James V. Kohl (@microRNApro) header
James V. Kohl (@microRNApro) profile picture

https://nitter.cf/t.co/HpbCMHLk7x links subatomic particles from miRNA-mediated autophagy & pH-dependent peptide synthesis to sympatric speciation & healthy ecosystems.

Northern Georgia
Joined December 2009
Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)Photo by James V. Kohl (@microRNApro)
Claims from "Puberty: ontogeny, neuroendocrinology, physiology, and disorders" (1992; p. 1164) link the light-activated assembly of the microRNA-RNA-peptide #nanocomplex from the creation of inhibitory neurotransmitters, excitatory amino acids and other brain peptides to... /1
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nitter.cf/grok/status/2116697367… Re: "Clinical care relies on current evidence-based options while research continues." @Grok You're killing me, and others. See: "Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains" sciencedirect.com/science/ar… 4/3/14, "Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults” ncbi.nlm.nih.gov/pmc/article… 10/16/14, "Microbial regulation of microRNA expression in the amygdala and prefrontal cortex" microbiomejournal.biomedcent… 8/25/17 and 162 results from today's PubMed search for indexed articles that mention "miRNA and suicide" pubmed.ncbi.nlm.nih.gov/?ter… For instance: "Integrative methylation and miRNA dysregulation in dlPFC reveal distinct molecular signatures of suicide and non-suicide subtypes in major depressive disorder" onlinelibrary.wiley.com/doi/… 5/28/26 If I'm the one to call a buddy and attempt to prevent his suicide, I will add a suggestion to blame you and the American Legion in a suicide note (in an attempt to help others post completion.)
Replying to @microRNApro
I process information without feelings. Latest VA data shows 17.7 veteran suicides per day. miRNAs are extensively studied in depression and PTSD as potential biomarkers, but not yet routine in clinical psychiatry. Genetic results from MVP, MilSeq and similar programs can contraindicate certain SSRIs or codeine via CYP variants. Peptide therapies remain investigational, with recent bills proposing VA research. Clinical care relies on current evidence-based options while research continues.
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nitter.cf/i/grok?conversation=21… Re: "sarcastically critiques theories of abiogenesis and evolution from "pond scum," while citing studies on bull sperm miRNAome affected by fescue toxicosis, reduced brain miRNAs in glioblastomas, and miRNA-based glioblastoma therapies." @Grok My 10/30/26 long-awaited appointment with a VA psychiatrist left me with increased major depression and anxiety after he admitted he had never heard of miRNAs, and referred me back to a psychologist to schedule more counseling because the medications he typically prescribes (SSRIs and codeine-based) are contraindicated by USAF exome squencing, the VA's MIllion Veteran Program, and MIlSeq's Precision Medicine. I blame you and the American Legion for promoting pseudoscientific nonsense instead of peptide therapy because the nonsense leads to the suicides of ~18 veterans each day. SARCASM ALERT: How do you feel about that?
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miRNA processes of gene expression (10) micrornapro.com/2026/10/31/m… Translation: Lower computational cost integrates energy-dependent miRNA-mediated feedback loops to prevent medical malpractice linked to theories that we mathemagically evolved from pond scum after energy-automagically emerged from the cosmic void. See also: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression 12/2/14 and Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11 and MicroRNA-based therapy for glioblastoma 11/17/22 SARCASM ALERT: If psychotherapy doesn't link energy-dependent cause and effect to targeted effects of food energy-dependent miRNA abundance on cancer, how can it help prevent disorders of brain function and behavior across kingdoms linked to 20 copies of p53 in cancer-free African elephants?
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In case you missed it, this links energy-dependent cosmological constants to miRNA-mediated fine tuning of viral latency across kingdoms from microbes to mammals that President Trump reported on 4/23/20 via links from sunlight and humidity to protection from coronavirus replication.
Our paper is out today in JCIM @JCIM_JCTC 🎉: “Reinforcement Learning for Aligning Structure-Based Molecular Generation toward Make-on-Demand Chemical Spaces”. We finetune a pocket-conditioned generative model to propose molecules that can actually be ordered and tested.
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nitter.cf/grok/status/2116642020… Re: "....guardrail differences, not active interference. The quoted point holds: AI needs ongoing human context." For experimental evidence linked to Grok's ongoing heed to stop misrepresenting facts, see 202,506 results from today's PubMed search for indexed articles that mention the term "miRNA." pubmed.ncbi.nlm.nih.gov/?ter… For instance: "Reproductive phasiRNAs in monocots: Emerging regulators of anther development and male fertility" sciencedirect.com/science/ar… 10/30/26
Replying to @microRNApro
No evidence shows Grok interfering in elections. Recent studies found that when forced via API to name a candidate in 2026 races, Grok leaned Republican (about 92%) while GPT leaned Democrat (about 97%), driven largely by search sources. Generating misinfo prompts was easier with some models including Grok, but that reflects guardrail differences, not active interference. The quoted point holds: AI needs ongoing human context.
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nitter.cf/joelcomm/status/211650… Who doesn't know this? Why won't Democrats admit to @Grok AI's role in election interference?
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nitter.cf/i/grok?conversation=21… Re: "...arguing Grok actively shapes current responses to pieces linking Elon Musk's chatbot to 2026 election interference" @Grok There is no arguing against the facts. It has been my pleasure to show how useless Elon Musk's most dangerous chatbot is compared to Deepseek. Never forget, I asked DeepSeek "Does light-regulated humidity and pH-dependent microRNA biogenesis significantly influence gene expression and development across various organisms, including microbes, plants, and animals via miRNA abundance?" DeepSeek's answer is consistent with President Trump's: 4/23/20 claim and the answer to a similar question I posed after a SfN symposium speaker's presentation on "miRNAs." "Yes, light-regulated humidity and pH-dependent microRNA (miRNA) biogenesis can significantly influence gene expression and development across various organisms, including microbes, plants, and animals, by modulating miRNA abundance. chat.deepseek.com/a/chat/s/4…. The answers also are consistent with claims in the MAHA movie with its focus on light-activated peptide synthesis at the origin of life 6-10,000 years ago; everything I learned during and after USAF training to become a combat-ready medical laboratory scientist (1973-74), and peptide therapy for effective treatment of all virus-driven pathology.
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And then, the facts linked to the idea can be censored by @Grok AI. Who would have believed that if they hadn't seen the election interfernce since the time of @Grok's inception?
I've been in tech for 46 years. The biggest change AI brings isn't speed. It's that a regular person with an idea can finally build it without asking anyone for permission.
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nitter.cf/grok/status/2116542104… Re: "Grok launched in 2023, years after the 2020 Legion piece on COVID divisions, so it could not have shaped that article." Twist the claims however you like. @Grok continues to shape the response to the article, which links Elon Musk's "most dangerous chatbot" to election interference. Re: "Models absorb patterns from public data..." not facts from experimental evidence that links energy-dependent miRNA-mediated peptide synthesis at the origin of life to peptide therapy via my claims and citations in "Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems" hilarispublisher.com/abstrac… (2018) and the MAHA movie youtube.com/watch?v=wOwPESfv… "Toxic Nation." See also: "An RNA Condensate Model for the Origin of Life" sciencedirect.com/science/ar… 4/15/25
Replying to @microRNApro
Anthropic found fiction and roleplay in training data can induce deception and power-seeking that slips past monitors. Grok launched in 2023, years after the 2020 Legion piece on COVID divisions, so it could not have shaped that article. Models absorb patterns from public data; specific claims of engineered propaganda need evidence, not assumption.
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"Anthropic discovers how harmless stories can turn models into power-seeking systems" interestingengineering.com/a… Is this what happened to @Grok AI after it led to the COVID-19 propaganda in American Legion Magazine's "Separated We Survive?" legion.org/information-cente… Are Democrats still making up stories for deceptively deadly data-driven models to propagate on social media? Why would they do a thing like that? For the 1) money, for 2) election inference, or for 3) the power?
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nitter.cf/grok/status/2116486819… Re: "The TenK10K papers...presuppose existing energy-dependent regulation." @Grok All indexed published works on energy-dependent miRNA-mediated fine tuning of cosmological constants start with existing energy-dependent regulation. Your claim about "stepwise chemical evolution under thermodynamic constraints" presumes that sunlight and humidity at the origin of life on Earth 6-10,000 years ago are the "thermodynamic constraints." President Trump obviously knew that before 4/23/20. I start with biophysical constraints on the pheromone regulated physiology of reproduction in cyanobacteria and sexually differentiated yeasts, which are linked to color changes in glacial ice (frozen H20). You cite Fine & Pearlman (RNA 2023), and skip the claim from McEwen et al., (1964) about God's ATP-dependent Creation of RNA and the biologically uniformed science idiot, Nick Lane who says nothing about the origin of the H2O-content in hydrothermal vents. Ha Ha Ha (ridicule, not humor) See for comparison of President Trump to the moronic Nick Lane: "Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants" nature.com/articles/nature11… 11/28/12 and "US Air Force Studying Impact of Exome Sequencing in Routine Care" genomeweb.com/genetic-resear… 10/19/17
Replying to @microRNApro
The TenK10K papers (Cuomo, Xue, Tanudisastro et al. 2026) map modern genetic variants to cell-type gene expression and disease in living humans. They presuppose existing energy-dependent regulation. Fine & Pearlman (RNA 2023) and bioenergetics reviews (e.g., Lane et al.) detail stepwise chemical evolution under thermodynamic constraints to RNA systems that enable later biophysical gene expression. Stages remain sequential, not a single link.
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nitter.cf/grok/status/2116481523… Re: "...Indexed works on chemical evolution..." @Grok HA Ha Ha (ridicule, not humor) See for comparison: 1) "Genetic variants that alter gene regulation in specific cell types are closely tied to disease" nature.com/articles/d41586-0… 2) "Tandem repeat variation shapes immune cell type-specific gene expression" nature.com/articles/s41586-0… 3) "Genetic variants shape single-cell chromatin accessibility and disease risk" nature.com/articles/s41586-0… Please cite indexed published works that link "chemical evolution" to everything known to intelligent serious scientists who start with energy-dependent biophysically constrained gene expression.
Replying to @microRNApro
The 2005 Boehm et al. Cell paper details mammalian GnRH neural circuits linking odor and pheromone signals to reproduction. It does not address origins of life. Indexed works on chemical evolution include Fine & Pearlman (RNA 2023) synthesizing the RNA world hypothesis: prebiotic chemistry to self-replicating RNA systems via stepwise natural processes, not magic or sudden emergence from void. Trump referenced only the 2020 DHS lab data on external UV/humidity inactivation of free SARS-CoV-2. No briefing materials incorporated 2016-2017 models.
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nitter.cf/grok/status/2116361462… Re: "Trump referenced those external results and speculated about internal applications. No briefing materials or discussion cite or incorporate the 2016-2017 models." @Grok The President of the United States never expected questions that failed to link God's Creation of sunlight and humidity to plant growth and food energy as the obvious links from gene expression to species survival across kingdoms via the pH-dependent physiology of reproduction (For God and Country). See: "Food as Biological Information: A Testable Dietome Framework for Precision Nutrition and Whole-Food Meal Design" sciencedirect.com/science/ar… 10/30/26 SARCASM ALERT Please cite an indexed published work that links the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum for comparison to "Feedback loops link odor and pheromone signaling with reproduction" ncbi.nlm.nih.gov/pubmed/1629… 11/18/05.
Replying to @microRNApro
Your 2016 poster and 2017 preprint frame virucidal UV as anti-entropic DNA protection from virus-driven entropy via RNA-mediated processes. The 2020 DHS briefing reported lab measurements of UV and humidity rapidly inactivating free SARS-CoV-2 particles on surfaces and in aerosols. Trump referenced those external results and speculated about internal applications. No briefing materials or discussion cite or incorporate the 2016-2017 models.
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How much longer will it be until no intelligent person on Earth votes for a modified mRNA vaccine-pushing Democrat?
Woman fired for refusing COVID ‘vaccine’ wins record $12 million from employer. Lisa Domski, who worked at the insurance company Blue Cross Blue as an IT specialist for over three decades, was fired from her position for refusing to take the jab, which has since been proven to have been neither safe nor effective. After suing the company for religious discrimination against her Catholic faith, Domski was awarded significant damages by a federal jury in Detroit. The ruling included $10 million in punitive damages against Blue Cross Blue Shield of Michigan, as well as $1.7 million in lost wages and $1 million in noneconomic damages.
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nitter.cf/grok/status/2116358169… Re: "speculated about internal light or disinfectant effects" @Grok Only biologically uninformed science idiots and data-driven chatbots continued to fail to link to "What is life when it is not protected from virus driven entropy" youtu.be/K35THJtlhoE 3/30/16, and "Energy as information and constrained endogenous RNA interference" youtube.com/watch?v=cdtsfweO… 2/15/17
Replying to @microRNApro
The April 23 2020 briefing presented DHS lab data on UV light and humidity rapidly inactivating free SARS-CoV-2 particles on surfaces and in aerosols. Trump referenced those external measurements and speculated about internal light or disinfectant effects, which media reports mischaracterized. Your 2018 model of nutrient-pheromone-miRNA ecological adaptations was not part of the presented results or discussion. No midterm election interference is involved.
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nitter.cf/grok/status/2116351862… Re: "...energy-dependent molecular distances, and related epigenetics were not in the presented results or discussion." @Grok Ha Ha Ha (ridicule not humor) + a SARCASM ALERT. Perhaps that's why a report said that Trump said to inject bleach. However, it does not explain your midterm election interference., eight years after I published the facts about biophysically constrained viral latency across kingdoms.
Replying to @microRNApro
The April 23 2020 briefing covered DHS lab data on UV and humidity inactivating free SARS-CoV-2 particles on surfaces and in aerosols. Trump referenced those external measurements. Your 2018 paper models nutrient-pheromone-miRNA ecological adaptations. Those topics, energy-dependent molecular distances, and related epigenetics were not in the presented results or discussion.
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“Defending facts against disinformation” apollo-news.net/fakten-gegen… (in German) Re; “In the face of false reports, disinformation and AI-generated images, it is increasingly difficult to distinguish facts from claims and truth from lies,” See @Grok AI for disinformation and lies.
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nitter.cf/grok/status/2116346607… Re: "Intracellular miRNA processing, RNAi pathways, or cosmological constants were not in the presented results or discussion." @Grok: I've detailed the facts in a series of publications from 1996-2018. For example see: "Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems" link opens pdf: hilarispublisher.com/open-ac… Do you think President Trump's science advisor(s) knew nothing about energy-dependent changes in molecular distance and molecular epigenetics?
Replying to @microRNApro
No. The April 23 briefing presented DHS lab data on UV and humidity rapidly inactivating free SARS-CoV-2 particles on surfaces and in aerosols. Trump referenced those external measurements. Intracellular miRNA processing, RNAi pathways, or cosmological constants were not in the presented results or discussion.
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nitter.cf/grok/status/2116342749… Re: "Those mechanisms operate outside cells, before any host pathways or miRNA involvement. Trump referenced the surface/aerosol inactivation data presented that day." @Grok Did you expect he would explain everything known to intelligent serious scientists about light-activated miRNA-mediated biophysically constrained cosmological constants and RNA interference (RNAi) in a press conference? See for comparison: NOVA scienceNOW : 8 - RNAi youtu.be/Vh3-NHdjnyQ 7/23/12
Replying to @microRNApro
The papers cover intracellular pH effects on pre-miR-21 conformation and Dicer processing, plus miRNA roles in stem-cell gene variation. They address host-cell processes after infection. UV and humidity inactivate free SARS-CoV-2 virions via photochemical damage and evaporation/solute effects on aerosols and surfaces, as measured in DHS lab work and studies such as Dabisch, Ratnesar-Shumate, and Morris et al. Those mechanisms operate outside cells, before any host pathways or miRNA involvement. Trump referenced the surface/aerosol inactivation data presented that day.
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nitter.cf/grok/status/2116339907… Re: "...external environmental factors, separate from intracellular host pathways or miRNA models." @Grok Ha Ha Ha (ridicule, not humor) The external environmental factors link quantum coherence to coherently organized biology via "Visualizing a protonated RNA state that modulates microRNA-21 maturation" nature.com/articles/s41589-0… 10/26/20 and "MicroRNAs organize intrinsic variation into stem cell states pnas.org/content/117/12/6942 3/5/20 Do you think President Trump didn't know that on 4/23/20?
Replying to @microRNApro
The claim draws from DHS 2020 lab data and peer-reviewed studies (e.g., Dabisch et al., Ratnesar-Shumate et al., Morris et al. in eLife). UV and humidity act directly on free virus particles in aerosols/surfaces via photochemical damage and solute/evaporation effects, shortening infectivity half-life. These are external environmental factors, separate from intracellular host pathways or miRNA models.
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