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Engel Lab

@lab_engel

Impressum: https://nitter.cf/t.co/3d9yxt81az

 Regensburg, Germany
uni-regensburg.de/biologie-vorklinische-medizin/strukturelle-biochemie
Joined June 2018
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More good news: As of this month, the group and my position are formally tenured! Many thanks to everyone who made this possible, first and foremost the amazing Structural Biochemistry Team
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Also, a giant thank you to mentors and collaborators @mpgpresident @BangeBalcony @VanniniLab @DinaGrohmann @CarrieBernecky @Geyer_lab and many more on and off twitter
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Many congratulations to Julia for finishing her PhD with summa cum laude!
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I never imagined that there would be a paper from my lab titled "The structural basis of ..." but first author @2Magdalena1 and the very collaborative archaeal RNA polymerase made it work 😀. Read it here: academic.oup.com/nar/article…. Thank you also to our partners @lab_engel 🤝!
Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment

Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment

Abstract. Archaeal transcription is carried out by a multi-subunit RNA polymerase (RNAP) that is highly homologous in structure and function to eukaryotic

academic.oup.com
Dina Grohmann (@DinaGrohmann) profile pictureDina Grohmann@DinaGrohmann9 Jan 2024
Happy new year and happy new pre-print biorxiv.org/content/10.1101/… with cryo-EM structures of the archaeal RNA polymerase in its apo state and during elongation w/ and w/o Spt4/5 featuring some distinct archaeal features. #Archaea #cryoEM #transcription Some key findings 🧵
Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment

Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment

Archaeal transcription is carried out by a multi-subunit RNA polymerase (RNAP) that is highly homologous in structure and function to eukaryotic RNAP II. Among the set of basal transcription factors,...

biorxiv.org
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Many thanks to Ruchi Anand @ruchianand1975 for inviting Michael and Christoph to speak at the inauguration symposium of the #cryoEM facility at @iitbombay Congratulations to an incredible event and all the best for the facility in a flourishing structural biology community
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And many congratulations to --> DOKTOR Philipp Becker <--
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Many congratulations to --> DOKTOR Florian Heiß <--
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Structural basis of transcription elongation and effects of Spt4/5 engagement in archaea. Preprint in collaboration with our neighbors of the Grohmann Lab @DinaGrohmann combining the strength of single-molecule analyses and single-particle #cryoEM biorxiv.org/content/10.1101/…
Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment

Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment

Archaeal transcription is carried out by a multi-subunit RNA polymerase (RNAP) that is highly homologous in structure and function to eukaryotic RNAP II. Among the set of basal transcription factors,...

biorxiv.org
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Again, iterative screening of the optimal conditions for bottom-up assembled transcription complexes as outlined by Michael Pilsl was instrumental link.springer.com/protocol/1…

Preparation of RNA Polymerase Complexes for Their Analysis by Single-P

Recent technological progress revealed new prospects of high-resolution structure determinationStructure determination of macromolecular complexes using cryo-electron microscopy (cryo-EM)Cryo-elect...

link.springer.com
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The manuscript includes four single-particle reconstructions from our inhouse CryoARM200 setup, congratulations to first author Daniela Tarau and the entire team.
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Some news from the lab with a bit of delay: Holiday-party of the lab brings the team to creative three-dimensional miniature golf. Apparently, the PI has no feeling for 3D structures: Christoph lost…
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Our Michael was awarded the PhD prize of the Faculty on the Day of Biosciences @uni_regensburg Many congratulations!
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Many congratulations @CramerLab and @NogalesLab
The Shaw Prize (@ShawPrize) profile pictureThe Shaw Prize@ShawPrize30 May 2023
The #ShawPrize in #LifeScienceAndMedicine 2023 is awarded in equal shares to Patrick Cramer and Eva Nogales for pioneering structural biology that enabled visualization, at the level of individual atoms, of the protein machines responsible for #genetranscription. #ShawPrize2023
Image from The Shaw Prize (@ShawPrize)
Image from The Shaw Prize (@ShawPrize)
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New review from the Kobayashi lab @Tako_bio by @HoriYutaro et al. I am glad we could contribute, thank you for the invitation!
Nature Reviews Molecular Cell Biology (@NatRevMCB) profile pictureNature Reviews Molecular Cell Biology@NatRevMCB2 Feb 2023
Now Online Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes dlvr.it/ShqZrY
Image from Nature Reviews Molecular Cell Biology (@NatRevMCB)
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Hard to believe that it is already five years... Celebrating our lab-anniversary and welcoming our new team member Matthias Breindl
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Impressions from the public outreach event „Long night of Science“ (Nacht.Schafft.Wissen) Happy we could contribute and many thanks to all organizers and participants for a great event with lively discussions @uni_regensburg uni-regensburg.de/veranstalt…
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1/2 Presenting the 2022 class of our PhD course 'Single particle #cryoEM of macromolecular complexes' @uni_regensburg Congratulations to all participants after an exciting week and thanks to the RNA Biology section of @RigelSchool and to our sponsors @Cytiva and @thermosci
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2/2 Many thanks to everyone how supported us, especially the international team of trainers: Bettina Böttcher @BoettcherCryoEM – Christine Ziegler – Arjen Jakobi @CryoTUD - Tom Burnely @ccp_em – Tristan Cragnolini – Alexandre Durand @DurandA17996106 – Grigory Sharov @GSharov_
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3 days to register!
Kurt Schmoller (@SchmollerLab) profile pictureKurt Schmoller@SchmollerLab8 Sep 2022
One week left to register and apply for a talk at the #MunichYeastMeeting 2022 @HelmholtzMunich October 10th helmholtz-munich.de/munich-y… @ThePughLab @SophieMartinLab @lab_engel @Dey_Gautam #MYM2022
Image from Kurt Schmoller (@SchmollerLab)
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Our structural and functional investigation of human RNA polymerase I now out @LSAjournal The study includes #cryoEM data from our inhouse #cryoARM @uni_regensburg CRISPR/Cas9 genome editing, confocal microscopy, functional biochemistry and phylogenetics life-science-alliance.org/co…

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans

Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we present the purification...

life-science-alliance.org
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Third first-author paper by PhD student Julia Daiß in three years: Many congratulations! Also thank you for many contributions from our fabulous collaborator teams Tom Moss @VanniniLab Konstantin Panov @CarrieBernecky and Till Rudack See related work by the Xu and Müller labs
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