Inserm Research Director & Editor-in-Chief of Oncogenesis studying how tumor metabolism shapes anti-tumor immunity and cancer therapy resistance.
Nice, France
Joined April 2012
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Jean-Ehrland Ricci retweeted
Check how this study identifies TRX1 Cys35 as a critical target of acrolein and establishes the acrolein–TRX1–p38 axis as a novel link between oxidative stress and neutrophil-mediated immunosuppression, highlighting this pathway as a promising therapeutic target in GBM.
Jean-Ehrland Ricci retweeted
“Acrolein- thioredoxin 1- p38 signaling drives neutrophil-mediated immunosuppression and glioblastoma progression”
🔵 Hsiang-Tsui Wang‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how using modulators targeting NRF2-regulated pathways to induce ferroptosis in cancer cells, or leveraging NRF2 activity as a biomarker to identify ferroptosis-susceptible tumors, NRF2 may serve as a critical bridge to translate ferroptosis into clinical application.
Jean-Ehrland Ricci retweeted
“Tipping the balance: NRF2’s dual role in ferroptotic fate”
🔵 Excited to share the latest review from Clarissa Rocha, now available in #Oncogenesis.
▶️ Read the full review here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how the authors show that blocking CD44v5 not only alleviates signaling pathway -dependent resistance but also enhances cisplatin sensitivity by directly promoting ferroptosis, suggesting that CD44v5 is a potential therapeutic target for reversing chemoresistance in TNBC.
Jean-Ehrland Ricci retweeted
“CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11”
🔵 Chun Yang‘s latest research is now available to read in #Oncogenesis.
▶️ Read the open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Reminder that xCT-driven cell death (for instance induced by glucose deprivation) does not mean disulfidptosis,
That iron-dependent cell death does not equal ferroptosis,
That cysteine toxicity does not mean ferroptosis even if it's iron-dependent,
etc
nature.com/articles/s42255-0…
Jean-Ehrland Ricci retweeted
Check how this study reveals that STC1 is a key regulator of GSC phenotypic plasticity and aggressiveness through the NOTCH1/STAT3/GFPT2/O-GlcNAcylation pathway, suggesting that targeting STC1-associated signaling networks may represent a potential therapeutic strategy for GBM.
Jean-Ehrland Ricci retweeted
“Stanniocalcin 1 contributes to glioma stem cells phenotypic plasticity through NOTCH1/STAT3/GFPT2 axis”
🔵 Shuo Xu‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how their findings establish a novel Testican-1/Wnt/β-catenin axis driving CRC tumorigenesis and progression, positioning it as a promising therapeutic target to overcome Wnt-mediated progression and resistance.
Jean-Ehrland Ricci retweeted
“Testican-1 activates Wnt/β-Catenin signaling to drive colorectal cancer progression”
🔵 Nathaniel Weygant‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how, in this study, they revealed that CYBRD1 is a druggable transmembrane protein in HGSOC whose RUNX1-driven, Tyr252-dependent activation of JAK2/STAT3 promotes tumor progression and cisplatin resistance.
Jean-Ehrland Ricci retweeted
“CYBRD1 is transcriptionally regulated by RUNX1 and mediates JAK2/STAT3 signaling activation during ovarian cancer progression”
🔵 Jingxin Cheng‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
Mitophagy is everywhere in cancer reviews but rarely studied in vivo. We tracked it during lung tumor development and show that PINK1-dependent mitophagy is activated early during transformation and is a targetable vulnerability in KRAS lung cancer.
science.org/doi/10.1126/scia…
Jean-Ehrland Ricci retweeted
This review highlightes how genetic alterations influence metabolic phenotypes, how insights from therapeutic efforts targeting individual metabolic branches can inform a unified strategy to exploit metabolic weaknesses and guide the rational development of combination therapies.
Jean-Ehrland Ricci retweeted
“Metabolic vulnerabilities in pleural mesothelioma”
🔵 Pleased to share the latest review from Cristina Muñoz-Pinedo (@crismunozp) & Ernest Nadal (@apoptosislab ), now available in #Oncogenesis.
▶️ Read the full review in open access here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
The authors synthesise current knowledge into a conceptual model and highlight nucleotide metabolism as a central, drug-responsive nexus linking oncogenic signalling to malignant proliferation.
Jean-Ehrland Ricci retweeted
“The oncogenic control of nucleotide synthesis”
🔵 Excited to share the latest review from Issam Ben-Sahra (@bensahralab), now available in #Oncogenesis.
▶️ Read the full review here: nature.com/articles/s41389-0…
Jean-Ehrland Ricci retweeted
Check how the authors uncovered a metabolic-epigenetic signaling cascade in the lung tumor microenvironment whereby tumor-derived lactate activates CAFs and enables them to induce an immunosuppressive macrophage phenotype via exosomal miR-214-5p.
Jean-Ehrland Ricci retweeted
“Lung adenocarcinoma cell-derived lactate activates CAFs to promote macrophage M2 polarization via exosomal miR-214-5p”
🔵 Bin Li‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: nature.com/articles/s41389-0…
