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Mayu Inaba

@mayuinaba0317
 Connecticut, USA
health.uconn.edu/germline-stem-cells/
Joined March 2017
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Dinner with my old friend Mo! Thank you for coming.
Image from Mayu Inaba (@mayuinaba0317)
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Mystery of transposon expression in fly spermatocytes! biorxiv.org/content/10.64898…
Fertility Gene Introns Harbor Transposable Elements that Shape Y-Loop Architecture

Fertility Gene Introns Harbor Transposable Elements that Shape Y-Loop Architecture

Transposable elements (TEs) are powerful drivers of genome evolution, yet how they persist under selection and become incorporated into host regulatory networks remains poorly understood. In the...

biorxiv.org
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Never really said this clearly before, even though it seems obvious "asymmetric division sustains stem cell heterogeneity" is now out. Huge credit to our former grad student Burak for driving this, and to Boris Slepchenko, a best collaborator nature.com/articles/s42003-0…
Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche

Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche

Communications Biology - Mathematical modeling of the Drosophila testis stem-cell niche reveals how asymmetric division of stem cells delays clonal expansion and preserves stem cell heterogeneity.

nature.com
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Protocol to evaluate a lineage marking system in the Drosophila testis sciencedirect.com/science/ar…
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We took extremely long time to publish this. Finally its out on Communications Biology! nature.com/articles/s42003-0…

Stem cells resume asymmetric division upon niche re-entry through reactivating the centrosome...

Communications Biology - Long-term live imaging in Drosophila testis shows that dedifferentiated germline stem cells re-acquire stem cell behaviours, including the centrosome orientation...

nature.com
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Plasticity and stringency: rethinking stem cell division modes portlandpress.com/biochemsoc…

Plasticity and stringency: rethinking stem cell division modes

Asymmetric cell division (ACD) has been extensively studied in various stem cell systems as a fundamental mechanism that ensures the balance between stem cell self-renewal and differentiation. ACD...

portlandpress.com
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New preprint from the lab! We explore how a single niche signal can have two distinct effects. Check it out! Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells biorxiv.org/content/10.1101/…
Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells

Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells

Drosophila male germline stem cells (GSCs) reside at the testis tip, surrounding a cluster of niche cells known as the hub. Bone Morphogenetic Protein (BMP) ligands secreted from the hub exert both...

biorxiv.org
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FlyBase needs your help! Because of recent changes to government funding, the NIH grant that supported FlyBase has been terminated. Please click here for more information and to contribute: wiki.flybase.org/wiki/FlyBas…
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Standing octopus
Image from Mayu Inaba (@mayuinaba0317)
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Cute crab
Image from Mayu Inaba (@mayuinaba0317)
Image from Mayu Inaba (@mayuinaba0317)
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Adheena's last day. Lab will miss you🥲
Image from Mayu Inaba (@mayuinaba0317)
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Paige Bueckers, a UConn legend
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WELCOME THE CHAMPIONS HOME 🏆 Ticket claim goes live at 7pm. UConn students can claim at UConnHuskies.com/studnets. Fans can claim at UConnTickets.com 🎟️
Image from UConn Huskies (@UConnHuskies)
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Fly testes are always busy
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Saxophone RNAi testis was selected for this cover. Congratulations, Emma!
Image from Mayu Inaba (@mayuinaba0317)
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In @eLife: Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad doi.org/10.7554/eLife.103035
Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans...

Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans...

The mirror-symmetric structure of the Caenorhabditis elegans gonad is established through the Wnt-independent function of a Frizzled protein and three Wnt proteins with distinct roles.

elifesciences.org
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An RNA binding regulatory cascade controls the switch from proliferation to differentiation in the Drosophila male germ line stem cell lineage biorxiv.org/content/10.1101/…
An RNA binding regulatory cascade controls the switch from proliferation to differentiation in the...

An RNA binding regulatory cascade controls the switch from proliferation to differentiation in the...

The switch from precursor cell proliferation to onset of differentiation in adult stem cell lineages must be carefully regulated to produce sufficient progeny to maintain and repair tissues, yet...

biorxiv.org
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Published: our study on a new Drosophila gene Moat shows strong polarity-based junctions allow weak myosin to promote productive apical constriction, leading to ectopic folding of ectodermal anterior midgut (ectoAMG). The ectopic folding requires Baz/Par3. molbiolcell.org/doi/full/10.…
Image from WengFlyLab (@WengFlyLab)
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See: doi.org/10.1038/s41556-024-0… A close-up view of mRNA organization and regulation during active translation in germ granules! Congrats to Roy Chen, William Stainier, and our collaborators Jeremy Dufourt and Mounia Lagha! @NatureCellBio!
Direct observation of translational activation by a ribonucleoprotein granule

Direct observation of translational activation by a ribonucleoprotein granule

Nature Cell Biology - Chen et al. perform single-molecule imaging of translation at ribonucleoprotein (RNP) granules. They show that RNP granule surfaces are sites of nanos mRNA translation,...

nature.com
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😬🙂
Sanjeev Galande (@SanjeevSaGa) profile pictureSanjeev Galande@SanjeevSaGa5 Jun 2024
Thank you @kalikapg and Dasarathi for lucidly summarizing the multiple sessions presented at CMMDR2024 meeting held at @ShivNadarUniv @dls_snioe. Beautiful artwork (bookmarks) featuring model systems at this meeting by @TheNunJay. For complete report see doi.org/10.1242/dev.203023
Image from Sanjeev Galande (@SanjeevSaGa)
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