#research and #fundraising platform combining Dynamic Review & #PrecisionFunding to make #med research efficient, inclusive & impactful. #BetterMedicineTogether
Calgary, AB
Joined January 2022
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Check out our latest blog post on the science behind autism by @UBC med student Florence Kalia!
Also check out Florence’s recent article on ADHD - a condition we have all heard about but often misunderstand! letsgetproof.com/blog/unders…
Also check out Florence’s recent blog on understanding ADHD here: letsgetproof.com/blog/unders…
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It's Trainee Spotlight Tuesday 🔦 Read on and learn about @rahulnair320 's work!
#trainees #vci #vascularcognitiveimpairment #research #brainhealth
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It's Trainee Spotlight Tuesday 🔦 Read on and learn about Dima's work!
#trainees #vci #vascularcognitiveimpairment #research #brainhealth
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Day 2 of #WSC2026 is underway!
It was lovely to speak with @draravindganesh, who shared his insights on ethnic variations in carotid artery characteristics and plaque features, the COSMOS scale for ranking stroke outcomes, and how stroke outcome measurement is changing.🧠
Full interview coming soon to VJNeurology.com🎥
@WorldStrokeOrg
#StrokeResearch #StrokeCare #WorldStrokeCongress
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This Special Report by @nishita_singh3 et al. outlines key considerations in the design and interpretation of clinical trials performed in the prehospital setting. #stroke ahajrnls.org/4i7Lfby
@philip_bath @mihill68 @cheryl_carcel @draravindganesh @MDStebnerAl @mayank_G0
ALT Graphic abstract in Singh et al.
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💬 Editorial by Eric E. Smith, MD, MPH, and Aravind Ganesh, MD, DPhil: In patients with asymptomatic #carotid artery stenosis, carotid revascularization did not improve cognition or prevent cognitive decline compared with medical therapy alone in the CREST-2 cognitive analyses.
The findings indicate that clinicians should not counsel patients that cognition will improve after revascularization and should instead focus discussions on stroke prevention.
ja.ma/4BpfVxX
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📊📚Systematic review & meta-analysis suggests remote ischemic conditioning may improve functional and neurological outcomes after acute ischemic stroke
Read more here!👇
journals.sagepub.com/doi/ful…
@kadenlam8 @WilliamBetzner @draravindganesh
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🧠 To close out #WorldStrokeDay, we bring to you an exclusive podcast exploring this year's theme: Every M1nute Counts. ⏱️
🩺 From reperfusion therapies to AI in stroke diagnosis and treatment, with interviews from #WSC2026.
🎧 Listen: ow.ly/eBcP51023K4
🎙️ Featuring @GeoffreyDonnan, @ProfSteveDavis, @draravindganesh and Jing Zhao.
@WorldStrokeOrg @TheStrokeAssoc #Stroke #ActFAST
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🚨 TRIC-VCI - our pilot phase 2b trial of RIC in vascular cognitive impairment - is now out @alzdemjournals. Both twice & once daily RIC were safe & well tolerated. TNF-alpha and IL-1b levels declined over treatment, representing treatment-related markers doi.org/10.1002/trc2.70335
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Interesting results in @JAMA_current from CREST2 and CREST-H studies indicating that revascularization of asymptomatic carotid stenosis does not improve cognitive outcomes. Here is our accompanying editorial @VCI_EricSmith: jamanetwork.com/journals/jam… @DCNSNeuro @HotchkissBrain
🧵 In patients with severe asymptomatic #carotid artery stenosis, carotid revascularization with carotid artery stenting or carotid endarterectomy plus intensive medical management did not improve cognition vs intensive medical management alone over up to 4 years.
These findings indicate that cognitive benefit should not be presented as an expected outcome when discussing treatment options for this population.
ja.ma/4xwkzH9
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🚨 To improve the clinical relevance and completion of cognitive outcomes in studies of stroke, aging and cardiovascular diseases, we propose a new multidimensional and inclusive framework, Major Adverse Cognitive Events (MACE-Cog)! @DrRickSwartz ahajournals.org/doi/10.1161/… @CircAHA
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Futility trials seem feasible in Alzheimer disease-associated dementia, offering a faster, cost-effective alternative to traditional phase 2 randomized-controlled trials: hubs.la/Q04mSDFq0
We are glad to have supported this important work on stroke care for people with disability/dementia by @draravindganesh and team!
🚨In this intl mixed-methods study led by postdoc Bogna Drozdowska, we found physicians encounter multifaceted uncertainty in determining Goals of Care for ppl with disability or dementia, which may contribute to adverse variability in stroke care @WilliamBetzner @RamkumarRaksha
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🚨Brain frailty is associated with worse outcomes after EVT for stroke. Here, we examine sex differences in the assoc of brain frailty with stroke outcomes in the ESCAPE-NA1 trial: sciencedirect.com/science/ar… @joachimfladt @mihill68 @mayank_G0 @DCNSNeuro @HotchkissBrain @OBrien_IPH
ALT Forest plots showing the association of brain frailty markers and sex with mRS 0–2 at 90 days. mRS, modified Rankin Scale; OR, odds ratio; CI, confidence interval; CC/IT, intercaudate distance to inner table width.
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🚨In this intl mixed-methods study led by postdoc Bogna Drozdowska, we found physicians encounter multifaceted uncertainty in determining Goals of Care for ppl with disability or dementia, which may contribute to adverse variability in stroke care @WilliamBetzner @RamkumarRaksha
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In a mixed method study, the investigators found that physicians encounter profound, multifaceted uncertainty in determining goals of care for patients with disability or dementia after #stroke. ahajrnls.org/4oIqUfE
ALT Graphic abstract in Drozdowska et al.
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🚨Cerebrovascular fibromuscular dysplasia (cFMD) is sometimes seen in patients with stroke/TIA - implications for future risk are unclear. In this cohort study, we found that cFMD was rare but assoc with substantial rates of recurrent stroke & mortality: strokejournal.org/article/S1…
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🚨The cost & complexity of phase 2 RCTs hinder development of promising AD treatments. We show that futility trials seem feasible in AD dementia, offering a faster cost-effective alternative to traditional ph2 RCTs. CDR-SB may be an optimal primary outcome neurology.org/doi/10.1212/WN…
