Postdoc @EvanWeberPhD @ChildrensPhila | Fellow @CancerResearch | Fellow @IDEAL_Research | #CART | #SingleCell |#InclusiveTeaching | She/Her 🏳️🌈
Philadelphia, PA
Joined November 2019
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I'm wildly proud to share our FIRST Weber Lab paper, out today in @Nature! I want to share a story about how this whirlwind of a project came together. A 🧵 on teamwork, open science, and how far we can go when we intentionally build a culture of trust in research. 1/
Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?
We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen. 1/
nature.com/articles/s41586-0…
Kat Mueller, PhD retweeted
Our new, comprehensive review on CAR T cell persistence is officially published in @CellCellPress @trendscancer. Fantastic work from lead authors @kpmueller1 @JGrenierMDPhD.
Link to the full article:
cell.com/trends/cancer/fullt…
Kat Mueller, PhD retweeted
Congratulations! So well deserved!!
BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
Durable CAR T persistence is among the great unsolved challenges within our field. But what do we actually mean when we say a CAR T cell is "persistent"? @JGrenierMDPhD, @EvanWeberPhD and I attempt to answer this question in our new review @trendscancer. 1/
Finally, we propose a unifying framework to define the concept of CAR T "persistence". We argue that the underlying mechanisms likely differ between active tumor killing vs. long-term immunosurveillance; we refer to this as "type I" and "type II" persistence, respectively. 5/
Thrilled to see this work out - congratulations to Dan Pham on a beautiful paper!
Congratulations to Dan Pham for her paper published today! Dan showed that autofluorescence lifetime imaging can monitor single cell metabolism to improve CAR T cell metabolic fitness. @sahakris @UWCarbone @Morgridge_Inst @UWMadEngr
rdcu.be/eGExD
nature.com/articles/s41551-0…
This is terrifying, heartbreaking, infuriating.
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at @Columbia & academic career... 1/🧵
Thanks for the shout out, Evan! I'm so honored to work with @CancerResearch, and psyched to get started on these experiments!
Congrats to our talented postdoc @kpmueller1 on receiving this prestigious and competitive @CancerResearch award! Big things to come!
Kat Mueller, PhD retweeted
Patient-derived glioblastoma organoids as real-time avatars for assess... sciencedirect.com/science/ar…
Happy to report our work using #GBM organoids to predict #CART response in #glioblastoma @PennCancer
Kat Mueller, PhD retweeted
Excited to share our latest work in @NatureCancer to get a better understanding why relapsed T-ALL is so deadly and potential target strategies, led by Jason Xu and @changya1 with members of David Teachey, @junjyang, @CMullighan and many great colleagues. twtr.to/foS9o.
Kat Mueller, PhD retweeted
If only we had data on vaccine efficacy
IF ONLY WE HAD THE DATA
#vaccineswork
Kat Mueller, PhD retweeted
In this new Review, Caroline Diorio, David Teachey & Stephan Grupp discuss the progress made and remaining roadblocks with allogeneic CAR cell therapies for cancer: nature.com/articles/s41571-0…
I'm honored to share that I have been awarded an Irvington Postdoctoral Fellowship from @CancerResearch! This funding will support my ongoing CAR T cell therapy research with @EvanWeberPhD at @ChildrensPhila. 1/
I am deeply grateful for my colleagues and mentors who supported me through many iterations of this proposal. Huge thanks in particular to Suzi McClory, Alice Wang, @CarolineDiorio, @GruppSteve, and @KaiTanLab1, all incredible collaborators who have taught me so much. 2/
And of course, I am beyond thankful for my friends in the Weber Lab, and for our fearless leader @EvanWeberPhD. I am the luckiest postdoc in the world to work with such brilliant, generous and kind scientists. You inspire me every day! 3/3
Kat Mueller, PhD retweeted
Spend some time in this thread. We need systemic change in public education now, & it's but a part of the problem of racism & misogyny.
👇🏽
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