Mary Makarious (@mbmakarious) header
Mary Makarious (@mbmakarious) profile picture

Mary Makarious

@mbmakarious

egyptian/مصرية 🇪🇬𓂀 • @DataTecnica • currently @NIH studying neurodegen. *omics 🧬🧠 • @geno_ml core dev • @LoyolaChicago @UCLIoN alumna • she/her

 washington dc-ish
Joined August 2012
  • Tweets419
  • Following564
  • Followers376
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Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)Photo by Mary Makarious (@mbmakarious)
Lucky to have such a cool hometown – at Cairo, Egypt
Image from Mary Makarious (@mbmakarious)
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Mary Makarious retweeted
Mike A. Nalls (@mike_nalls) profile picture
Mike A. Nalls@mike_nalls30 Apr 2024
GP2 release 7 is now live!!! Massive effort from great collaborators across @DataTecnica , @NIHAging , @Verily , MJFF and @ASAP_Research to get this done. Check out the release that is now live on Verily Workbench and Terra.
Image from Mike A. Nalls (@mike_nalls)
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Mary Makarious retweeted
Mike A. Nalls (@mike_nalls) profile picture
Mike A. Nalls@mike_nalls14 Mar 2024
Paper out! Federated learning for multi-omics: A performance evaluation in Parkinson’s disease TL/DR: Federated learning particularly in a boosted framework is comparable to central analyses ... let's start learning across data silos now! cell.com/patterns/fulltext/S…
Image from Mike A. Nalls (@mike_nalls)
Image from Mike A. Nalls (@mike_nalls)
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M&M at it again - honored to present this morning in the beautiful Cartagena about future directions, analyses, and data for @ASAP_Research's GP2! – at Cartagena, Colombia
Mike A. Nalls (@mike_nalls) profile pictureMike A. Nalls@mike_nalls8 Feb 2024
Lucky to team with the amazing @mbmakarious to talk data engineering for accelerating #openscience at @ASAP_Research GP regional meet in Cartagena. Sidenote, the dual monitors are quite bright. 🫥 📸 @SingletonNeuro
Image from Mike A. Nalls (@mike_nalls)
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Get some rest and use this as the reason (after reading this) 😴
Mike A. Nalls (@mike_nalls) profile pictureMike A. Nalls@mike_nalls10 Nov 2023
Get some sleep! Sleep issues in 2M samples show risk of neurodegeneration 15 years out and compensates for low genetic risk. Check the link for a break down of our preprint from a collaboration between the UKDRI, NIH's CARD and @DataTecnica. datatecnica.com/blog/working…
Image from Mike A. Nalls (@mike_nalls)
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Mary Makarious retweeted
DataTecnica (@DataTecnica) profile picture
DataTecnica@DataTecnica12 Oct 2023
New blog post on our proof of concept for federated learning applications in healthcare. datatecnica.com/blog/federat… We show in a multi-modal precision medicine application, federated machine learning is comparable to centralized data efforts but is safe and efficient across silos!

Federated learning in multimodal healthcare data [preprint] — Datatecnica

Data silos are a huge issue in machine learning, particularly in the healthcare and biotech settings. This can be due to distributed servers or cloud localities, policy barriers like GDPR, or people...

datatecnica.com
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Mary Makarious retweeted
sara bandres (@BandresSara) profile picture
sara bandres@BandresSara14 Sep 2023
Hats off to this trio of outstanding scientists for their huge contributions to the field of PD genetics. Congrats to my mentor @SingletonNeuro - Thanks for your tireless effort, perseverance and a never-give-up attitude. What a daily source of inspiration!
Breakthrough (@brkthroughprize) profile pictureBreakthrough
@brkthroughprize14 Sep 2023
Congratulations to Thomas Gasser, Ellen Sidransky and Andrew Singleton, who win the 2024 Breakthrough Prize in Life Sciences for discovering key genetic risk factors for Parkinson's disease. breakthroughprize.org/News/8… @NIHAging @NIH @genome_gov @DZNE_en @uni_tue
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Mary Makarious retweeted
Mike A. Nalls (@mike_nalls) profile picture
Mike A. Nalls@mike_nalls14 Sep 2023
Proud of our guy @SingletonNeuro !!!
Breakthrough (@brkthroughprize) profile pictureBreakthrough
@brkthroughprize14 Sep 2023
Congratulations to Thomas Gasser, Ellen Sidransky and Andrew Singleton, who win the 2024 Breakthrough Prize in Life Sciences for discovering key genetic risk factors for Parkinson's disease. breakthroughprize.org/News/8… @NIHAging @NIH @genome_gov @DZNE_en @uni_tue
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So honored to be part of GP2 and be a part of this work! 😊
Sonya Dumanis (@SoDumanis) profile pictureSonya Dumanis@SoDumanis26 Aug 2023
Check out @ELeap29 blog on #GBA1Discovery and the way #GP2research is pioneering collaborative science gp2.org/collaborative-scienc…
Collaborative Science Unlocks GBA1 Discovery

Collaborative Science Unlocks GBA1 Discovery

With the discovery of the first genetic risk factor for Parkinson’s disease (PD) that is specific to people of African ancestry, it is impossible not to be excited about where the Parkinson’s field...

gp2.org
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(1/2) Thanks to @NewsHour for giving me the opportunity to chat with @johnyangtv about the groundbreaking #GBA1discovery from @ASAP_Research's #GP2 researchers! Intentional #collaboration + #inclusive research paves the way for #discoveries 🙌🏾🙌🏾 We're moving full speed ahead!
PBS News (@NewsHour) profile picturePBS News
@NewsHour27 Aug 2023
New research has identified a genetic variant that increases the risk of Parkinson’s in people of African descent, and is not seen in those with European ancestry. @johnyangtv speaks to @ELeap29 for more.
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👏👏👏
Thiago Peixoto Leal (@ThiagoPeixotoL) profile pictureThiago Peixoto Leal@ThiagoPeixotoL25 Aug 2023
Today I presented my project on #GP2AIM. It is a pleasure to talk about the ancestry in association studies and the positive impact in addressing this information in the studies. Let's make science more inclusive
Image from Thiago Peixoto Leal (@ThiagoPeixotoL)
Image from Thiago Peixoto Leal (@ThiagoPeixotoL)
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Out now in @Brain1878! 🥳 Here, we conduct the first large-scale study to investigate rare variant associations of Parkinson's disease risk at a genome-wide scale. In total, we looked at 7,184 PD cases, 6,701 proxy cases, and 51,650 healthy controls
The Science of Parkinson's (@ScienceofPD) profile pictureThe Science of Parkinson's@ScienceofPD25 Jun 2023
New research from @mbmakarious @cornelisblauw & colleagues presents the largest #Parkinsons genetic burden test to date; identifying GBA1 & LRRK2 as 2 genes harboring rare variants associated with PD & nominating several other previously unidentified gene academic.oup.com/brain/advan…
Image from The Science of Parkinson's (@ScienceofPD)
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However, further research into the biological mechanisms is critical to confirm the role of these genes in PD. Further replication in larger datasets that prioritize familial PD cases and non-European ancestry will provide greater insight into all nominated genes
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Link to the manuscript can be found here: academic.oup.com/brain/advan…
Large-scale rare variant burden testing in Parkinson's disease

Large-scale rare variant burden testing in Parkinson's disease

Makarious et al. investigate the contribution of rare genetic variants, with minor allele frequencies <1%, to Parkinson’s disease risk. They confirm the

academic.oup.com
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Our own @C_WSolsberg @halsty and friends from NIH CARD 🧬 identify novel AD loci by leveraging diversity across populations @UCSFmac – at Miguel Hidalgo, Distrito Federal
Mike A. Nalls (@mike_nalls) profile pictureMike A. Nalls@mike_nalls18 May 2023
And another one … @C_WSolsberg and @HamptonLLeonard cranking out #AlzheimersDisease multi-ancestry meta-analysis #GWAS. With some deep dives into heterogeneity of effects and risk prediction implications. Team effort from NIH’s CARD and friends! nature.com/articles/s41380-0…
Image from Mike A. Nalls (@mike_nalls)
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Mary Makarious retweeted
Mike A. Nalls (@mike_nalls) profile picture
Mike A. Nalls@mike_nalls18 May 2023
Been a great day for publications from the team. @mkoretsky1 and the team great job on showing genetic overlap and in some instances a depletion of genetic risk across and within neurodegenerative diseases. – at Nashville, TN
Image from Mike A. Nalls (@mike_nalls)
The Science of Parkinson's (@ScienceofPD) profile pictureThe Science of Parkinson's@ScienceofPD18 May 2023
Genetic risk factor clustering within and across neurodegenerative conditions (such as #Parkinsons, #Alzheimers, #ALS) - from @HamptonLLeonard & colleagues; "Neurodegenerative diseases have more overlapping genetic etiology than previously expected" academic.oup.com/brain/advan…
Image from The Science of Parkinson's (@ScienceofPD)
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Mike is right, Chelsea Alvarado (twitterless 🥲) and @HamptonLLeonard's exciting work here is just the beginning... 🙏
Mike A. Nalls (@mike_nalls) profile pictureMike A. Nalls@mike_nalls14 Apr 2023
New preprint from the team at CARD, nominating novel drug targets for neurodegenerative disease using multi-omic and genetic data. Hoping this is a starting point for community target discovery specifically focused on ADRD. medrxiv.org/content/10.1101/…
Image from Mike A. Nalls (@mike_nalls)
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