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Lorenz Lab

@lorenz_lab

Chris Lorenz's (@cdlorenz) research group in the Department of Engineering at King's College London. Transitioning to @lorenzlab1.bsky.social

 London, UK
nms.kcl.ac.uk/lorenz.lab/wp/
Joined December 2016
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Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)Photo by Lorenz Lab (@lorenz_lab)
We’ve designed a self-assembling protein β-helix that folds into nanoscale cylinders and it’s multifunctional: 🧬 Supports cell growth 🦠 Inhibits bacteria 📦 Delivers genes Read about it in @NatureComms doi.org/10.1038/s41467-025-5… 1/7
A self-assembled protein β-helix as a self-contained biofunctional motif

A self-assembled protein β-helix as a self-contained biofunctional motif

Nature Communications - The structure-function relationships of a β-helix, a folding motif formed by parallel β-strands arranged in a helical repetitive pattern, remain poorly understood...

nature.com
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This is an example of how rational design of protein folds can lead to multifunctional biomaterials - combining mechanics, bioactivity, and delivery in a single motif. 6/7
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It was a lot of fun collaborating with this amazing team including the groups of Max Ryadnov (@NPL) & Bart Hoogenboom (@uclmaps) ! #biomaterials #proteinengineering #synbio #NatureCommunications @kcl_engineering @KingsNMES 7/7
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Our latest manuscript to be published introduces PUCHIK (bit.ly/3QeqbT4), a novel & efficient Python package designed for the analysis of molecular dynamics simulations of nanoparticles, w/ a focus on accurately describing the interfaces of aspherical nanoparticles. 1/10
Image from Lorenz Lab (@lorenz_lab)
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The efforts of so many people have resulted in numerous manuscripts being published in close succession. Hrach Ishkhanyan & Alejandro Santana Bonilla did all of the hard work in this case. @KCL_Physics @KingsNMES @kcl_engineering @eResearch_KCL @KingsCeRch @IIAP_ASNET_AM 9/10
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PUCHIK means 'balloon' in Armenian, which is home for Hrach and is also a well-suited name for the nanoscale objects that we hope to facilitate the understanding of with this code. 10/10
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Our latest manuscript presents the most recent tools available in the PySoftK software package (bit.ly/4jQps8i). PySoftK now helps scientists analyse molecular simulations of soft materials, w/ tools for analysing interfaces, molecular interactions, & self-assembly 1/7
Image from Lorenz Lab (@lorenz_lab)
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The code and tutorials can be found via the PySoftK website: bit.ly/3CXXML3 ... If you want to here a podcast summarising the latest in PySoftK then here is a link: bit.ly/3WUJSmT 6/7
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Thanks to the amazing Alejandro Santana-Bonilla (@KingsCeRch) , Rob Ziolek (@kvantify) & Raquel López-Ríos de Castro (@ChariteBerlin) for doing all of the hard work! 7/7
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