@lisawehden

people person @plymouthstreet 🌊

SF
Joined January 2012
incredible team and execution - let's go @carthymctom @akilian and @justinglibert!
In 12 weeks, we built a research facility that is run entirely by AI. AI designs, executes, and observes experiments end-to-end across biology, chemistry, and materials science. We’re introducing SciUniverse: a benchmark that measures AI’s ability to do real-world scientific research.
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Lisa retweeted
> be me > @akilian says ai obvs going to do big science > ok then it will need a lab right > actually it will need REALLY big labs > they don’t exist > ok we will build it > mfw ai doing science with the homies
In 12 weeks, we built a research facility that is run entirely by AI. AI designs, executes, and observes experiments end-to-end across biology, chemistry, and materials science. We’re introducing SciUniverse: a benchmark that measures AI’s ability to do real-world scientific research.
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Great read by @lisawehden lisawehden.substack.com/p/we… The reason I love work from @GoogleDeepMind , or friends taking long term bets is at the very least has a reason behind and why they are doing what they are doing!
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Interact: the secret home to some of the most talented, sincere, wide-ranging, and influential people in tech. So thankful to have made the cut back in 2018!
let me be more specific because Interact is elusive to many Interact members have founded: Etched, Graphite, Figma, Cognition, Figma, Scale, Socket, Modal Also some of the best operators. Start asking around and you'll see for yourself... they're everywhere!
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Rune & Rajiv are extraordinary founders. Deploying AI safely and securely is good for business. At AIUC, they’ve built a third-party audit and certification layer for AI agents. It’s going to be massive. Lucky to be a small investor - talented folks, they are hiring! Check out roles at aiuc.com/
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“Most generations inherit their world. Some must build it anew.” Massive congrats to @Brendan_McCord and @_mattmandel for launching @cosmos_vc, a $77.6M fund to back philosopher-builders. @Brendan_McCord has been building a first-of-its-kind community with @cosmos_inst - highly recommend reading his essays on AI, agency, and philosophy.
Introducing Cosmos Ventures. @_MattMandel and I are launching Fund I with $77.6M to back philosopher-builders founding institutions for the AI age. We’ve invested in AIUC (@aiunderwriting), @PrimeIntellect, Workshop Labs (acquired by @ThinkyMachines), and a stealth education company. Our LPs include @reidhoffman, @jliemandt, @StandTogether, @fredwilson, @mickymalka, and @AsteraInstitute. AI is creating the biggest opening for institution-builders since the American founding. We are here to back the founders who take it. Our thesis: Dare to Found. nitter.cf/cosmos_vc/status/21002…
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10 articles and papers we read in August 🔆📚 1/ Coasean Economics of Agent Swarms - @herbiebradley pathwaysai.org/p/coasean-eco…
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2/ What To Do As a Young Technologist in the Weirdest Hiring Market I’ve Ever Seen - @lisawehden lisawehden.substack.com/p/wh…
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in oct 2025 i signed a lease for an office in Dogpatch - literally just myself and a newly incorporated @tacitlabsco. felt like a totally ridiculous decision at the time to rent 1,800 sqft for a company that basically only existed on paper. today, we say goodbye to our faithful Dogpatch office as we’ve way outgrown it’s walls - up to 15+ in the office during the week, meetings comically spilling out to the kitchen, the park, our neighbourhood cafe. how quickly things change! we’ll be moving into 5,000 sqft in my favourite part of the Mission (Harrison & 20th). say hi if you’re in the neighbourhood! onwards 🌀
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Today @Lovable announced their AIUC-1 certification - earning the trustmark for AI agents. Congrats on passing this milestone @antonosika & @FabianHedin - proud to see the Nordics set the pace here!
Most of what Lovable does to earn your trust, you'll never see. Every app has built-in authentication, access controls, encrypted data, security scans, deployment gates, and more. It's why you won't hear us say "vibe coding" much anymore. We're way past vibes now.
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I was lucky enough yesterday to meet 30+ of Ireland's most enterprising 16- 21-year-olds at the @joinpatch_ Fellowship hosted at @dogpatchlabs in Dublin. Patch's mission is to find and accelerate Ireland's most talented youth. We spent the morning talking about startups, entrepreneurship, SF vs local ecosystems, and more. The Patch Fellowship is special because it values tinkering. As founder @carthymctom puts it: "Our job is to take these people, their interests, and ambitions seriously, and help them make the most of their gifts." Highly recommend checking their work out 🇮🇪
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Happy 250th birthday, America! I'm often asked why I decided to move to America. The honest answer is that I wanted to be in a place that champions innovation and enables entrepreneurship to thrive. You can dream of building rockets and find access to capital and talent to do so. I am so privileged to be building @plymouthstreet in San Francisco, alongside our amazing team. I am also fortunate to enable incredible customers to build their American dream (some fun snaps of @tdoggyholhol @gabriel1 @paulscherer among many others below!). Thank you, America, for welcoming me. Happy 4th everyone!
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Now that Tacit Labs and Engram are out of stealth, a casual plug for interning on the research team at @databricks: * @ninklefitz → Founder @tacitlabsco * @lindensli → Founder @appliedcompute * @dan_biderman → Founder @EngramLab * @ChrisRinard → Founder @Standard_Kernel
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Always get a lil emotional when the airport immigration officers tell me “welcome home.”
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.@demishassabis says that while mathematics is the language of physics, AI may be the perfect language for biology. @ninklefitz and @AmDroste are working to push the frontier forward here. Huge congrats on the launch of @tacitlabsco and collab with @OpenAI! Lucky beyond words to be a small part of the journey. watch this space
I've started a new company called @tacitlabsco, an applied research lab at the intersection of AI and biology. 1/n
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Thais is an absolute rockstar, and @tastelabs is on a mission to end AI slop. Extremely thankful to be an early backer. Also, kudos to almost-eponymous naming (almost like Lisa and visa 😁)
We’re excited to introduce Taste Labs. Our mission is to end AI slop. We’re building the data and infrastructure layer to give AI models and agents taste. And today we’re coming out of stealth, announcing our $18.5M seed funding, co-led by @CRV and @AmplifyPartners AI has nailed objective domains and made it easy to generate anything. But it still feels off. Now, the challenge is judgement. What fits, what feels like you, what’s GREAT. This requires turning a fuzzy, subjective domain into something we can measure and codify. We’re starting with design. There are two sides to cracking this, the foundation model layer and the agent layer: - We’ve already been working with the top frontier labs to evaluate and improve their models, crafting the right post-training data and RL environments. - We’ve also been working with app-layer companies to build the context and verification tools for their agents to produce better, more on-brand, more creative outputs. We want a future where AI feels right. If you’re passionate about this mission, join us!
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Do the hard thing. Don't do the short-term thing. Play long-term games with long-term people. Huge congrats to the @SpaceX team - Ad Astra 🚀
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Insane amount of skill & resilience to structure a deal like this - @maddiehalla is exceptional! Go team @living_carbon
1/ @OctopusEnergy is backing Living Carbon with $500M to reforest degraded land and remove CO₂ across North America. This major project financing comes with an additional ~$13M investment in our carbon business. Living Carbon is putting low quality land back to work. Our innovative reforestation turns low quality land into thriving forests faster to remove carbon or produce sustainable forest products. Read more about it in today’s @WSJ (link in the comments) →
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Cat’s out of the bag! Today @WorkshopLabs is joining @ThinkyMachines. We started Workshop Labs to build towards a world where people still matter, even as powerful AI advances. I want to talk a bit about why this is the best move to serve that mission.
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it takes a very special type of founder to capture a cultural feeling - @paulscherer's creativity and optimism are infectious, and what he's building @eigenhq is special. lucky to be part of the journey. consumer is so back, baby!
I’m honored to share that @eigenhq has raised $15M from @Benchmark to build a mutual friend that’ll help us belong and grow, together.
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