Stefano Cheloni (@lost_efano) header
Stefano Cheloni (@lost_efano) profile picture

Stefano Cheloni

@lost_efano

Bioinfo Expert at @SophiaGenetics. Cancer and clinical genomics. Previously postDoc @IEOufficiale & PhD @SEMM_it. Nature & evolution enthusiast, waves chaser.

 France
Joined October 2011
  • Tweets64
  • Following455
  • Followers95
6Media
Photo by Stefano Cheloni (@lost_efano)Photo by Stefano Cheloni (@lost_efano)Photo by Stefano Cheloni (@lost_efano)Photo by Stefano Cheloni (@lost_efano)Photo by Stefano Cheloni (@lost_efano)Photo by Stefano Cheloni (@lost_efano)
📣 We are teaming up with @MSKCancerCenter and @AstraZeneca for a groundbreaking mission! Read more in the full announcement: 🔗 loom.ly/36yFOOg #AIinHealthcare #CancerResearch
Image from SOPHiA GENETICS (@SOPHiAGENETICS)
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We’re proud to announce our collaboration with Memorial Sloan Kettering Cancer Center to further cancer research through #DataDrivenMedicine. #SOPHiNVESTORDAY @MSKCancerCenter
Image from SOPHiA GENETICS (@SOPHiAGENETICS)
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Neil Hall (@neilhall_uk) profile picture
Neil Hall@neilhall_uk24 Jan 2020
This should be included in compulsory training for academics - most bioinformaticians will read panel 3 and cry into their coffee
James McInerney (@jomcinerney) profile pictureJames McInerney@jomcinerney23 Jan 2020
This is a bit intense but that doesn’t make it less true. I had somebody visit me about ten years ago and panel 3 is a synopsis of what she said to me.
Image from James McInerney (@jomcinerney)
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Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3174…
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Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol18 Nov 2019
A very under-studied yet important consequence of #cancer therapies: the mutations they induce nature.com/articles/s41588-0… @NatureGenet by @nlbigas @oriol_pich @fmuinos @IRBBarcelona and their colleagues
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
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Andy Coenen (@_coenen) profile picture
Andy Coenen
@_coenen5 Nov 2019
Understanding UMAP - a high-level introduction to how the algorithm works, how to use it effectively, and how it compares with t-SNE. pair-code.github.io/understa…
Understanding UMAP

Understanding UMAP

UMAP is a new dimensionality reduction technique that offers increased speed and better preservation of global structure.

pair-code.github.io
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Luca Pappalardo (@lucpappalard) profile picture
Luca Pappalardo@lucpappalard28 Oct 2019
⚽️ We just released on #Nature @ScientificData the largest dataset of spatio-temporal events in soccer matches: one season of 8 soccer competitions! 1⃣ Paper 👉 nature.com/articles/s41597-0… 2⃣ Blog post 👉 bit.ly/soccerdata_post #SportsAnalytics #SciComm #DataScience #PlayeRank
Image from Luca Pappalardo (@lucpappalard)
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what’s a work life balance and should we buy one for the lab
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Some thoughts on the recent discovery that some solid tissues become colonised by mutant clones carrying cancer mutations as we age. genomemedicine.biomedcentral…
Image from Inigo Martincorena (@imartincorena)
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Jamie Blundell (@jrblundell) profile picture
Jamie Blundell@jrblundell7 Mar 2019
Which somatic variants in blood are most “pathogenic”? How does mutation, drift and selection shape the genetic diversity in our blood? Why is clonal haematopoiesis age dependent? Data from 50,000 individuals points to a simple answer...biorxiv.org/content/10.1101/…
The evolutionary dynamics and fitness landscape of clonal haematopoiesis

The evolutionary dynamics and fitness landscape of clonal haematopoiesis

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance, however,...

biorxiv.org
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EMBL (@embl) profile picture
EMBL@embl7 Mar 2019
Today is #WorldBookDay! 📗 A shout-out to @wolfgangkhuber and Susan Holmes for writing their book 'Modern Statistics for Modern Biology', and making it freely available online for scientists & teachers worldwide: bit.ly/2tR9Cmf (for print: bit.ly/2HgKdtP)
Image from EMBL (@embl)
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Genome Biology (@GenomeBiology) profile picture
Genome Biology@GenomeBiology22 Jan 2019
We asked members of our editorial board what they thought was going to happen next in genomics. This is what they said: genomebiology.biomedcentral.…
Where is genomics going next?

Where is genomics going next?

Genome Biology - We polled the Editorial Board of Genome Biology to ask where they see genomics going in the next few years. Here are some of their responses.

link.springer.com
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Arjun Raj (@arjunrajlab) profile picture
Arjun Raj
@arjunrajlab5 Dec 2018
For grants, the strategy is then clear. Only spend time making grants good enough (not perfect), and then write as many as possible.
Richard Sever (@cshperspectives) profile pictureRichard Sever@cshperspectives5 Dec 2018
“peer review system is not substantially better than random selection in identifying the best candidates once an initial pre-selection of the most promising ones is performed” biorxiv.org/content/early/20…
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Anirban Maitra (@Aiims1742) profile picture
Anirban Maitra@Aiims174218 Oct 2018
The “Beat AML” initiative (sponsored by @LLSusa & led by Brian Druker @OHSUKnight) paper was published in @nature yesterday. Functional genomic landscape of acute #Leukemia (including a data browser for making genotype phenotype correlations) nature.com/articles/s41586-0…
Image from Anirban Maitra (@Aiims1742)
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Mutation detection in thousands of acute myeloid leukemia cells using single cell RNA-sequencing. Interesting to see how scRNA-seq cell state and subclonal mutations coincide in some cases. Does this indicate differential lineage commitment? biorxiv.org/content/early/20…
Image from Moritz Gerstung (@MoritzGerstung)
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The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize1 Oct 2018
BREAKING NEWS The 2018 #NobelPrize in Physiology or Medicine has been awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”
Image from The Nobel Prize (@NobelPrize)
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Sohrab Shah (@SohrabShah) profile picture
Sohrab Shah@SohrabShah7 Sep 2018
What can we learn from sequencing the whole genomes of 40,000 cells across diverse tissues? Joint work with @sajraparicio is posted. Thank you to all the people in both labs for collaborating in an inspiring way to produce this work. biorxiv.org/content/early/20…
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Neil Saunders (@neilfws) profile picture
Neil Saunders@neilfws16 May 2018
I can't imagine what software could have caused this problem cell.com/cell/fulltext/S0092…
Image from Neil Saunders (@neilfws)
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Cell Press (@CellPressNews) profile picture
Cell Press@CellPressNews9 Apr 2018
The #PanCancer Atlas - a one-of-a-kind #openaccess collection of #cancer research from the #TCGA, now published in @CellCellPress & other Cell Press journals. @NCIgenomics bit.ly/2GJpQGF
Image from Cell Press (@CellPressNews)
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Cell (@CellCellPress) profile picture
Cell@CellCellPress9 Apr 2018
#PanCan analysis of enhancer expression in nearly 9000 patients indicates global enhancer activation correlates with #aneuploidy but not #mutations cell.com/cell/fulltext/S0092… #openaccess #cancer #TCGA @MDAndersonNews
Image from Cell (@CellCellPress)
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