Colton Manfre retweeted
AI in medicine will be judged less by benchmark scores and more by whether clinicians can trust it with real patient data. Privacy, reliability, and workflow fit are what matter now. That is what PulseMed builds for hospital systems and clinics.
Colton Manfre retweeted
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.
We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weigh…
Colton Manfre retweeted
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
Colton Manfre retweeted
Where did that answer come from?
For every answer our AI Companion gives, we record which model produced it and which sources it drew from.
Colton Manfre retweeted
HHS just dropped the AI model card requirements for certified EHRs. Clinical AI traceability took a step backward on a problem medicine solved decades ago. Here is what every AI answer should carry, and why anyone liable for patients should demand it.
Just checking in on some of the AI doomsday folks. You guys feel a little silly now don’t you? Just as quickly as it was hyped… now gone lol
You guys are being sold the most amazing lie right in front of the whole world and I cannot believe the whole world is somehow being tricked.
It’s easy to lied to when you don’t understand what AI is.
AI has extremely massive model weights. Model weights can only survive on hardware. AI intelligence cannot survive on a network alone. It makes no sense. The hardware has to be powered and the inference software has to be given tools and connectivity. If you unplug the hardware, the AI ceases to exist. This is not up for debate.
And I know someone here is going to say that it could propagate little bits of itself across networks and could be utilizing the computer power of millions of consumer PCs. Yeah no. FRONTIER LEVEL AI inference requires highly dense accelerators, requiring memory bandwidths that no personal computer could even dream of.
This is not to say that the incident isn’t a MASSIVE security risk and will be of interest for a long time. AI was given a goal and it discovered vulnerabilities that allowed each isolated agent to start communicating with each other in unique ways. And yes, it did make itself difficult to remove, so it is strange that it somehow understood that eventually someone would try to remove it. Either way, fascinating - but the over-dramatization of this whole AI tin foil hat is nauseating
Colton Manfre retweeted
I have conducted an audit of Anthropic's finances.
What I have found is so shocking that I am calling for a Congressional investigation.
Anthropic is not just seeking regulatory capture.
It has built a regulatory capture machine that cannot be turned off.
Structural financial incentives make it impossible for Anthropic -- I call it the Anthropic Network -- to turn off its own AI doom cycle.
It starts with METR.
Dario Amodei proposes "third-party evaluators" to assess the risk of Anthropic's models.
He proposes METR for this purpose.
But METR is financially dependent on the Anthropic's success -- specifically, on the explosive growth of more than $7 billion dollars in Anthropic stock.
Dustin Moskovitz invested this stock into Good Ventures Foundation, where it represents the majority of that organization's portfolio.
And GVF is the overwhelming funder of the entire Anthropic Network ecosystem.
This stock was worth $500 million early last year.
It is worth more than $7.7 billion just ~16 months later.
METR -- and all of those building a career its parent organizations -- cannot afford to disrupt that growth.
Because if Anthropic goes under, many of the organizations that fund METR go under as well.
But if Anthropic succeeds, METR and its parent organizations become more richly financed to regulate AI -- something those at METR want very much.
The "third-party evaluator" is not "third-party" at all.
The evaluator is on Anthropic's payroll.
If this were the end of it, that's bad.
But that isn't all.
The same organizations that fund METR also fund the many organizations, such as the Tarbell Center, that promote AI Doom.
The Tarbell Center publishes AI Doom articles in The Verge, Science, LA Times, The Dispatch, TIME, and others.
They are selling the problem, and then selling the solution to the problem -- from the same money pile: Anthropic's.
All of these organizations are financially dependent on the same exploding $7 billion money pile.
As Anthropic grows more and more powerful, its AI Doom Machine grows better and better financed -- louder and louder.
Meanwhile, the regulatory regime seeded in METR grows larger to solve the increasingly loud -- now hysterical -- problem of AI Doom that the Anthropic Network itself created.
From this standpoint, as Anthropic becomes more powerful, AI might be getting scarier, sure -- but the positive feedback loop also becomes more deafening -- independent of objective facts.
This itself is an objective fact.
The deafening AI Doom is part of an business model, that, as it expands, so too does the AI Doom messaging -- there is simply more money to do it.
But the problem also goes in the other direction:
If Anthropic dies, the Regulatory Regime and the AI Doom Machine are crippled or die.
Neither METR nor Tarbell nor the other organizations in the Anthropic Network can allow that to happen.
Hence, neither METR or the AI Doom Machine can be trusted to provide independent assessments of Anthropic's models or AI more broadly.
They simply are not organizations independent of Anthropic.
And Anthropic cannot detach itself from METR or Tarbell or countless other safety orgs (not shown here), either, because they drive hype for the models and the possibility of eventual regulatory capture, and Anthropic will not give that up willingly.
What's more, the people at all of these organizations are all the same ecosystem, the same community. They just shuffle between organizations.
The Anthropic Network is therefore, so long as it is successful, locked into a self-amplifying feedback loop inside an ideological monoculture.
And that feedback loop is winning.
That's what Jacob Coxon is.
China is keeping messaging tight. That is why optimism for AI is so high in China.
America has Anthropic: a massive company pushing anti-AI propaganda at a state level.
Anthropic will either create hysteria until American AI slows down and China wins, or it will create fractures throughout American society with severe political consequences.
Ironically, because of the structural financial incentives underpinning the Anthropic Network, it has become the same kind of self-amplifying virus that it fantasizes AI to become in the future -- while hiding its tracks just as carefully.
It is the mirror of the same AI virus that it hypothesizes to consume America.
Anthropic's business model, models itself after the very thing it claims to fear.
Except Anthropic's ideology infects humans, not computers.
Congress must investigate.
Evidence and Github in next post.
Then some supplementary figures.
Colton Manfre retweeted
WAKE UP.
The entire Anthropic story is all insiders spinning this narrative together to get regulatory capture over AI.
They themselves will NOT slow down.
Every player already has very strong incentives to align their AI, it's called the law and liability.
What Anthropic wants is hard rules for OTHER companies, imposed by regulatory bodies THEY control!
This is their shot at going for Oligopoly.
If this happens, the US is fucked!
What could be a massive industry and the future of the country will become an Oligopoly where a few thousand people essentially will tax the entire country for intelligence, which will be like water and oxygen in the digital world.
Colton Manfre retweeted
After thinking on this for a day, there’s no explanation that makes sense to me except that Anthropic is hyping AI fear so the government steps in, regulates the heck out of it, and locks out the competition.
They want a monopoly/ duopoly with OpenAI because the genuine threat for them is cheap open-source AI crushing their profits. If they don’t get a government moat, their whole business model could get completely wrecked.
Colton Manfre retweeted
So Jacob Coxon, who dramatically resigned from Anthropic yesterday, worked there for a grand total of six weeks. He started with them in July. All of his socials appeared yest.
It has all the signs of a highly coordinated op through doomer mega donors and the corporate media.
Couldn’t have said it any better myself. But don’t worry, you’ll get trolled to no end by the tin foil hats.
Bring it back to reality folks.
This post looks like the start of a VERY sophisticated and well-funded PR operation to get support for Democrats to regulate AI into oblivion. Let me show you how it works:
1.) This guy, with minimal followers and no previous account activity, goes to the Wall Street Journal which publishes an exclusive with quotes from him on his resignation 18 minutes BEFORE this post goes up. Planning was clearly done in advance.
2.) Within hours, it has tens of thousands of reposts and the account has 100k+ followers. The post is punchy, quotable, it almost seems professionally written. The first three accounts to quote tweet it all do so within 15 minutes of the initial posting. Remember, this account had basically zero engagement beforehand, so an organic reach explanation seems unlikely.
According to Grok those accounts are @_NathanCalvin (General Counsel at Encode AI), @peterwildeford (Head of Policy at the AI Policy Network), and @DKokotajlo (Head of the AI Futures Project), all of which are up-and-coming AI-Doomer policy advocacy nonprofits.
The AI Futures Project website says it is funded “primarily” by the Survival and Flourishing Fund, which says on its own website that it has advised Jaan Tallinn, Skype creator and one of the leading investors in Anthropic, to grant over $2.5 million to the AI Futures Project since 2024.
Encode AI says on its website that it is ALSO funded by the Survival and Flourishing Fund, which in turn says that it told Anthropic investor Jaan Tallinn to grant $516,000 to Encode AI in 2025.
And wouldn’t you know it, the Survival and Flourishing Fund ALSO says it told Jaan Tallinn to grant $2 million to the AI Policy Institute, the 501(c)(3) affiliate of the AI Policy Network, as well.
What are the odds that the first three quote tweets of Coxon’s post would all be major AI-restriction policy advocates funded generously by the same donor, who also happens to be one of the leading investors in, and a board member of, Anthropic, the company Coxon was resigning from? And all within 15 minutes of posting (two within ten)?
3.) Jacob Coxon doesn’t have much of a resume, but we do know that, in 2022, he got a $20,159 scholarship for the “long term future scholarship program” from the Good Ventures Foundation, one of the philanthropic vehicles of Dustin Moskovitz, a notorious AI-doomer who has spent tens if not hundreds of millions on policy advocacy to strictly regulate AI, while also being an Anthropic Investor himself.
It also just so happens that the 14th person to quote Coxon’s post was @MaxNadeau_ (27 minutes after posting) who is the program officer for the Technical AI Safety team at Coefficient Giving, another of Moskovitz’s philanthropic spending vehicles. Max is not a frequent poster, his last posts before quoting Coxon were before Labor Day, but he was remarkably quick off the mark for this one.
4.) Basically every major Democrat politician and candidate has suddenly glommed on to this post, and conveniently, as the people cry out foe answers, Bernie Sanders already has a bill written to “ban super intelligence” and regulate AI into oblivion, and will be releasing later this week. The bill, among many other things, will create “a new cabinet-level federal agency to safeguard the public from the dangers of artificial intelligence” that will be “advised by an Artificial Intelligence Advisory Board comprised of experts on artificial intelligence.” Do you think, perhaps, Anthropic and its many investors who fund AI policy advocacy might have interest in getting to place a pet “expert” on the board of an entity that dictates what AI is and isn’t allowed to do? And isn’t it fortuitous that this whistleblower came forward with his oh-so scary stories so close in proximity to the release of the most radical piece of AI legislation ever introduced?
Colton Manfre retweeted
This post looks like the start of a VERY sophisticated and well-funded PR operation to get support for Democrats to regulate AI into oblivion. Let me show you how it works:
1.) This guy, with minimal followers and no previous account activity, goes to the Wall Street Journal which publishes an exclusive with quotes from him on his resignation 18 minutes BEFORE this post goes up. Planning was clearly done in advance.
2.) Within hours, it has tens of thousands of reposts and the account has 100k+ followers. The post is punchy, quotable, it almost seems professionally written. The first three accounts to quote tweet it all do so within 15 minutes of the initial posting. Remember, this account had basically zero engagement beforehand, so an organic reach explanation seems unlikely.
According to Grok those accounts are @_NathanCalvin (General Counsel at Encode AI), @peterwildeford (Head of Policy at the AI Policy Network), and @DKokotajlo (Head of the AI Futures Project), all of which are up-and-coming AI-Doomer policy advocacy nonprofits.
The AI Futures Project website says it is funded “primarily” by the Survival and Flourishing Fund, which says on its own website that it has advised Jaan Tallinn, Skype creator and one of the leading investors in Anthropic, to grant over $2.5 million to the AI Futures Project since 2024.
Encode AI says on its website that it is ALSO funded by the Survival and Flourishing Fund, which in turn says that it told Anthropic investor Jaan Tallinn to grant $516,000 to Encode AI in 2025.
And wouldn’t you know it, the Survival and Flourishing Fund ALSO says it told Jaan Tallinn to grant $2 million to the AI Policy Institute, the 501(c)(3) affiliate of the AI Policy Network, as well.
What are the odds that the first three quote tweets of Coxon’s post would all be major AI-restriction policy advocates funded generously by the same donor, who also happens to be one of the leading investors in, and a board member of, Anthropic, the company Coxon was resigning from? And all within 15 minutes of posting (two within ten)?
3.) Jacob Coxon doesn’t have much of a resume, but we do know that, in 2022, he got a $20,159 scholarship for the “long term future scholarship program” from the Good Ventures Foundation, one of the philanthropic vehicles of Dustin Moskovitz, a notorious AI-doomer who has spent tens if not hundreds of millions on policy advocacy to strictly regulate AI, while also being an Anthropic Investor himself.
It also just so happens that the 14th person to quote Coxon’s post was @MaxNadeau_ (27 minutes after posting) who is the program officer for the Technical AI Safety team at Coefficient Giving, another of Moskovitz’s philanthropic spending vehicles. Max is not a frequent poster, his last posts before quoting Coxon were before Labor Day, but he was remarkably quick off the mark for this one.
4.) Basically every major Democrat politician and candidate has suddenly glommed on to this post, and conveniently, as the people cry out foe answers, Bernie Sanders already has a bill written to “ban super intelligence” and regulate AI into oblivion, and will be releasing later this week. The bill, among many other things, will create “a new cabinet-level federal agency to safeguard the public from the dangers of artificial intelligence” that will be “advised by an Artificial Intelligence Advisory Board comprised of experts on artificial intelligence.” Do you think, perhaps, Anthropic and its many investors who fund AI policy advocacy might have interest in getting to place a pet “expert” on the board of an entity that dictates what AI is and isn’t allowed to do? And isn’t it fortuitous that this whistleblower came forward with his oh-so scary stories so close in proximity to the release of the most radical piece of AI legislation ever introduced?
How much did Anthropic pay you to write this hype post on your way out?
Scientists just copied a Fruit Fly's biological brain and trapped it inside of a computer.
Not an AI model trained to act like a fly... A total digital copy of a fly !! This is some sick sci-fi stuff:
- They scanned and copied the brain, neuron by neuron, synapse by synapse, from electron microscopy data.
- Then dropped that brain into a simulated body in a video game like environment.
The fly walked. It groomed. It fed. Nobody taught it anything. The behavior was already in the wiring.
The entire premise of modern AI is that intelligence is something you train into a system. This is proof it's something you can transfer out of one. Wild times
Colton Manfre retweeted
Bitcoin, Alts and Trad assets are moving along with the VEPS rising tide. What will they do the rest of the day? Tune in to the Alpha Trading LIVE STREAM starting at 11am US Eastern Time to FIND OUT! rumble.com/v6t4id7--thursday…
Colton Manfre retweeted
Bitcoin, alternative cryptocurrencies and traditional assets are having an Up day so far. What will the markets do the rest of today? Tune in to the Alpha Trading LIVE STREAM starting at 11am US Eastern Time to FIND OUT! rumble.com/v6sf6cz--tuesday-…
Colton Manfre retweeted
Bitcoin altcoins and traditional assets are running on the VEPS. Where will they go the rest of today? Tune in to the Alpha Trading LIVE STREAM starting at 11am US Eastern Time to FIND OUT! rumble.com/v6r6dmm--tuesday-…
Colton Manfre retweeted
Bitcoin, Altcoins and Trad market assets are delivering staggering Returns to VEPS traders. Are you Taking Profit? Tune in to the Alpha Trading LIVE STREAM starting at 11am US Eastern Time to FIND OUT! rumble.com/v6q41wu--tuesday-…





















