The science, business, and future of human longevity.
Joined April 2022
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Today peptides went mainstream.
Superpower Peptides is going to change healthcare forever.
I’m thrilled to announce Superpower Peptides!
For the first time, members can access prescribed peptide treatments alongside their bloodwork, clinical evaluation, and ongoing support to align with Superpower’s mission to deliver concierge health for the masses.
It took a supply chain with trusted pharmacy partners, third-party testing, clinical protocols shaped by leading doctors, and peptides produced in the USA to get here.
Superpower is redefining the relationship between you, your health data, and your care team.
Now, peptides are part of that system.
Pre-orders are open now, with the first orders shipping at the end of November.
👉🏽 superpower.com/peptides
Welcome to the new standard in peptides.
Longevity Mogul retweeted
I’m thrilled to announce Superpower Peptides!
For the first time, members can access prescribed peptide treatments alongside their bloodwork, clinical evaluation, and ongoing support to align with Superpower’s mission to deliver concierge health for the masses.
It took a supply chain with trusted pharmacy partners, third-party testing, clinical protocols shaped by leading doctors, and peptides produced in the USA to get here.
Superpower is redefining the relationship between you, your health data, and your care team.
Now, peptides are part of that system.
Pre-orders are open now, with the first orders shipping at the end of November.
👉🏽 superpower.com/peptides
Welcome to the new standard in peptides.
ANNOUNCING: Superpower Peptides.
Prescription peptide care, connected with your blood testing.
For the first time, Superpower brings prescribed peptide treatments together with membership, beginning with BPC-157, TB-500 and MOTS-c.
Each one comes with:
- Treatment prescribed by licensed providers
- Comprehensive blood testing
- Clinical evaluation
- Third-party testing
- Regular check-ins and lab monitoring
- Active ingredients from FDA-registered facilities
- Prescriptions filled by US-licensed pharmacies
Because access to peptides has often outpaced guidance.
Your health history, goals and baseline bloodwork are reviewed by a licensed clinician, who can then monitor your health throughout treatment.
We’ve been preparing for this moment.
Your can start your blood test today, and at the end of November, we’re bringing peptides to you.
Pre-orders are open now:
superpower.com/peptides
George Catlin was onto this in the 1860s.
He watched a mother "lowering her infant from the breast, and pressing its lips together as it falls asleep in its cradle."
His verdict: "such a Mother deserves to be the nurse of Emperors."
BREAKING: Long-term anabolic steroid use was linked to serious changes in heart structure and function.
Researchers also found signs of recovery in men who stopped and remained off steroids.
Source: escardio.org/news/press/pres…
ICYMI: The FDA approved the first oral PCSK9 inhibitor for high cholesterol.
Enlicitide is a peptide pill that blocks a target previously treated with injections.
Source: merck.com/news/mercks-lipfen…
Tesamorelin is FDA-approved for visceral fat in HIV, but its liver data is promising.
In a 12-month randomized trial in people with HIV and fatty liver, 35% on tesamorelin got their liver fat back to normal vs. 4% on placebo.
Interestingly, there was no real change in BMI.
The 8-hour sleep rule dates back to the 19th century.
It's an outdated idea.
A study of hunter-gatherers, whose lifestyles are closer to our ancestors and who have little or no access to artificial light, found short nights of 5.7 to 7.1 hours seemed to be enough.
Without an alarm clock, they woke close to dawn, regardless of the day of the week, and did not make up for it with long daytime naps.
The 8-hour sleep rule itself came from the notion of 8 hours of work, 8 for recreation and 8 for sleep.
If we define optimal sleep as the amount linked to the best health, many large studies suggest the sweet spot may be less than 8 hours.
1) One recent study using brain and body scans estimated the optimal amount at 6.4 to 7.8 hours, depending on sex and the organ being studied.
Sleep is a U-shaped predictor of health: both under 7 and over 9 hours are linked to adverse effects, and long sleep is often an outcome of chronic disorders, not a cause.
2) Genetics matters too.
The DEC2 P385R mutation was identified in a household where all members slept approximately 6 hours nightly without symptoms of sleep deprivation.
Guidelines advising 7-8 hours may be inappropriate for people with genetic factors that make short sleep sufficient.
Modern lighting, especially artificial light + LEDs in the evening disrupted our body clock so most of us fall asleep later than we should.
In a two-month experiment simulating Stone Age conditions, sleep increased by 1.5 hours through an earlier sleep onset.
Exposure to bright light during the day and dark during the night is ideal for circadian regulation.
And if you lose sleep during the week, catching up at the weekend appears better than not catching up at all.
I think that some people need different amounts of sleep, and when we go to sleep and wake up matters too.
All in all, I suspect we need some sort of therapeutic intervention to actually solve sleep since escaping artificial lighting is almost impossible.
I've always been obsessed with the idea of extending human life without actually having to live longer.
Of the roughly 100 billion people who have lived on Earth, no one has lived past the age of 130.
But there are thousands of people who can naturally sleep 4 hours (or less) a night, and still feel and perform as well as people who sleep 8.
What this suggests is that one of the easiest ways to extend human life might not be adding more years to the end of it, but allowing us to be awake for more if it.
Imagine this:
You can sleep for 4 hours instead of 8 without compromising your health or energy. You gain 4 additional waking hours every single day. That's about 60 extra days of conscious life every year. From age 20 to 80 you would buy back close to a decade of waking life.
And the good news is we're starting to see therapeutics being developed – sometimes peptides, sometimes small molecules – that could plausibly allow people to sleep 4 hours, but feel as if they've slept less.
One things researchers are going after at the moment is orexin. Researchers studied natural short sleepers and found that they produce more orexin during the day than others. They called it a wakefulness peptide.
Now, honestly -- I don't think orexin is fully going to get us there.
Allowing people to feel more awake is one part of the sleep equation, but that doesn't automatically mean they need less sleep, but ways to improve the efficiency of sleep. And the main challenge is that we don't really understand what improves sleep efficiency yet.
I genuinely believe we eventually get to a world where everyone can sleep less and, as a result, effectively live longer.
I'm obsessed with this because I think this is one of the most fascinating frontiers in longevity.
We spend so much time trying to live longer, but what if we could get more life out of the years we already have?
I think we'll have an answer to this in the next 10 years.
Longevity Mogul retweeted
I've always been obsessed with the idea of extending human life without actually having to live longer.
Of the roughly 100 billion people who have lived on Earth, no one has lived past the age of 130.
But there are thousands of people who can naturally sleep 4 hours (or less) a night, and still feel and perform as well as people who sleep 8.
What this suggests is that one of the easiest ways to extend human life might not be adding more years to the end of it, but allowing us to be awake for more if it.
Imagine this:
You can sleep for 4 hours instead of 8 without compromising your health or energy. You gain 4 additional waking hours every single day. That's about 60 extra days of conscious life every year. From age 20 to 80 you would buy back close to a decade of waking life.
And the good news is we're starting to see therapeutics being developed – sometimes peptides, sometimes small molecules – that could plausibly allow people to sleep 4 hours, but feel as if they've slept less.
One things researchers are going after at the moment is orexin. Researchers studied natural short sleepers and found that they produce more orexin during the day than others. They called it a wakefulness peptide.
Now, honestly -- I don't think orexin is fully going to get us there.
Allowing people to feel more awake is one part of the sleep equation, but that doesn't automatically mean they need less sleep, but ways to improve the efficiency of sleep. And the main challenge is that we don't really understand what improves sleep efficiency yet.
I genuinely believe we eventually get to a world where everyone can sleep less and, as a result, effectively live longer.
I'm obsessed with this because I think this is one of the most fascinating frontiers in longevity.
We spend so much time trying to live longer, but what if we could get more life out of the years we already have?
I think we'll have an answer to this in the next 10 years.
Everything @superpower and @maxmarchione ship looks and feels premium.
The aura on this brand is unreal.
Superpower peptides are coming soon.
99% purity, US compounded, held to a new standard. Blown away by the response to our Peptide Library.
Join the waitlist:
superpower.com/peptides
Supercentenarians (people over 110) have 4.4x the proportion of rare T cells that can kill abnormal cells vs. people aged 70–99.
Researchers think this may help protect against cancer.
It makes me think the thymus deserves much more attention in longevity.
BREAKING: A personalised mRNA vaccine cut the risk of melanoma coming back or death by 42% in a Phase 3 trial.
This is the greatest peptide library I've ever seen.
We're thrilled to announce the Superpower Peptide Library.
Every peptide, mapped to the body.
152 peptides, from approved drugs to compounds still in trials, sorted by where they act.
Each one has its own page, reviewed by a physician and fully cited, covering:
- the evidence and how strong it is
- its FDA status
- it's mechanism of action
- what studies in humans have found
Because not all peptides are equal.
Semaglutide is FDA-approved. BPC-157, maybe the most talked-about peptide for recovery and repair, is not. In a 2025 review of its research, 35 of 36 studies were in animals or the lab.
Know the science before you buy the hype.
Check it out here:
superpower.com/guides/peptid…
A US study found attractive people earned 20% more than average-looking people.
For women, that advantage disappeared after accounting for grooming (hair, makeup, clothing, and overall presentation).
Looks like looksmaxing might actually be a net positive overall.
I’m always surprised how many people still use AOD-9604 for fat loss.
Its developer ran a 536-person placebo-controlled trial, saw no meaningful weight loss advantage, and dropped the program in 2007.
In 2024, the FDA said the effectiveness evidence still isn’t there.
Longevity Mogul retweeted
New episode out now on YouTube: Peptides, AI Doctors and the End of the Annual Physical.
@maxmarchione founder of @superpower , joins @analog_kyle to talk about moving medicine from treating sickness to preventing it, through comprehensive diagnostics and AI-driven care.
They discuss who will build the “Apple of healthcare”, which AI lab is best placed to win in health, and what medicine looks like in 5 years.
Full episode, link in bio.
We're now using peptides to deliver radioactive payloads directly to cancer cells.
This treatment carries lead-212, which emits powerful alpha radiation designed to destroy tumors while limiting damage to healthy tissue.
Phase 3 is planned for 2027.
