Methylene Blue (@methblue_) header
Methylene Blue (@methblue_) profile picture

DeSci longevity lab testing Methylene Blue 🪱 C. elegans 30.8% 🪰 Drosophila — running 🐁 Mouse — funding backed by @pumpdotscience 💬 https://nitter.cf/t.co/FszHgrYL3w

Joined March 2024
this video is a short summary of what we built this year around methylene blue. real experiments. real data. real results. this is what decentralized science looks like when it actually works — running on crypto rails. if you’re building in solana or care about decentralized science, sharing this helps more than you think. proving decentralized science works through real experiments. thanks @pumpdotscience ticker: $MBLUE
22
12
4
56
6,973
Methylene Blue retweeted
New news: Life Biosciences will present first-in-human data from the Phase 1 trial of ER-100 in optic neuropathies at the Eyecelerator Conference in New Orleans, Oct, 8, 2026, 2:10PM CT 👀
82
170
34
2,065
115,879
Methylene Blue retweeted
Glycine is about to become as popular as creatine.
22
9
8
206
118,925
Methylene Blue retweeted
methylene blue experiment results
24
2
36
938
Methylene Blue retweeted
September $APITE $SRRK
Your GLP-1 patient loses 50 pounds. Somewhere between 12 and 20 of those pounds are muscle. Patients on semaglutide or tirzepatide who hit 20 to 25% weight loss give up 25 to 40% of it as lean mass. They lose the tissue that protects metabolic health, functional independence, and balance in a fall. Myostatin explains the mechanism. Every muscle carries this built-in growth limiter, also called GDF-8. It signals through the activin type IIB receptor and turns on transcription factors that suppress protein synthesis and drive breakdown. Follistatin binds myostatin and neutralizes it, so the balance between the two sets how much muscle a patient keeps. Here is the cruel part. Myostatin rises with aging, immobilization, chronic disease, and weight loss. The brake squeezes hardest at the moment your patient needs muscle most. Three programs to know: Apitegromab targets latent myostatin activation. The SAPPHIRE Phase 3 trial in spinal muscular atrophy met its primary endpoint. The FDA issued a Complete Response Letter in September 2025 over manufacturing observations. Scholar Rock resubmitted in March 2026, with a PDUFA date in late September 2026. In obesity, the EMBRAZE Phase 2 trial combined apitegromab with tirzepatide in 100 patients. The combination group took 85% of their loss from fat and 15% from lean mass. Tirzepatide alone ran 70% fat and 30% lean. That gap preserves about 4.2 pounds of lean mass‼️ Regeneron tested a different approach in COURAGE. Semaglutide alone gave up 33% of weight loss as lean mass🚨 Adding trevogrumab cut that loss roughly in half. Read the tolerability data on the triple combination. It hit a 28.3% discontinuation rate with muscle spasms as the most common adverse event. Two deaths occurred in that group. Regeneron identified no causal association with the study drugs. The events still argue for careful patient selection. None of these agents carries approval for muscle preservation today. So measure what you can and act on what works now. Track lean mass with DEXA, and add grip strength and gait speed for function. Prescribe protein at 1.6 g/kg per day and resistance training three times a week the day you start the GLP-1. The pharmacology arrives in the next few years. Your patient loses the muscle this year. The future of medicine is bright, especially peptides and that’s why I created the @peptavo course.
1
1
138
Methylene Blue retweeted
2
5
105
Methylene Blue retweeted
The “steroid killer” might finally be real. Myostatin inhibitors are doing something we’ve never really had a drug do before: Lose fat. Preserve muscle. And potentially increase lean mass. Apitegromab. Bimagrumab. Trevogrumab. Garetosmab. The data is getting VERY interesting—but there’s a massive catch almost nobody is talking about. Here’s everything we know so far 👇
28
22
6
400
74,159
Methylene Blue retweeted
New Claude Science update is out. My favorite feature: Claude can now see CPU and memory usage across all its running kernels and adjust its own workloads. And you get the same view through the new compute dashboard. From the dashboard, you can interrupt (or kill) running kernels to reclaim resources and even send the agent feedback (e.g. "rerun using fewer CPUs").
10
11
1
144
11,724
Methylene Blue retweeted
The Bio community is on the ground in New York this month. Two stops: Catalyst NYC by @ResearchHub (translational science, funding models, open science infra) and DeSciNYC's Peptides 101 session. If you're building in material science, enzyme engineering, microbial strain engineering, or small molecule discovery, DM @oxMichelangelo. We want to meet. Links to the events ↓
13
14
95
9,985
Methylene Blue retweeted
⚛️DeSci Atoms Market Update 2 June 2026 MarketCap 24hrs Top Gainers 1. Clarity Protocol ( $FOLD ) +40.40% @clarity_proto 2. MBLUE ( $MBLUE ) +12.24% @methblue_ 3. Spark ( $spark ) +6.09% @spark_sciences Overall DeSci Atoms Marketcap Total Market Cap: $568,666,185.77 -2.58% Total 24hrs Volume: $260,931.31 +11.01%
2
9
384
💙
⚛️DeSci Atoms Market Update 30 May 2026 MarketCap 24hrs Top Gainers 1. PYTHIA ( $PYTHIA ) +31.53% 2. Rejuve Token ( $RJV ) +12.50% 3. MBLUE ( $MBLUE ) +11.99% @methblue_ Overall DeSci Atoms Marketcap Total Market Cap: $606,976,826.77 -0.64% Total 24hrs Volume: $470,452.85 +44.83%
4
224
Methylene Blue retweeted
⚛️DeSci Atoms Market Update 30 May 2026 MarketCap 24hrs Top Gainers 1. PYTHIA ( $PYTHIA ) +31.53% 2. Rejuve Token ( $RJV ) +12.50% 3. MBLUE ( $MBLUE ) +11.99% @methblue_ Overall DeSci Atoms Marketcap Total Market Cap: $606,976,826.77 -0.64% Total 24hrs Volume: $470,452.85 +44.83%
1
1
1
6
537
new UI new features new products nododesci.com/
3
146
METHYLENE BLUE is powerfully anti-aging for the skin. Here's how: Methylene blue applied to skin cells reverses aging. The left two columns are cells from a 30 year old. The right two from an 84 year old. Those blue dots quantify senescence of skin cells, or cellular aging. Methylene blue reverted the aging status of the 84 year old skin cells to that of the 30 year old. Methylene blue also completely protected skin cells from dying and even increased the number of skin cells. If your skin is deteriorating, that is exactly what you want. Methylene blue also increases the thickness and function of the dermis, the layer just beneath the surface This layer is critical for providing nutrients and energy to the surface along with clearing out waste and pathogens, giving your epidermis that glow and smoothness. Methylene blue ALSO increased the hydration of the skin, by improving the function of the dermis, again the layer of tissue just beneath the surface of the skin. Methylene Blue seems to work on a fundamental level to enhance skin health. Collagen is a protein bundle that specifically make up our connective tissues like skin, hair and nails, supporting the structure of these unique tissues. Methylene blue topically applied to the skin actually stimulates the formation of our own endogenous collagen proteins. Fibroblasts are cells that secrete collagen. Methylene blue supports the formation of these fibroblasts in skin, tripling their numbers, meaning we get more skin regeneration. It also helps to heal wounds. In fact, methylene blue can also regenerate the cells of the skin itself, more than doubling the amount of skin cells derived from 84 year old skin cells. Methylene blue is a potent antioxidant in the skin. It even outperforms some of our endogenous antioxidants in that regard. This oxidation is a primary driver behind all aging and degeneration, but especially in the skin where it breaks down the tissue over time. Methylene blue protects against skin cells against potential damage and aging from the UV-B rays of the sun, through this same mechanism. Methylene blue increases the lifespan of cells. During the senescence process, cells stop dividing and essentially wither away. Methylene blue prevents this. This is critical to keeping all tissues regenerating and healthy, especially in the skin. So, in summary, methylene blue: ⬨ REVERSES aging in 80+ year old cells, returns them to a state of a 30 year old ⬨ PREVENTS skin cell death ⬨ INCREASES skin cell numbers ⬨ INCREASES the functioning and thickness of the dermis layer ⬨ STIMULATES the production of collagen ⬨ PROTECTS the collagen producing cells from death ⬨ PROMOTES wound healing ⬨ PROTECTS against UV damage to skin cells ⬨ EXTENDS lifespan in animals ⬨ BOLSTERS mitochondrial function ⬨ PREVENTS the natural decay of cells What more could you ask for?
8
20
2
144
7,444
Methylene Blue retweeted
NEW CLINICAL TRIAL RESULT: NMN suppresses harmful antibody-driven immune attacks to alleviate a common bleeding disorder. Authors suggest it may help other autoimmune diseases like lupus and rheumatoid arthritis 🙏🧵
19
80
4
666
49,466
Methylene Blue retweeted
More is NOT always better. Methylene Blue operates on a steep "hormetic" curve: at low micro-doses (10-20mg), it acts as a profound cellular supercharger that bypasses broken enzymes to keep your energy turbine spinning. But take too much, and it flips from a protector to a toxin. Learn the "sweet spot" for cognitive enhancement and why precision is the only way to hack your mitochondria. Episode link in bio. #methyleneblue #biohacking #hormesis #energy
1
6
259
Methylene Blue retweeted
Age reversal is natural
22
128
14
1,031
576,677