Head and neck cancer surgeon and scientist, mother of 3 boys. My lab studies intratumoral bacteria and RNA vaccines in head and neck and endocrine cancers.
Cleveland, OH
Joined August 2022
- Tweets261
- Following563
- Followers371
- Likes1.2K
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
Presented by the AHNS Annual Basic & Translational Science Service. Prepared by @MollyEHeftNeal and @basulab1, this infographic explores HPV/p16 discordance in oropharyngeal cancer, its prognostic & therapeutic relevance, and implications for confirmatory HPV testing.
#AHNS
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
So proud of the huge efforts led by @moranamit2 to help unlock the biology of non-melanoma #skincancer in immunosuppressed patients! @ShorookNa #OncSurgery @MDAndersonnews 🗞️
Cell cell.com/cell/fulltext/S0092…
Thrilled to share that my R01 has been converted to an NCI R37 MERIT Award! This award will support our work on intratumoral bacteria and the tumor immune microenvironment in oral cancer. Grateful to the NCI, my mentors, collaborators and lab/clinical teams.
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
Brain cancers are among the most lethal and biologically complex forms of the disease. We are grateful to the #AACRbrain26 cochairs for convening leading experts from academia, industry, and the clinic to catalyze new scientific partnerships and move the field forward.
As we adjourn the AACR Special Conference on Brain Cancer, we thank #AACRbrain26 cochairs @StephenBagleyMD, @Michelle_Monje, and @MarioSuva, invited speakers, and abstract presenters for their contributions to this outstanding program.
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
Great @bikeVeloSano captain kickoff event! Exciting research updates from the group including @OConnorVirusLab and Natalie Silver - looking forward to another great year 🚴♂️
My superstar post-doc Kala Mahen showed up to TRCCC with an adorable new addition! I think baby Cameron will be a future scientist! 😉
Honored to present our work on intratumoral bacteria in head and neck cancer at #TRCCC2026. What a great meeting!.
Awesome presentation by @nataliesilvermd at #TRCCC2026 on intratumoral bacteria in head and neck cancer, including early results from her clinical trial showing in HNSCC showing:
✅successful reduction of bacteria in patients
✅improved infiltration of T cells
@CCLRI @caseccc
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
Thanks for the great write up Andreas!
📢 Not all head and neck cancers are equal. Some are colonised by bacteria, dictating the response to immunotherapy.
Read about past, present and future research on the tumour microbiome with input from @McGrailResearch in the article below 👇
open.substack.com/pub/breaki…
Had a great time at the University of Pittsburgh Department of Otolaryngology–Head & Neck Surgery Grand Rounds sharing our work on intratumoral bacteria in head and neck cancer. Great connecting with colleagues and friends. Thank you for the invitation!
More amazing team science to kick off 2026! Check out our publication, led by @McGrailResearch on NLR in diverse patient populations. @ClevelandClinic @caseccc
Thanks for highlighting our study! Excited to share our work in @jclinicalinvest showing how biomarkers such as NLR can vary by patient demographics. @nataliesilvermd @DrAlexAdjei @lucmorrisnyc
A great summary of our recently published paper by my research partner @McGrailResearch.
A focus as we started our lab @ClevelandClinic was to understand cancer-type dependent drivers of ICI response. In our paper published in @NatureCancer with @nataliesilvermd, we show how bacteria can drive ICI resistance in head and neck cancers. (1/N) nature.com/articles/s43018-0…
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
🥳🎆 Kicking of 2026 with our work showing intra-tumoral bacteria 🦠 affect outcomes of Radiotherapy + anti-PD-L1 now out in @NatureCancer with sister paper by @nataliesilvermd! Even when trials "fail" – we can learn from them! nature.com/articles/s43018-0…. -- w/ @GeneCollector, @imrtlee, @TylerAlban1, @DrHaddadRobert, the Pfizer team and more! (1/N)
Thank you Nature Cancer for highlighting our work! @GeneCollector @TylerAlban1 @xrtGenomics @DrNeilGross @CleClinicNews @ClevelandClinic
🎆New year, new papers at Nature Cancer!
The amount of tumor bacteria is now shown to influence immunotherapy outcomes in head and neck cancer in two papers out today:
🔗nature.com/articles/s43018-0…
🔗nature.com/articles/s43018-0…
With the associated N&Vs:
nature.com/articles/s43018-0…
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
Amazing body of work! Stellar example if team science! Congrats to @xrtGenomics & @nataliesilvermd
Two papers in @NatureCancer highlighting the role of intratumoral bacteria & associated immune architecture (e.g., neutrophil influx) in mediating resistance to immunotherapy in head & neck cancer.
nature.com/articles/s43018-0…
nature.com/articles/s43018-0…
@GeneCollector @xrtGenomics
Thrilled to share our paper published in Nature Cancer, alongside the JAVELIN-100 sister study. Our work identifies intratumoral bacterial burden as a key determinant of immunotherapy response in HNSCC. Thanks to the team who made this possible.
🔗 nature.com/articles/s43018-0…
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
ZERO cases of cervical cancer diagnosed in women under age 25 in Australia 🇦🇺
None . Nada . Zip.
For the first time since records began!
How did this happen?
One word
VACCINES!!!!!
Natalie Silver MD, MS, FACS-DrSilverLab retweeted
Australia just recorded zero cervical cancer cases in women under 25 - for the first time since records began in 1982.
This is what happens when a country commits to HPV vaccination and screening. We protect our girls and save lives.
Thanks for visiting Cleveland Clinic @DrNeilGross and sharing your practice-changing work with us. From fellowship to present day, you continue to inspire us.
Great to be @ClevelandClinic for #headandneck #cancer research update and to see @MDAndersonNews former fellow ‘besties’ Dr. Jamie Ku and @nataliesilvermd crushing it! 🧬🩺
Amazing keynote presentation by @RobertFerrisMD at the Case Comprehensive Cancer Center Annual Retreat.
Amazing discovery from my UF research partner Elias Sayour and team.
How do mRNA vaccines help fight cancer?
A @nature publication today tells the story, one with big implications, as reviewed here @MDAndersonNews
@StevenLin_MDPhD @adam_grippin
erictopol.substack.com/p/how…
