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Joined March 2025
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We have a moral obligation to install advanced molecular sensors in all the toilets of the world.
That is all.
Hey @BenAffleck dude I need half an hour to persuade you that we must build utility-scale solid-state molecular sensing and it will be the most important conversation you ever have about science.
here i go one more time... we must build utility-scale solid-state molecular sensing
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Molecular_Streamer retweeted
Perhaps today is a funny day to point out that JD Vance’s first job post lawyer-era was working for Deisseroth’s optogenetics startup
e.g., solid-state utility-scale molecular sensing in the first 100M homes
Molecular_Streamer retweeted
I hate it when people say there’s no such thing as a bad trip but I have to admit the worst LSD trip I had was in hindsight one of the best. during my nomad years, I was invited to help run a hackathon in the forest in middle of nowhere Sweden. brilliant event, 50% nerds and 50% hot people. on the last day someone proposed we trip together to cap it off. I thought YOLO, why not. but then the next suggestion was that we go hiking off into the mountains... to a rock formation called the Troll Church... where the Vikings used to make human sacrifices... I had my misgivings but not wanting to be a spoilsport I went along with the herd. now as you can guess, the LSD was a much bigger dose than I anticipated, I was extremely super high, and finding myself in a historic location charged with weird pagan energies was rather overwhelming. I felt like that scene in Inception when the horizon suddenly lifts up overhead and I am being rolled under the bedrock like being tumbled by big surf, I am smeared out, crushed by geological time and glaciers and ice ages, pulverised until there was nothing left of me not even lichen or moss and the old trolly spirits of the mountain had their way with me. in brief: anguish and terror. now by this stage I had been on the road for a few years, travelling from place to place with my dear wife, and the old gods told me my karmic balance was waaaaaay out of whack, because everywhere I go, from a friend’s couch to a hotel or airbnb, I’m always a guest, and the ancient right of hospitality is not just a privilege it’s also a responsibility, you have to give more than you take. I felt confronted with the spiritual debt I had been racking up these past few years. anyway I admitted to my friends that I am in no shape to move, I am incapacitated, I have become a liability to the hiking party, and I will need physical assistance to make it back to the cabin. thankfully two giant Scandinavian men, one icelander and one dane, picked me up bodily, hugged the warmth back into me, and took turns to lift me like a sack of potatoes back home. over the next few hours as I sobered up I made sense of the whole distressing enterprise and concluded that starting immediately, I needed to stop being a guest and start being a host. I need to balance the ledger. from that day I decided I would only live in a house with a guest room. that was nearly a decade ago. now I live in a 6000 sqft house with 10 guest rooms and hospitality is my only spiritual practice and indeed in this house we cast magic spells of healing and protection on a regular basis. in retrospect what a surprising way to discover your mission in life. and incidentally what a lovely way to discover true intimacy with men. in conclusion, acid sucks, everyone should do it.
Biology is Just Beginning.
I used to work with this schizophrenic guy from the deep south (Lousiana Bayou) who was deadly allergic to bee stings.
A bee stung him while he was landscaping, and his first reaction was to run to a convenience store and buy a pouch of Red Man chewing tobacco, which he swallowed entirely.
He said to himself "do like you got bit by a snake" and prevented himself from going into shock.
By the time the EMTs arrived, he was totally fine. They were flabbergasted. He drank a caffeinated malt liquor and went back to work.
Very high-priority reason why we must build utility-scale molecular sensing. #superbiology
Introducing: continuous variational synthesis
📄 jurabio.com/s/cvs.pdf
We’re pleased to announce a new advance in our ability to synthesize generative model-designed DNA sequences at petascale.
Molecular_Streamer retweeted
Alphafold and similar models neglect the quantum van der Waals couplings of aromatic rings of tryptophan, phenylalanine snd tyrosine in protein folding. They are weak but numerous and act collectively. What difference does it make? Roughly speaking. It’s the same difference as between a computer and a conscious brain.
Anthropic ran a model against every ribosome structure ever deposited and found 240 of them fold in a way no force field allows.
Nobody asked it to check the models. It was asked which deposited atoms are doing something the physics does not permit.
> PULL - every deposited structure, coordinates only, no papers attached
> STRAIN - each bond angle and contact scored against what chemistry permits
> WARN - flags atoms held in place by the fitting software, not by the data
> TRACE - follows the flagged atom back to the resolution it was solved at
> MAP - checks whether the density under that atom ever supported it
> WEIGHT - ranks flags by how much downstream work relies on that region
Most flags were harmless. Low resolution means the model is a best guess, and everyone in the field already treats it that way.
The dangerous pile was the opposite. 240 flags sat in structures published as high resolution, in the regions people quote.
Eleven of those regions are where drug binding gets argued, which means the argument rests on atoms that were placed by software.
A structure is not a photograph. It is a model fitted to a blurry map, and the fit carries opinions the coordinates never show.
The field checks structures against each other and against the map. Almost nobody checks them against what a bond can physically do.
Re-solving one structure takes a postdoc a month. This scored the whole archive in a weekend against data that was already public.
How it's wired is in the article below.
Things we get to have with utility-scale molecular sensing.
This is fun.
1. Mango Banana - banana on the outside, mango on the inside. Enough said.
2. Plant machine interfaces - we should be able to trade plants N,P,H2O for reduced carbon compounds. Do to them what they did to chloroplasts
3. Solution phase self assembly of 3D memory chips using designed self-assembly of macromolecules - do we really get protein design
4. A brain the size of a building. - what would it be thinking?
5. A five assed monkey - bc South Park
6. Self growing housing - the rent is too damn high
7. Obviously brain machine interfaces - I will judge this by when I can browse the web by thinking about it.
8. Dinosaurs.
9. Cats with dog personalities.
10. A nice smelling microbiome
Molecular_Streamer retweeted
Someone needs to make a version of Don't Look Up, but for AI, with the first half leading up to the present day, with clips taken from what's actually happened in real life.
Molecular_Streamer retweeted
Effective Will Hunting
Sean: I thought about what you said to me the other day, about saving humanity. Stayed up half the night thinking about it. Something occurred to me and I fell into a deep, peaceful sleep and haven’t thought about you since. You know what occurred to me?
Will: No.
Sean: You’re just a kid. You don’t have the faintest idea what you’re talking about.
Will: Why, thank you.
Sean: It’s all right. You’ve never been out of the LessWrong forums.
Will: Nope.
Sean: So if I asked you about ethics, you’d probably give me the skinny on every philosophy book ever written… Peter Singer? (Beat.) You know a lot about him. Moral obligations, drowning children, the whole works, right? But I bet you can’t tell me what it feels like to have somebody depend on you. Actually depend on you. When you’re tired. When you’re angry. When keeping your word means giving up something you’re never gonna get back.
If I asked you about humanity, you’d probably give me a number. You may have even worked out how much a life is worth. But you couldn’t tell me what it feels like to sit beside someone you love and hear a doctor say there’s nothing more they can do. To look at her… and realize the whole world’s still gonna be here tomorrow. Just going about its business.
You’re a smart kid. I ask you about power, and you’d probably—uh—throw an alignment paper at me, right? Incentives. Oversight. All the safeguards. But have you ever watched a good man discover how much he likes being obeyed? Watched him bend a rule, just once, because the work’s too important? Then another. Then another. Still a good man. Still saving the world. Just needs everybody to do what he says.
And if I asked you about love, you’d probably tell me how much you care about future generations. All those people. All those centuries. But have you ever loved somebody whose choices you couldn’t understand? Known they were making a mistake… and known their life belonged to them? You couldn’t argue them out of it. Couldn’t make the decision for them. You had to stay. Had to love them through the part you couldn’t fix.
You talk about caring for humanity. Humanity’s gonna disappoint you, Will. It’s gonna hear your beautiful argument and go right on wanting something else. You gonna care about it then? When it laughs at you? When it tells you to leave it alone?
(Will looks away.)
But you’re a genius, Will. No one denies that. No one could possibly understand the depths of you. And you presume to know what everybody ought to want because you’ve built a model of their happiness.
You’re an effective altruist, right?
(Will nods.)
Do you think you’d know the first thing about a woman’s life—what she’s lost, what she hopes for, what she’d die for—because you put a number on her welfare? Does that encapsulate her?
Personally, I’d like to hear about you. Why you need to be the one holding the future. What you’re afraid will happen if the rest of us get a say. Because I’m fascinated. I’m in.
But you don’t wanna talk about that, do you, sport?
You’re terrified of what you might say.
Your move, chief.
(Sean stands and walks away.)





















