∑ ∫: Assistant Professor {@unccs,@CompMedUNC}. // Single-Cell Bioinformatics. interested in how the immune system adapts in aging.Lab: @comp_cy
Durham, NC
Joined October 2011
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Natalie Stanley retweeted
Persistent and compartmentalized T cell immunity in ALS @NatureMedicine
nature.com/articles/s41591-0…
Natalie Stanley retweeted
CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @ImmunityCP
cell.com/immunity/fulltext/S… @maxim_artyomov @WashU @nikart89 @NationwideKids @KingsCollegeLon
Natalie Stanley retweeted
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury | Science Translational Medicine @ScienceTM science.org/doi/10.1126/scit…
Natalie Stanley retweeted
Blood proteomics of menopause map to brain aging and dementia risk
nature.com/articles/s41591-0…
Natalie Stanley retweeted
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy @NeuroCellPress cell.com/neuron/fulltext/S08…
Natalie Stanley retweeted
A paper in Nature presents the largest-known map of gene expression in the human prefrontal cortex region of the brain. go.nature.com/4yLUu82
ALT This is figure 1, which shows single-nucleus transcriptomic atlas of the human DLPFC across the lifespan.
Natalie Stanley retweeted
As we age, our blood quietly shifts toward making more inflammation-prone immune cells and fewer of the ones that fight infections and cancer well — real bad news in old age. This paper found one specific immune cell is secretly driving that shift, and blocking a single signal from it reversed the effect in old mice, restoring muscle strength too.
nature.com/articles/s43587-0…
Natalie Stanley retweeted
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration @NatureNeuro
nature.com/articles/s41593-0…
Natalie Stanley retweeted
Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence @NatureNeuro nature.com/articles/s41593-0…
Natalie Stanley retweeted
Single-cell transcriptomics provides insights into the stress-immune interplay and informs disease risk @CellGenomics
cell.com/cell-genomics/fullt… @UNC
Natalie Stanley retweeted
Celebrating new discoveries— Brain’s immune cells in seizures and epilepsy 🎉
My PhD dissertation paper out today — read more about this fascinating Microglia ion channel that reduces seizures severity, helps chow neurons, and surprising sex differences!
insight.jci.org/articles/vie…
Natalie Stanley retweeted
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.64898…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
Natalie Stanley retweeted
Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming @NatureNeuro
Natalie Stanley retweeted
Excited to share our RegVelo paper in Cell
cell.com/cell/fulltext/S0092…
We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬
Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏
Natalie Stanley retweeted
In this @ImmunityCP study, a single-cell immune aging clock identifies RUNX1 as a key regulator of T cell senescence and rejuvenation.
📄 Read the paper: bit.ly/49vm7rz
🎧 Listen to the discussion: bit.ly/4f2ci85
Natalie Stanley retweeted
Glad to have contributed to this work on a molecular census of human & mouse microglia, showing that these cells aren't fixed types, but are dynamic states shaped by their anatomical niche and disease context.
Now out in @NatImmuno 🧠 rdcu.be/e9WJb
Natalie Stanley retweeted
Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation
nature.com/articles/s41590-0…
Natalie Stanley retweeted
Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age nature.com/articles/s43587-0…
My PhD student Chi-Jane is graduating soon and looking for her next position. She is an expert in CyTOF and IMC analysis, especially :) she can help you to derive predictive immune signatures from your data 💻🧫chencookie.github.io/index.h…
