jonnysexton retweeted
@jonnysexton teaching us about the challenges and limitations of predicting #DILI in vitro and how patient-derived organoids can overcome many of these at the #IQDILI meeting. Tangential flow and MPS models increase physiologic relevance. Beautiful images and cutting edge science @livertox @RobertFontanaMD @TFFVIIa @rajVuppaLanchi
Super interesting - we just published a paper in Nature Cell Discovery with our colleagues at Henry Ford showing that SARS-CoV-2 can infect macrophages, but only if they are angry!
Inflammatory stress causes Ace2 to translocate to the cell surface. Wow.
nature.com/articles/s41421-0…
We found that a series of drugs inhibits the SARS-CoV-2 cell-to-cell spread mechanism by single-cell high content screening & morphologic cell profiling - fewer infected cells and the viral protein builds up inside. This halts the infection!
biorxiv.org/content/10.1101/…
ALT Niclosamide halts SARS-CoV-2 Infection
Considering testing Niclosamide for Covid-19?
It will likely not work but some improved analogs might:
biorxiv.org/content/10.1101/…
We all learned a lot about drug repurposing during the pandemic - here are some thoughts:
theconversation.com/repurpos…
jonnysexton retweeted
Congrats to our own @jesse_wotring in his most recent publication: validating lactoferrin’s anti-SARS-CoV-2 activity!
journalofdairyscience.org/ar…
jonnysexton retweeted
A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction biorxiv.org/cgi/content/shor… #bioRxiv
jonnysexton retweeted
This project was not possible without the hard work and collaboration between @Charles_J_Zhang @momeara @CapelingMeghan @DayFerrerTorres @TheSpenceLab @RobertFontanaMD @jonnysexton and others – at Ann Arbor, MI
jonnysexton retweeted
We are happy to announce our SARS-CoV-2 drug repurposing screen has just been published in PNAS! This was a massive team effort that would not be possible without many, including @ChristianeWobus @TheSpenceLab @ArulChinnaiyan @momeara
pnas.org/content/118/36/e210… – at Ann Arbor, MI
Our Covid19 drug repurposing screen found 15 FDA-approved drugs and the dietary supplement Lactoferrin have strong antiviral effects in vitro: biorxiv.org/content/10.1101/…
ShoutOut to UM Center for Drug Repurposing in Scientific American's new article on drug repurposing: scientificamerican.com/artic…
Check out our collaborative study with Dr. Rishel Vohnoutka where we used @CellProfiler to quantitate cytoskeletal structure using radial distribution of intensities! On cover of MBoC - molbiolcell.org/doi/10.1091/…
jonnysexton retweeted
Brand new #machinelearning cheat sheet is now available for download at bit.ly/34PLT6i
#KNIME #datascience
jonnysexton retweeted
@jonnysexton introducing the new MICHR Drug Repurposing center, designed to find new usage in old drugs! umdrugrepurposing.org
jonnysexton retweeted
Super big credit goes to @bioformats for all their file readers.
Microscope companies: KNOCK IT OFF with the proprietary formats already! You are a drag on scientific progress.
jonnysexton retweeted
We will be hosting a hands on high content analysis workshop in Utrecht this July! No prior experience is necessary. Check out the link below for details.
utrecht_hca_bootcamp.eventbr…