Kelly Sullivan (@kellydsullivan) header
Kelly Sullivan (@kellydsullivan) profile picture

Kelly Sullivan

@kellydsullivan

Interested in altered signaling of Down syndrome. Emphasis on IFN and immune dysregulation. @CrnicInstititue | @CUAnschutz | @CUDevBio @CSD_CUAMC | @CUHMGGP

 Aurora, Colorado
Joined October 2017
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  • Followers239
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Photo by Kelly Sullivan (@kellydsullivan)Photo by Kelly Sullivan (@kellydsullivan)
🧬 New research, insights & hope from GLOBAL's Affiliate, @CrnicInstitute published in the high-impact journal @Nature reveals a major step toward more personalized care & targeted treatments for people with #DownSyndrome ➡️ bit.ly/4fC5D3m
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
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Join the Linda Crnic Institute for Down Syndrome for our annual Down Syndrome Research Symposium! Dr. Ukpong Eyo will present "Glial-glial interaction regulate excitatory synapse development." Register today at bit.ly/DS-Symposium.
Graphic image with a headshot of Dr. Ukpong Eyo and the Crnic Institute logo. Text reads as follows: "Meet the speaker. Crnic Institute Down Syndrome Research Symposium. Glial-glial interaction regulate excitatory synapse development. 16 September 2026. Ukpong Eyo, PhD. University of Virginia.

ALT Graphic image with a headshot of Dr. Ukpong Eyo and the Crnic Institute logo. Text reads as follows: "Meet the speaker. Crnic Institute Down Syndrome Research Symposium. Glial-glial interaction regulate excitatory synapse development. 16 September 2026. Ukpong Eyo, PhD. University of Virginia.

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Fantastic news!
Global Down Syndrome Foundation (@GDSFoundation) profile pictureGlobal Down Syndrome Foundation@GDSFoundationAug 6
🎉 HISTORIC SENATE VICTORY! The DeOndra Dixon #INCLUDEProjectAct passed unanimously—bringing the first NIH-wide #DownSyndromeResearch program closer to law. Huge thanks to Senators @SenatorHick & @JerryMoran for leading the charge!💙💛 Learn more: bit.ly/3ArbCao
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
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🎉HISTORIC NEWS! The House unanimously passed the #DeOndraDixon INCLUDE Project Act, named in memory of @JamieFoxx’s sister & #GLOBALAmbassador DeOndra Dixon. Next? The Senate! Watch @RepDianaDeGette, @RepGuthrie, and @RepPaulTonko live floor remarks! bit.ly/4pEgXAE
Image from Global Down Syndrome Foundation (@GDSFoundation)
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Now out in Blood @ASH_hematology @BloodPortfolio ashpublications.org/blood/ar… Really proud of this one, and grateful to the reviewers for the constructive criticism. It really is a much better paper now!
The red blood cell proteome and interactome identify a Band 3–BLVRB axis regulating hypoxic...

The red blood cell proteome and interactome identify a Band 3–BLVRB axis regulating hypoxic...

Key PointsDeep proteomics defines a complete, contamination-free RBC proteome (3775 proteins) and O2-dependent interactome by cross-linking proteomics.The

ashpublications.org
Angelo D'Alessandro (@dalessandrolab) profile pictureAngelo D'Alessandro@dalessandrolabMar 7
Red blood cells make up 83% of the cells in the human body. Mature RBCs lack nuclei (no gene expression) and organelles, and >90% of their dry weight is hemoglobin. Yet we have lacked a clean, contamination-free map of their proteome. Until now. biorxiv.org/content/10.1101/…
Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic...

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic...

Red blood cells (RBCs) have long been regarded as passive oxygen carriers, yet growing evidence reveals a complex, dynamic proteome independent of de novo gene expression. Here, we define the...

biorxiv.org
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Registration is open for the 2026 National Down Syndrome Congress Convention, taking place July 23-26, 2026, in Orlando, FL! Register at bit.ly/4bh9T6e, and be sure to select “Yes” for email consent from the Crnic Institute for research participation information.
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
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Trisomy 21 alters ciliary localization of Sonic Hedgehog signaling proteins biorxiv.org/content/10.64898…
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📣 Closing out our time on the Hill advocating for the DeOndra Dixon INCLUDE Project Act — and the impact was undeniable! 87 meetings. 2 days. 1 powerful message.🥳 🏛️
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
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🚨 Seeking participants without Down syndrome! The Human Trisome Project is currently recruiting people without Down syndrome in the following age ranges: Male: 17-22 years old Compensation is provided. Contact [email protected] to make your appointment today.
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
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Kelly Sullivan retweeted
Cell Reports (@CellReports) profile picture
Cell Reports@CellReportsJan 23
Altered hepatic metabolism in Down syndrome dlvr.it/TQWZl2

Altered hepatic metabolism in Down syndrome

Dunn et al. show that individuals with Down syndrome display widespread evidence of altered hepatic function in the plasma proteome and metabolome, typified by elevated plasma bile acids. Using a...

cell.com
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‼️📰 Hot Off the Press: A new @CrnicInstitute discovery published in the renowned science journal @CellReports reveals liver dysfunction in #Downsyndrome & suggests diet can make a big difference: bit.ly/4bO4QMj 🥗
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
Image from Global Down Syndrome Foundation (@GDSFoundation)
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A new Crnic Institute study reveals people with Down syndrome show consistent signs of liver dysfunction across the lifespan. With support from @GDSFoundation, this research offers hope for simple, actionable interventions to support better health. bit.ly/4jQOLHD.
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
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Excited to share this work. A huge effort from many team members, led by former @CUHMGGP PhD student and current @CrnicInstitute Post-doc, Dr. Lauren Dunn! Altered hepatic metabolism in Down syndrome: Cell Reports cell.com/cell-reports/fullte…
Altered hepatic metabolism in Down syndrome

Altered hepatic metabolism in Down syndrome

Dunn et al. show that individuals with Down syndrome display widespread evidence of altered hepatic function in the plasma proteome and metabolome, typified by elevated plasma bile acids. Using a...

cell.com
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Kelly Sullivan retweeted
Bruna (@brunazampieri) profile picture
Bruna@brunazampieriJan 14
Paper out! Reanalysis of snRNA-seq data from #Downsyndrome postmortem cortex (<36y), integrated with DS-iPSC-derived astrocytes, reveals dysregulated complement signaling and altered astrocyte function in DS Thanks to co-authors, FAPESP, and the families! link.springer.com/article/10…

Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmo...

Acta Neuropathologica Communications - Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is...

link.springer.com
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Kelly Sullivan retweeted
Anirban Maitra (@Aiims1742) profile picture
Anirban Maitra@Aiims1742Jan 11
Really important tool @AnnaMolofskyLab @Molofsky_lab to study interferon response in vivo! The IFN-brite (Bright Reporter of Interferon sTimulated gene Expression) 🐁: A genetically encoded reporter reveals interferon responses in multiple cell lineages biorxiv.org/content/10.64898…
Image from Anirban Maitra (@Aiims1742)
Image from Anirban Maitra (@Aiims1742)
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#CUAnschutz was ranked No. 5 globally for research hospitals in health sciences, according to @Nature. Home to two nationally ranked hospitals, @uchealth University of Colorado Hospital and @ChildrensColo, our faculty is shaping the future of healthcare.
Image from University of Colorado Anschutz (@CUAnschutz)
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The call for poster abstracts for the 6th International Conference of the Trisomy 21 Research Society is now open! Conference registration for the conference, to be held June 17-20 2026 in Denver, CO, USA, is open as well. t21rs2026.com/call-for-poste…
Call for Poster Abstract - T21RS 2026

Call for Poster Abstract - T21RS 2026

T21RS 2026. 6th International Conference. Insights from Across the Lifespan. Denver, CO. June, 2026.

t21rs2026.com
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Congrats!
Arjun Krishnan (@compbiologist) profile pictureArjun Krishnan@compbiologistJan 5
Our perspective is now out in @naturemethods! Congratulations again to @yhbioinfo & the rest of the team! nature.com/articles/s41592-0…
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Happy Holidays from the Crnic Institute! This year, our team was happy to gather in community for a festive cookie exchange. We wish you warmth, joy and prosperity this holiday season.
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
Image from Linda Crnic Institute for Down Syndrome (@CrnicInstitute)
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Molishree Joshi, PhD, and Kimberly Jordan, PhD, leaders of two CU Cancer Center shared resources, have received the first-ever National Cancer Institute (@theNCI) R50s for core-based scientists at @CUAnschutz! 👏 Learn more: news.cuanschutz.edu/cancer-c…
Photos of Molishree Joshi and Kimberly Jordan in two bubbles surrounded by CU branded circles.

ALT Photos of Molishree Joshi and Kimberly Jordan in two bubbles surrounded by CU branded circles.

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