mark.heidel (@markheidel2) profile picture
Oro Valley, AZ
Joined December 2022
Photo by mark.heidel (@markheidel2)Photo by mark.heidel (@markheidel2)
mark.heidel retweeted
What if the brain's electrical connections are much smarter than we thought? Electrical synapses are specialized connections that allow brain cells to communicate directly through tiny channels called gap junctions. Unlike chemical synapses, which rely on neurotransmitters to carry messages between neurons, electrical synapses permit rapid communication through the direct flow of electrical current. Alberto Pereda and Adam Miller describe in a new review in Nature Reviews Neuroscience why we may need to rethink what an electrical synapse actually is, and how it works. Key points: - Electrical synapses are not simply passive channels connecting neurons. They are dynamic structures capable of changing the strength of communication between brain cells. - Gap junctions are supported by a complex network of proteins, including connexins, scaffolding proteins and regulatory molecules that control how electrical signals are transmitted. - Neurotransmitters such as dopamine, synaptic activity and molecular processes can modify electrical coupling, suggesting that electrical synapses may play a much more sophisticated role in brain plasticity and network function than previously appreciated. My take: This review resonates w/ me because it challenges a fundamental assumption about how the brain communicates. For decades, we have frequently thought about electrical synapses as relatively simple connections and chemical synapses as the more adaptable and sophisticated partners. That distinction may be misleading. Electrical synapses can change, adapt and interact w/ chemical signaling systems. As someone who spends much of my time thinking about Parkinson's disease, dopamine and deep brain stimulation (DBS), I find this particularly fascinating. We frequently focus on which brain circuits are firing abnormally and how stimulation can alter their activity. However, could we also be missing an important part of the story by not paying enough attention to how neurons are electrically connected and how those connections change? This is a basic neuroscience review, not evidence that manipulating electrical synapses will improve DBS outcomes, however it opens important questions for future research. Here are 5 points that resonated w/ me: 1- Electrical synapses are not fixed electrical wires. Their strength can change depending on brain activity and the molecular environment. 2- Dopamine may influence more than chemical signaling. It can also regulate electrical communication between neurons, a fascinating concept when thinking about Parkinson's disease. 3- The proteins surrounding gap junctions may be just as important as the channels themselves. The machinery supporting a connection can influence how that connection functions. 4- Electrical and chemical synapses do not operate in isolation. Their interactions may help explain how brain circuits adapt, synchronize and process information. 5- Could understanding electrical synapse plasticity eventually help us develop smarter neuromodulation approaches, including more personalized DBS? We do not yet know, however this is an exciting direction worth exploring. nature.com/articles/s41583-0…
6
75
4
322
10,223
mark.heidel retweeted
Islam has a 1400 year pattern. Small minority: peace and harmony. Reach critical mass in a population: increasing aggression. Majority: everyone else subordinated. Starts with Muhammad himself. Rinse and repeat for 14 centuries. How is this hard? youtu.be/TwK1Y3jdwEs?si=zCEy…
3
1
12
325
mark.heidel retweeted
Live by the sword, die by the sword. Those who pick fights with me should understand that I will find out who is really pulling the strings and come for them, not just their puppets …
18,718
37,695
3,803
266,273
11,593,384
THE SUMMITS – the figures every field is measured against. Bach was the Shakespeare of music, Aristotle of philosophy, Homer of poetry, Newton of science, Euclid of mathematics, Michelangelo of art. Last for today: the American Founders, the Shakespeare of statecraft – the only summit that is a team. 1. Washington, Jefferson, Adams, Madison, Hamilton, Franklin. Rivals, quarrelling, sometimes hating each other. Yet together they wrote the oldest national constitution still in use. Separate voices, each singing its own line, held together in one order. Bach's counterpoint, played by politicians. 2. They were the best-read political class in history. They had studied Aristotle, Cicero, Locke and every republic that had ever failed – and why. Before building, they compared. They didn't invent from nothing; they stood on every shoulder available. The whole idea of this series, in one room in Philadelphia. 3. They built for human nature as it is. "If men were angels, no government would be necessary," wrote Madison. Since men are not angels, ambition must be set against ambition: three branches, each watching the others, a machine of checks and balances. Paris did the opposite a few years later – built for man as he should be – and got the Terror. In Europe, only Poland was attempting something similar at the time. 4. Rights come from the Creator, not from the government. That one sentence decides everything. What the state did not give, the state cannot take away. Most constitutions list what the government will do for you. The American one is mostly a list of what it cannot do to you. 5. Washington could have been king. The army would have followed him. Instead he gave up his command and went home to his farm – and later, as president, left after two terms. King George reportedly said that if he did that, he would be the greatest man in the world. The summit of statecraft is a man walking away from power. 6. Signing the Declaration of Independence was treason. Every man who put his name on it was signing his own death sentence if the war was lost. They pledged "our lives, our fortunes and our sacred honor" – and meant it literally. Today's politicians risk a bad poll. The Founders risked the rope. Statecraft without personal risk becomes management – and management never founded anything. 7. When the Convention ended, a woman asked Franklin what kind of government they had made. "A republic, if you can keep it." That is the catch. Every other summit in this series stands on its own once built. This one must be climbed again by every generation – or it becomes a monument to something that no longer exists. Shakespeare tells us who we are. Bach tells us what we're for. Aristotle tells us how to tell the difference. Homer tells us where we come from. Newton tells us the universe can be understood. Euclid tells us how to know we're right. Michelangelo shows us what a human being can become. The Founders show us how free people can govern themselves – and that every generation must earn it again, or lose it for the next.
THE SUMMITS – the figures every field is measured against. Musk called Bach the Shakespeare of music. It's a framework worth following: in every field there is one figure who is not in the canon, but what the canon is measured against. Civilizations are remembered by these heights. Next up: Aristotle, the Shakespeare of philosophy. 1. He didn't contribute to a field. He founded most of them. Logic, ethics, politics, biology, physics, rhetoric, poetics – walk through any university and half the department names are his. He is not a philosopher among others. He is the floor the others stand on. 2. Logic first. He wrote down the rules of valid reasoning: if this and this, then necessarily that. It sounds obvious. Nobody had done it before. Every proof, every legal argument, every line of code is a distant grandchild of his syllogism. The engineer and the philosopher share one ancestor. 3. In Raphael's School of Athens, Plato points up to the heavens. Aristotle holds his hand flat, toward the earth. That is the great fork of the West. Plato looked for perfect ideas; Aristotle looked at the world as it is. Science was born on Aristotle's side: observe, classify, test. 4. Start from what is, not from what should be. Before writing on politics, he collected and compared the constitutions of Greek cities. Evidence first, theory after. Every utopia does the opposite – it starts from an idea of the perfect city and forces people to fit. Communism is Plato's Republic run by commissars. 5. Excellence is a habit. We become just by doing just acts, brave by doing brave acts. Not lightning, not talent – repetition. Bach writing a cantata every week was pure Aristotle. Virtue, like music, is trained. 6. Man is a political animal. We become fully human only inside a community – family, city, laws. Not the lone individual of modern fantasy, not the anthill of the collectivist. Free people inside a common order: Bach's counterpoint, two thousand years earlier. 7. And the West lost him too. For centuries most of his works vanished from Latin Europe; Byzantine and Arab scholars kept them. When they came back in the Middle Ages, Aquinas built Christian thought on them, the universities grew around them, and science followed. The torch didn't just change hands – it crossed civilizations and came home. Shakespeare tells us who we are. Bach tells us what we're for. Aristotle tells us how to tell the difference. Lose him, and we keep the words but lose the thinking.
8
27
5
80
10,459
AI needs massive, reliable clean energy to scale. ⚡ Copenhagen Atomics CEO Thomas Jam Pedersen presented last week at @SwissRe's Engineering Underwriting Forum 2026 highlighting how containerized thorium molten salt reactors can unlock base-load power for data centers. #NuclearEnergy #Thorium #DataCenters #SwissRe2026
1
6
133
Jack answers: Could Wall Street control Bitcoin the way it controlled gold and silver?
14
44
1
259
41,386
The Useful Idiot: A Natural History Specimen: Western, educated, well-meaning. Habitat: universities, NGOs, quality newspapers, dinner parties where the wine is good and the opinions are better. Status: abundant. The useful idiot is not exactly stupid. This is the first and most important thing to understand. Stupidity would be a defense. The more precise diagnosis is what we in Poland call pół-inteligent – the half-wit. Not the bottom of the intelligence distribution, which is too obviously lost to be useful. Not the genuine top, which tends to develop the inconvenient habit of following arguments wherever they actually lead. The sweet spot: smart enough to absorb a complex ideological framework, to deploy its vocabulary with confidence, to feel the social rewards of appearing sophisticated – but not quite sharp enough to interrogate the framework itself. Enough horsepower to run the program. Not enough to question who wrote it. The pół-inteligent is the useful idiot’s technical specification. And the specimen is typically convinced – this is crucial – that it is among the most independent thinkers in the room. The delusion is important. Remove it and the whole architecture collapses. The species emerges in conditions of comfort and safety, which is why it proliferates in precisely the societies it works to undermine. It requires a baseline of security – enough that the consequences of being wrong about power remain abstract, theoretical, someone else’s problem. Eastern Europeans, who paid in flesh and decades for the privilege of understanding what the useful idiot enables, are able to see this as naivety so profound it becomes a moral failure. Not innocence. Culpable ignorance dressed as virtue. Observe the specimen in its natural habitat. It discovers The Cause sometime between the ages of 18 and 24, usually at an institution of higher education, usually through social contagion rather than solitary reasoning. The Cause varies by generation – Soviet sympathies, third-worldism, postcolonial theory, current-year identity grievance – but the structure is invariant: a clean division of the world into oppressors and oppressed, a designated villain class, and a role for the specimen as enlightened ally. The emotional reward is immediate and substantial. Belonging. The claim of moral clarity. The warm superiority of the awake among the sleeping. What the specimen does not perceive – what it is structurally prevented from perceiving – is that it is being used. Lenin coined the phrase, and he meant it with cold precision. The useful idiot is not a partner in the project. It is infrastructure. It provides legitimacy laundering: translating raw power-seeking into the language of justice, making the predatory appear compassionate, and doing so with enough genuine conviction to be convincing. The cynics who run the operation cannot do this themselves – cynicism is legible. True believers are required. The useful idiot’s sincerity is its primary value to those who deploy them. And so Lenin used them – and so does Islam now. The specimen’s lifecycle has a melancholy third act that it rarely anticipates. When the project advances far enough – when the institutions are captured, when the Overton window has moved sufficiently – the useful idiot becomes inconvenient. It knows too much about the earlier, more honest phase. It has friendships across the new fault lines. It retains, sometimes, inconvenient principles from when principles were the point. The revolution, as it industrializes, prefers newer models: fully formed apparatchiks with no memory of idealism to complicate their loyalty. The useful idiot is retired, marginalized, occasionally denounced by the very movement it spent decades building. It dies puzzled. It never quite understands what happened. We've all seen the very surprised lady in Paris... History is littered with these figures. Western intellectuals who defended the Soviet project through the show trials, the Holodomor, the Gulag – and who spent the rest of their lives in various stages of retrospective rationalization. Fellow travelers who called Solidarity troublemakers, who thought the dissidents were exaggerating, who trusted the official version over the testimony of people who had lived it. Their names are recorded. Their counterparts today are producing content, signing letters, and occupying endowed chairs. The useful idiot is not the enemy. It is the weapon. Understanding the difference matters – because the weapon can, in principle, be disarmed. It requires only one thing: contact with reality at sufficient intensity and duration to override the social rewards of the delusion. This happens. Some recover. Eastern European experience – the unignorable, undeniable, lived reality of what the project actually produces – has cured more than a few. The cure is not pleasant. It requires admitting that one’s most cherished moral identity was constructed by people who found it useful. That the independence one prided oneself on was curated. That the dinner party consensus was not wisdom but a lie. Most cannot make this admission. The identity investment is too great. They double down instead – find new framings, new rationalisations, new ways to explain why this time is different, why the critics are the real problem. They remain, to the end, useful.
The look of someone discovering reality. This young woman stood in front of a smashed shop window in Paris last night and said the smashing and looting are not what the cause is about. She still believes the people who broke the glass share her cause. They don’t. They have their own. This is not how she imagined it. It has a name: cognitive dissonance – the pain of watching reality contradict what you were told to believe. She learned it last night, in pain. Millions of others will learn it in the coming months – the same way. Because reality doesn’t need the media. It comes through the window. We were right all along.👇🏻 And they were wrong. So will they admit it now, and let go of their delusions? Or will they double down? In 1954, an American psychologist infiltrated a small cult that had predicted the end of the world on a precise date. The date came. Nothing happened. Did the believers give up? The most committed did the opposite: they started preaching harder than ever. That is what most true believers will do. Admitting the error would cost them their friends, their careers and their image of themselves. So they will blame the police, the "far right," the economy, the weather – anything but the idea. For them to change their minds, their whole system will have to collapse – the salaries, the institutions, the friends who all think alike. Belief survives as long as the group survives. We have seen it before: in 1989, when the system fell, Poland’s communists woke up one morning as social democrats – and a good number of them as businessmen. But the believers are not the audience. The people watching are. Reality rarely converts the priests. It converts the congregation – one broken window at a time. And yesterday was much more than a broken window. A day like that must have opened the eyes of millions. Events like that change history. The priests will keep preaching. The congregation has already started to leave.
168
1,152
153
3,609
127,388
The claim in this video is that I'm identical to Tucker Carlson in damaging the Republican Party, which I actually hear out in the world pretty often, and I guess that's a mythology about me now. It's not true, of course, and it's another of these Woke "different things are the same" games, in fact. Tucker is using destructive lies and awful views to attack the Republican Party, until recently from within and now quite explicitly. I am not. I told the truth about Tucker early and at high cost and didn't back down or stop when called names, resisted, and punished, including by NatCon, which has apparently realized Tucker has gone too far now (several years too late, after hosting him themselves and defending him and his friends, like Kevin Roberts and JD Vance, to this very day). What we do is not the same, not the same at all. He lies. I tell the truth. I want Republicans to win. He wants them to lose. He wants to take individual Republicans into evil. I want to pull them away from it. And this is only a beginning. This is a farce. More than that, it's a moral failure in slow retreat. NatCon got this wrong. I got it right. I was the bad guy, and now I'm even more of the bad guy. They're still failing on issue after issue, and that's their fault, not mine. I'm pointing at what they don't want pointed at, but the thing I'm pointing at involves them. I am not opposed to NatCons being in the Republican coalition at all, unlike with Tucker. I am opposed to them driving. I am opposed to them setting the agenda. They are the junior partners in this coalition, especially in these United States, and they need to get used to it. I'm not opposed to their stupid debates, although I think they're worse than a distraction right now. I don't even think they're real debates because to me the U.S. Constitution is the first and last word here. No new conservatism for some new nationalism needed. That doesn't make me a "libertarian." It makes me an American Patriot, thank you very much. It is my operating premise that to win elections, to be a worthy party, to be a big coalition, it must coalesce around widely popular, virtuous, and true things, not a fringe splinter, not resentment, not hate. I therefore think Tucker Carlson should be recognized as outside of the party, movement, etc. I also think NatCon's weird nationalist game is unacceptable. Big coalitions are not feasible around weird fringe ideas until after everything is broken, broken the way Tucker is trying to break them. This fever dream, to use the term, is madness, especially now. A lot of people, not just "Lindsayites" see it, hence the backlash. I resent these comments and all they aim to do, which is the same thing as the rest of what NatCon is actually trying to do: make themselves the new center of gravity for the Republican Party in the United States, which isn't just foolish but a losing idea. I said no. I still say no. I will keep saying no.
32
52
3
377
24,315
Well, that was wild. I'm at the Australian Parliament and just left a meeting with two staffers for the governing party. They told us that the government needed more power to censor things like the upcoming US execution of Nidal Hasan. When I asked why they needed to censor that video, one said it was to prevent copycat killings. Copycat killings by governments? I asked. Er, no, they said. Copycat killings like of a backpacker, several decades ago. So, under that logic, I pointed out, the government should censor things like last year's Bondi massacre, where two Muslims killed 15 people, no? Well, that was news, they said. Didn't they realize their bill would allow the government to censor news? They didn't seem to know, or care. They also admitted that they did not know that the bill would allow the government to create and operate an unlimited number of fake social media accounts to attack its political enemies and spread disinformation. Having presented them with information they had never heard about a bill they had clearly not read, they emphasized to us, strenuously, that they were moving forward with the bill. So there you have it. The government wants the power to arbitrarily censor scenes of violent crime, or violence, for any reason. And it wants the power to use an unlimited number of fake accounts to wage offensive disinformational warfare against the Australian people. Given that the Bondi massacre last year increased public opposition to mass migration, and support for the populist One Nation Party, it seems obvious that the government wants to censor such events in order to protect its political power. It's quite telling how obediently governing party members insist such a law is needed without even knowing what's in it.
1,316
10,062
714
37,277
853,024
mark.heidel retweeted
Nassim Taleb made an intellectual career defending Fat Tony against the Intellectual Yet Idiot, but he forgot to remove the beam from his own eye.
Taleb is the best evidence that you can write books like the Black Swan and still lose all rationality, and the ability to articulate an actual argument, due to Israel derangement syndrome. Meanwhile, the only thing wrong with Kasparov's comparison is that the bomb maker may have actually advanced the study of chemistry.
2
3
2
48
2,973
What would it take to produce ten times more energy than today? ⚛️ At the Paul Scherrer Institute colloquium, our CEO Thomas Jam Pedersen explained why the answer runs through thorium: the only route to breeding in a thermal spectrum, at a raw fuel cost more than 1,000x below solid uranium fuel. Here's why👇 copenhagenatomics.com/news/t… #Thorium #NuclearEnergy
2
5
1
18
527
mark.heidel retweeted
NEVER SIGN IN WITH GOOGLE NEVER SIGN IN WITH GOOGLE NEVER SIGN IN WITH GOOGLE NEVER SIGN IN WITH GOOGLE NEVER SIGN IN WITH GOOGLE NEVER SIGN IN WITH GOOGLE NEVER SIGN IN WITH GOOGLE
1,617
2,797
400
36,115
11,642,068
mark.heidel retweeted
How I think about AI capability and AI safety. (Thanks to @dbongino for asking some great questions.)
10
20
3
82
13,290
I mean, I care, but Republicans need to win the midterms regardless. The Democrats have not gotten better. They have gotten worse.
I really don’t care what’s happening in the Republican Party right now because we can fight over what the hell is going on after we win the midterms. Handing over the country to a bunch of lunatics on the left is not the solution. Stopping Trump from being able to do anything for the next two years is the single dumbest decision you could ever make and it makes you a democrat. Everybody should be voting and bringing 10 people with them. And anybody telling you otherwise isn’t a conservative. No matter how bad you think things are right now, they will be significantly worse if the Marxists control Congress.
26
66
3
972
19,657
Never Go Full Tucker
237
607
51
5,054
307,083
🚨 JUST IN: Crypto comes home to America! 🇺🇸 The CFTC just went around a stalled Congress and laid out a framework to bring crypto markets onshore. Finally! This is so bullish....a new era for crypto in America. Here I explain simply what this means.
20
78
7
640
24,252
I am Iranian, and it gives me no pleasure to say this. I say it because I have already lived through what you still treat as unthinkable. But Paul is right. 250,000 armed men can take a huge number of lives in 48 hours. Ten months ago, on 8 and 9 January, it happened in Iran. A relatively small number of regime IRGC gunmen killed at least 72,000 people. That is the latest figure President Trump has said was documented. I believe the real number is higher. @DouglasKMurray once said that Westerners cannot really imagine what religious fanatics are like, and that despite all the rhetoric, everything changes when the other man might kill you. Most people in England still cannot picture it. They think what happened in Iran on those two days, or what happened on 7 October, is a horror reserved for other people, in other places. It is not. You are not immune. Not at all. Your politicians have brought the same kind of men into this country. IRGC, Hamas and Hezbollah supporters. No vetting. They live among you. Many of them are sleeper cells. They have not been activated, YET. The people who were supposed to protect you are in bed with the same terrorists. Last month the US Treasury Secretary, @SecScottBessent , said on camera that Washington knows where the regime’s accounts sit in trust companies in the British Virgin Islands, and knows the hundred-million-dollar houses it owns around the world. Regime’s new leader, Mojtaba Khamenei, has been linked by a Bloomberg investigation to more than £100 million in luxury London property, held through intermediaries. That is the tip of the iceberg. So when I say something is going on behind the scenes, that is not a conspiracy theory. They announce that the IRGC is banned, that diplomatic ties are cut, and so on. It is a sham. UK has been one of the biggest lifelines the Islamic regime has had. I warned long ago that a parallel power structure was being built in the mosques, the community centres, and elsewhere. An army is being assembled. Once it is deployed, it will be too late. They may not be able to take over UK, but they certainly can inflict an unimaginable pain on you. They hate you enough for that. There is a reason they are called death cult. Not long ago @manototv released a documentary, “This Is Our Story“, cut from footage of 8 and 9 January in Iran. I will put the YouTube link here. Watch it, and send it to the friend who is not political, who is not here in X, the liberal, the person who still defends this immigration madness and cannot see the monster growing in the dark. Tell them, you are not immune to this. Wake up before it is too late. youtube.com/playlist?list=PL…
Just to make you fully aware of our position as white Brits living in Britain: 250,000 armed Islamic men could wipe out most of the population of Britain within 48 hours. Communism and Islam killed millions in the 20th century. Our current Home Secretary is a revolutionary communist and Islamic fundamentalist. She is now engaged in importing weapons trained Palestinians and Afghans. 250k possible Afro-Islamic soldiers illegally crossed the channel over the last few years and now reside, at vast government expense, in military barracks and hotels strategically placed across the country. The British government could easily arm these men, in pursuit of revolutionary ideals. All Labour Ministers are Fabians and as such ARE revolutionary communists. I appreciate my view sounds insane, but here's the thing: the conditions DO exist for mass slaughter. Our governments have allowed these conditions to exist. In terms of national security, the conditions should never have been allowed to exist. When conditions exist, and exist only because of massively expensive and and massively logistical government actions, then they exist for a reason.
73
1,859
111
4,984
383,430
mark.heidel retweeted
If you haven't seen this watch now. It will knock you over I haven't seen anyone from Liberal Inc engage this logically. What even is the response? We are forced to paint Helen Joyce into The Monster, the fascism, the far-right, the not-science, the hate?
They have destroyed their children who will now be seen as freaxish if more parents don't do the same, and time is growing short
108
1,162
105
3,873
136,414
mark.heidel retweeted
1. The latest post in my series on why ‘capitalism’ and ‘capitalist’ are such misleading terms. Life is anti-entropic. It is how purpose gets into the universe.
1
2
7
184