target to limit DNMT3A-mutant stem cell expansion. @Haematologica doi.org/10.3324/haematol.202…
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Made it to Chicago and excited for #ISEH2024! I will be presenting our work in a talk on Friday and @jaynathemistry has a poster on Saturday - don’t miss it! Let’s go! 🙌
ISEH (@ISEHSociety) profile pictureISEH@ISEHSociety26 Jul 2024
We look forward to hosting you in Chicago for #ISEH2024! Taking place at the Sheraton Grand Chicago Riverwalk, we will be steps away from restaurants, theaters, museums and @NavyPier. Take advantage of your stay in addition to the ground-breaking science! iseh.org/2024Travel
Image from ISEH (@ISEHSociety)
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🔥🔥Excited to share our work on Non-canonical Hedgehog signaling in #MPNsm. We here demonstrate the role Gli1 as an important transcription factor in MPN and the mechanism by which non-canonical Hh signaling through Gli1 contributes to #fibrosis ⁦👇🏼👇🏼 cell.com/cell-reports/fullte…
Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloprol...

Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloprol...

Pritchard et al. show that increased Gli1 protein levels in MPN patient blood cells mark fibrotic progression. By systematically interrogating the role of canonical vs. non-canonical Hedgehog...

cell.com
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Fantastic day sharing science & technology ideas & inspirations, good food, fresh air & exercise at our lab retreat. So lucky to work with this fabulous group of people!!! @jaynathemistry @Dr_YoungBlood
Image from Jennifer Trowbridge (@TrowbridgeLab)
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Happy Halloween from the Trowbridge lab! Blood and bones; vampires and skeletons. Inspired by @theclotthickens 🩸🦴🩸🦴
Image from Jennifer Trowbridge (@TrowbridgeLab)
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📣 Fully Funded @NRPBIODTP #PhD: One in a million: studying #platelet heterogeneity using #singlecell #genomics🩸 Working with Dr Edyta Wojtowicz, @WHaerty, and @EI_single_cell. 🗓 Applications close: 20 November okt.to/18cYiJ
Dr Edyta Wojtowicz holding up and looking closely at a a sequencing plate

ALT Dr Edyta Wojtowicz holding up and looking closely at a a sequencing plate

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Congratulations to our @jacksonlab SSP student David Bernal from Wash U & mentor @jaynathemistry on a very successful summer project!! 🙌 We will miss your enthusiasm & humor David!
Image from Jennifer Trowbridge (@TrowbridgeLab)
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Work led by the brilliant @ewojt2 is out today in @GenomeBiology !🥂🧬🩸thank you for the opportunity to be involved in this awesome work 🥰
Image from Anita Scoones (@AnitaScoonesPhd)
ewojtowicz (@ewojt2) profile pictureewojtowicz@ewojt227 Jun 2023
Replying to @ewojt2
Many thanks to @wellcometrust @whatchamacaulay @RushworthLab @WHaerty @KrisBowles7 @jaynathemistry @c_hellmich @AnitaScoonesPGR @EarlhamInst and all co-authors
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Jayna Mistry retweeted
ewojtowicz (@ewojt2) profile picture
ewojtowicz@ewojt227 Jun 2023
Happy to share my postdoctoral work now published in @GenomeBiology Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion, doi:10.1186/s13059-023-02976-z Thank you!
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The Dumont lab is proud to share that our talented postbacc Kimberly Heath-Borrero will be pursuing an MD/PhD with a track in Cell and Cancer Biology at The University of Toledo. We are excited for what is to come, and we will miss Kim in the lab. @JAX_Education @jacksonlab
Image from Dumont Laboratory (@Dumont_Lab)
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Here's the link to the preprint: biorxiv.org/content/10.1101/… This was such an incredible experience to work with amazing co-authors, and two incredible senior authors @garethhowell10 and @ErikBloss! @jacksonlab @JAX_Education @TuftsGSBS
Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer’s...

Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer’s...

Common features of Alzheimer’s disease (AD) include amyloid pathology, microglia activation and synaptic dysfunction, however, the causal relationships amongst them remains unclear. Further, human...

biorxiv.org
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I’m very happy to announce that I will be joining the @YaleIBIO to pursue my PhD in Immunology. I feel grateful for all the support from my mentors, family and friends. So excited for this new journey! #rePRsentando 🇵🇷
JAX Genomic Education (@JAX_Education) profile pictureJAX Genomic Education
@JAX_Education6 Apr 2023
🎉 We are thrilled to announce Patricia Colom Díaz, a postbac fellow in the @Trowbridgelab at @jacksonlab, will be pursuing a Ph.D. in Immunology at @Yale! She was awarded the Dean's Emerging Scholar Fellowship by the program. Congratulations, Patricia!
Patricia, wearing a light gray Yale sweatshirt and black pants, stands in front of the ocean.

ALT Patricia, wearing a light gray Yale sweatshirt and black pants, stands in front of the ocean.

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Welp I'm officially a FULL PROFESSOR!!! Little undergrad me would have never believed this. What a privilege to be on this journey. Grateful to all of my lab members past and present, mentors, allies, friends, family... wouldn't be here without all of you 🥰
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Excited to share my PhD research now published in @BloodJournal 🎉🎉 Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression: doi.org/10.1182/blood.202201… Thank you to all! @c_hellmich @RushworthLab @KrisBowles7 @bigctweets
Image from Aisha Jibril, PhD (@Aisha_Jibril_)
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Really proud of postbacc student @ColomPatricia_ and postdoc @jaynathemistry for putting together an excellent review article and perspective on the relationship between HSC aging and leukemia transformation 🤩 Check it out online now in @BloodJournal! bit.ly/3xLqawK

Hematopoietic stem cell aging and leukemia transformation

Edited by Associate Editor John Crispino, this Review Series focuses on hematopoietic stem cell (HSC) biology, going beyond the work in murine HSC biology

ashpublications.org
Hematopoiesis News (@Hema_News) profile pictureHematopoiesis News
@Hema_News24 Feb 2023
👏 Congratulations to the @TrowbridgeLab from @jacksonlab on their latest review on HSC #aging and #leukemia transformation! They provide an update on processes recently found to contribute to functional decline of #HSCs during aging! @BloodJournal | bit.ly/3xLqawK
Image from Hematopoiesis News (@Hema_News)
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Excited my review with @Dumont_Lab and @mathandel on mammalian reproductive genomics is out in @Dev_journal! We highlight some research strategies that I'm excited about, including multiparent populations and treating fertility as a quantitative trait! doi.org/10.1242/dev.201313
Fig. 2. Genetic strategies in mouse fertility research. (A-C) The left panel illustrates the single-gene strategies discussed in the main text. These include: exploiting spontaneous mutant phenotypes (A), where the black extremities represent a visible morphological phenotype; targeted mutagenesis strategies, including CRISPR editing (B); and unbiased random ENU mutagenesis (C). (D-F) The right panel illustrates strategies that take advantage of genetically diverse strains of mice to detect genes controlling reproductive parameters. As discussed in the main text, the standard inbred strains (D) exhibit considerable diversity in quantitative parameters of gamete production and function. These strains can be interbred to form F1 hybrids (E), which often can identify dominant traits. Further intercrossing of hybrids (F) leads to bi-parental recombinant inbred strains and the multiparent strains with representation of several input genomes. See more at https://doi.org/10.1242/dev.201313

ALT Fig. 2. Genetic strategies in mouse fertility research. (A-C) The left panel illustrates the single-gene strategies discussed in the main text. These include: exploiting spontaneous mutant phenotypes (A), where the black extremities represent a visible morphological phenotype; targeted mutagenesis strategies, including CRISPR editing (B); and unbiased random ENU mutagenesis (C). (D-F) The right panel illustrates strategies that take advantage of genetically diverse strains of mice to detect genes controlling reproductive parameters. As discussed in the main text, the standard inbred strains (D) exhibit considerable diversity in quantitative parameters of gamete production and function. These strains can be interbred to form F1 hybrids (E), which often can identify dominant traits. Further intercrossing of hybrids (F) leads to bi-parental recombinant inbred strains and the multiparent strains with representation of several input genomes. See more at https://doi.org/10.1242/dev.201313

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Check out tonight’s poster 4100 from our lab discovering a functional role for metallothionein in DNMT3A;NPM1-mutant AML! #ash2022 @ColomPatricia_ @jaynathemistry
Image from Jennifer Trowbridge (@TrowbridgeLab)
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If you are attending #ASH22 come along to my presentation!
Jennifer Trowbridge (@TrowbridgeLab) profile pictureJennifer Trowbridge@TrowbridgeLab11 Dec 2022
So excited for @jaynathemistry to present her fantastic work on CHIP & senescence in the microenvironment. 12:45pm today in session 506 room 260. Don’t miss it!! 🔥
Image from Jennifer Trowbridge (@TrowbridgeLab)
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What are the essential metabolic changes that promote CHIP? And are they therapeutically tractable? Stop by @Dr_YoungBlood’s poster 1222 tonight to find out!! #ASH2022
Image from Jennifer Trowbridge (@TrowbridgeLab)
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