@moorlab
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Laboratory of Systems Physiology at @ETH_BSSE, aka SyPhy lab! Spatial transcriptomics, niche interactions, RNA localization. Tweets are from lab members ✌️
D-BSSE at ETH Zurich, CH
Joined October 2019
- Tweets143
- Following354
- Followers994
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Check out our lab's latest paper out in @Nature! Congrats to @cocoborrelli and everybody involved 🎉🥳
How are cell-cell interactions governing successful metastatic colonization in the liver? Have a look at our new paper in @nature that introduces an in vivo proximity screen to functionally test cellular interactions in a high-throughput manner. nature.com/articles/s41586-0… 🧵
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Researchers at ETH Zurich have uncovered how #Colorectal #CancerCell's colonise the liver. Their findings could open up new ways to suppress this process in the future. brnw.ch/21wLtkS @ETH_BSSE
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My PhD work in the @moorlab is out 🥳🤩🤪 Five year after that lunch break discussion with @AndreasMoor! Thanks Andreas for believing in our crazy outside-in screen and to ALL the people that helped along the way!
Nature research paper: In vivo interaction screening reveals liver-derived constraints to metastasis go.nature.com/3YjMsnM
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Next week check in again, same space, same time: more in vivo screening to come from the @moorlab ☺️🚀
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Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵
nature.com/articles/s41586-0…
Stop stressing about losing granulocytes in your single-cell RNA seq experiment and check out our new protocol online now at @NatureProtocols 🧘♂️ with @AlessandraGurt1 @lab_arnold @moorlab
nature.com/articles/s41596-0…
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Well, this is what happens when two scientists become best friends (@cocoborrelli) and go on a relaxing retreat to a beautiful island in gulf of Naples with delicious mozzarella and wine... They make science!
embopress.org/doi/full/10.10…
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ISCHIA uses the inherent proximity of #spatialtranscriptomics spot data to reconstruct co-occurring cell-type networks. Application to ulcerative colitis patient data reveals #inflammation-induced cellular networks ➡️ embopress.org/doi/full/10.10… @AndreasMoor @moorlab @ETH_BSSE
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ISCHIA is online at @MolSystBiol! So much fun to work with the one and only @Ati_lz! Takeaway message from this project: lab retreats are fun and inspirational, even if no scientific activity is planned! Keep it up @moorlab!
embopress.org/doi/full/10.10…
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Great work by @handlerkristina !
New method to understand cell-cell communications | In a study published by @NatureComms, researchers from the Systems Physiology lab of Andreas Moor @moorlab, developed a method to characterise microenvironments at single-cell resolution > u.ethz.ch/Gm9Jg
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Check out the three open positions for Assistant Professors TT at our department in Basel
> bsse.ethz.ch/department/open… Please share! @ETH_en
#Biomedicine #Biodata #Genomics #Bioengineering #jobopportunity
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@moorlab moved to the new @ETH_BSSE building from today :)! looking forward to interacting with @biozentrum more 👩🔬👨🔬
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Excited to give a talk about our recent work from the sendoel-lab at #KSSingleCell23 @KeystoneSymp tomorrow.
"Tissue-wide Single-cell CRISPR Uncovers Distinct TNFa Modes in Clonal Expansion and Transformation in the Skin".
In collaboration with @moorlab and @s__ellis
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Very innovative approach, cool results, excellent science with important putative implications - simply a pleasure to read. Congratulations !!
Soooo happy to share the results of my PhD project in the @moorlab! The seed and soil hypothesis postulates that metastases will only grow in favorable environments. Here we forget about the seed and focus on the soil. Which factors in the liver promote or suppress seeding? 🧵👇
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Soooo happy to share the results of my PhD project in the @moorlab! The seed and soil hypothesis postulates that metastases will only grow in favorable environments. Here we forget about the seed and focus on the soil. Which factors in the liver promote or suppress seeding? 🧵👇
In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis biorxiv.org/cgi/content/shor… #bioRxiv
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Super excited about this new preprint of the lab 🚀🚀. Congrats to @cocoborrelli and all coauthors. Our research delves into the world of tumor-hepatocyte interactions, spotlighting #PlexinB2 as a key player in regulating liver metastasis.
Soooo happy to share the results of my PhD project in the @moorlab! The seed and soil hypothesis postulates that metastases will only grow in favorable environments. Here we forget about the seed and focus on the soil. Which factors in the liver promote or suppress seeding? 🧵👇
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Thanks @AshleyMaynard10 and organizers for the invitation! Such an inspiring day so far, loving this conference , the people and the venue.
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Next up is @AndreasMoor talking about cancer organoids and drug development. They are profiling cancer heterogeneity driven aberrant signaling and interactions in primary cancer tissue and colon cancer #organoids using spatial transcriptomics @ETH_BSSE
New research from our collaboration with the Boyman lab at @UZH_ch now published in @NatImmunol: rdcu.be/daYti! Check it out to learn about memory B cell plasticity, longitudinal tracking of B cell clones and much more performed by @ZurbuchenY and @JanMichler! Digest:🧵
[5] Using our scRNAseq data, we characterized the transcriptional makeup of different S+Bm cell subsets in great detail. Main result: CD21–CD27–S+ Bm cells carried a distinct transcriptional profile, similar to ‘atypical’ B cells found in chronic infection and autoimmune disease.
