Lori Passmore (@lapassmore) profile picture

Lori Passmore

@lapassmore

Molecular biologist. Group Leader @MRC_LMB. Fellow @clarehall_cam. Optimist. (she/her) Views/opinions are my own.

 Cambridge UK
www2.mrc-lmb.cam.ac.uk/groups/passmore/
Joined January 2015
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Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)Photo by Lori Passmore (@lapassmore)
I am no longer actively using this account. Please find me on the other place. 🦋
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We have an open #postdoc position to study the molecular mechanisms of #DNArepair !🧬🔬 The project will build on recent findings nature.com/articles/s41586-0… and established collaborations, using #cryoEM and #SingleMolecule imaging. Access to fantastic facilities @MRC_LMB .
FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions

FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions

Nature - FANCD2–FANCI is a sliding clamp that diffuses on double-stranded DNA but stalls when it reaches a single-stranded gap, providing a unified molecular mechanism that reconciles the...

nature.com
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Come join the amazing members of my team 🤩🤩!
Image from Lori Passmore (@lapassmore)
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Lori Passmore retweeted
Pilar Cossio (@PilarCossio2) profile picture
Pilar Cossio@PilarCossio223 Oct 2024
CryoEM community: we encourage you to submit applications to the Almeida Award #cryoEM BPS subgroup:
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I presented this work at #EESRNA @embl @EMBLHeidelberg An amazing meeting organised by @LabConti @OlivierDuss @torbenheick and Karla Neugebauer!!
Lori Passmore (@lapassmore) profile pictureLori Passmore@lapassmore20 Oct 2024
New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
Image from Lori Passmore (@lapassmore)
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Unfortunately I had to leave the conference very suddenly and unexpectedly due to a family emergency. I really missed meeting and speaking with so many people. Many apologies - I would be happy to zoom meet with anyone who wants to chat - please drop me an email!
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New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research
Image from Lori Passmore (@lapassmore)
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The enzymatic machineries of gene expression (deadenylation complexes, RNA polymerases) are highly conserved. .... but the evolutionary plasticity of IDRs found in a multitude of regulators (RNA adaptors, transcription factors) allows rewiring of gene expression programs. 10/
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Preprint here: biorxiv.org/cgi/content/shor…
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Great fun with the @RappsilberLab ! Photo-crosslinking improves the contrast of crosslinking mass spectrometry.
Francis O'Reilly (@FJ_OReilly) profile pictureFrancis O'Reilly@FJ_OReilly11 Sep 2024
New preprint! We show that photo-crosslinking dramatically improves structural insights into protein complexes compared to traditional crosslinking MS methods. biorxiv.org/content/10.1101/…
Molecular insights into dynamic protein structures by high-contrast crosslinking mass spectrometry

Molecular insights into dynamic protein structures by high-contrast crosslinking mass spectrometry

Proteins are comprised of structured domains and dynamic regions, and both are essential for biological function. However, studying dynamic regions is challenging using most structural biology...

biorxiv.org
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Very cool structure!
conti_lab (@LabConti) profile pictureconti_lab@LabConti10 Oct 2024
Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem 👇👇👇
Image from conti_lab (@LabConti)
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I am really looking foward to working with @SjorsScheres as Joint Head of Structural Studies @MRC_LMB !
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