Photosynthesis Lab using systems and synthetic biology to research the molecular basis of global carbon fixation #photosynthesis @UniOfYork #UKRIFLF
University of York
Joined October 2016
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Luke Mackinder retweeted
Take a look at this stunning artwork made by local school children during our 2nd outreach workshop.
#STEMeducation #outreach
Luke Mackinder retweeted
Our new review is out now – well done Ella, Sabina, Nicky and Charlotte – a great collaboration with the @mackinderlab!
From algae to plants: understanding pyrenoid based CO2-concentrating mechanisms. sciencedirect.com/science/ar…
Check out this Research Briefing for a quick overview of our work exploring Rubisco condensation by CsLinker, an intrinsically disordered protein from Chlorella. All driven by @james_r_barrett doi.org/10.1038/s41477-024-0…
A promiscuous algal Rubisco binding protein that binds to the large subunit, can condense plant Rubiscos and functionally complement an epyc1 mutant. Congrats @james_r_barrett + great team effort @Mihris_N,@mjplevin,@McCormick_Lab,@JNB_lab,@YorkBioimaging. doi.org/10.1038/s41477-024-0…
Luke Mackinder retweeted
Diatom PyShells help fix 20% of the Earth's #CO2🌍. Luke, Onyou, & team -- It was a great pleasure collaborating with you on this very exciting project. So much to explore in the diverse world of marine algae!🌊🦠🪸
A blueprint of the diatom pyrenoid reveals a Rubisco encapsulating protein Shell is critical for CO2 fixation. Is it essential for global NPP? Congrats to @OnyouNam,@james_r_barrett,@ItsCarolineMck,@JNB_lab + great collab with @DemulderManon,@bengeliscious.doi.org/10.1016/j.cell.2024.…
A blueprint of the diatom pyrenoid reveals a Rubisco encapsulating protein Shell is critical for CO2 fixation. Is it essential for global NPP? Congrats to @OnyouNam,@james_r_barrett,@ItsCarolineMck,@JNB_lab + great collab with @DemulderManon,@bengeliscious.doi.org/10.1016/j.cell.2024.…
Luke Mackinder retweeted
Some of the amazing, microscopic algae and animals that float at the sea surface. (From my plankton net tows) It is shocking that this vital world of life is so overlooked by natural history TV programmes. In fact, I'd say it is a dereliction of duty. @zeiss_micro
Luke Mackinder retweeted
Evolution of Thylakoid Structural Diversity!🌱🦠🌍
Annemarie's deep dive🤿 into the wide wild world of photosynthetic complexes and thylakoid architecture and is now available open access @AnnualReviews.
She also made beautiful figures🎨. Check it out!
annualreviews.org/content/jo…
Luke Mackinder retweeted
The final version of our PyShell🥧🐚 paper is now online @CellCellPress. Check out how diatoms soak up 20% of the Earth's #CO2!🌏
📜 sciencedirect.com/science/ar…
Brilliant work by @DemulderManon, @Jorgendottir, Ginga, Aki, Giovanni, Genji, Yusuke, and all the rest of our collabs 🤗
Meet the PyShell!🥧🐚 Diatom pyrenoids fix up to 20% of the Earth's #CO2🌏. We discovered that their Rubisco is encased in a tight protein lattice that is essential for efficient carbon fixation and cell growth🌱
Super excited to share our new preprint📜: biorxiv.org/content/10.1101/…
Luke Mackinder retweeted
Our preprint on the interplay between algal CO2 concentrating mechanism and photorespiration is now available.
We have identified LCI20 as a new player in algal photorespiration that delivers amino groups for mitochondrial glycolate metabolism. biorxiv.org/content/10.1101/…
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Luke Mackinder retweeted
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
biorxiv.org/content/10.1101/…
Another major hurdle overcame in plant pyrenoid engineering to enhance CO2 fixation - how to traverse the Rubisco condensate with thylakoid membranes. Congratulations @JonikasLab @McCormick_Lab @JHennacy @NickyJAtkinson
Excited to share our latest preprint!
Biogenesis, engineering and function of membranes in the CO2-fixing pyrenoid
biorxiv.org/content/10.1101/…
Great to be part of this multi-disciplinary project. See the insightful thread by @CharlSchaef explaining how we worked across disciplines to predict phase diagrams that we experimentally validated #pyrenoid
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A game changer in chloroplast engineering. We are already hugely benefitting from the tools. Well worth reading the thread to see how it was achieved
Very excited to share the preprint of a big chapter of my PhD, where I am corresponding & shared first author (together with @gitanguy) about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas:
Below in a 🧵:
biorxiv.org/content/10.1101/…
Luke Mackinder retweeted
Super happy to have contributed in a small way to this monumental effort by René et al.! This is a really amazing piece of work that significantly advances our ability to engineer chloroplasts.
Very excited to share the preprint of a big chapter of my PhD, where I am corresponding & shared first author (together with @gitanguy) about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas:
Below in a 🧵:
biorxiv.org/content/10.1101/…
Luke Mackinder retweeted
Out from our lab: a toolbox for chloroplast engineering . Paving the way towards synbio in chloroplasts. Fantastic work by @rene_inckemann @gitanguy @CedKB @michaelcburgis and labs of @FWillmund @mackinderlab @james_r_barrett biorxiv.org/content/10.1101/…
Luke Mackinder retweeted
What a super meeting! With creative new ways to do research at the beautiful edges of physical and life sciences you really really can make transformative progress that, frankly, will have global and long-lasting impact… @PhysicsofLifeUK – at Tollerton, England
And that's a wrap. Thanks to all for coming and thanks also to the sun for showing up just in time for the group photo
@bengeliscious @MariaHondele @fern_way @LabRichter @omc111 @McCormick_Lab @mackinderlab @JonikasLab @lau_gunn @gatesfoundation @EPSRC @BPSIYork @PhysicsofLifeUK
Luke Mackinder retweeted
On this #phycologyfriday I am happy to announce an open #PhD position!
We aim to increase CRISPR efficiency and study carbon capture in the green seaweed Ulva
➡️Advert: floppy.psb.ugent.be/index.ph…
➡️Apply via ugent.be/en/work/scientific/…
‼️Deadline May 15th!
@GenomePlant @PhycologyUgent
CsLinker: an algal pyrenoid assembly protein that binds the RbcL, complements across 800 My of evolution and phase separates plant Rubisco. Very excited to share this work by @james_r_barrett, @JNB_lab, @mjplevin, @BPSIYork, @McCormick_Lab. @JonikasLab doi.org/10.1101/2024.04.09.5…
