📌When should we treat ALT elevation after AAV gene therapy for haemophilia A?
We published the first biopsy-proven evidence of immune-mediated hepatitis after valoctocogene roxaparvovec. We propose a practical algorithm to manage post-gene therapy transaminase elevations.
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Niccolò Bitto retweeted
Evidence is mounting that blockbuster anti-obesity drugs might also curb alcohol cravings, and more. go.nature.com/3XT8NrM
Niccolò Bitto retweeted
#Quirinale: – at Roma, Lazio

ALT Il Presidente della Repubblica ha fatto presente al Ministro dell’Interno, trovandone condivisione, che l’autorevolezza delle Forze dell’Ordine non si misura sui manganelli ma sulla capacità di assicurare sicurezza tutelando, al contempo, la libertà di manifestare pubblicamente opinioni. Con i ragazzi i manganelli esprimono un fallimento.
Niccolò Bitto retweeted
Amica residente in USA con lieve polmonite post #Covid. Ecco il conto per 1 giorno in pronto soccorso, esami diagnostici e farmaci.
Teniamoci stretto e rilanciamo il nostro Servizio Sanitario Nazionale
RT 🙏
#SalviamoSSN
Chiusura asilo comunale Via Meleri a tempo indefinito da lunedì 8, comunicata via mail venerdì 5 sera: bambini (2/3 anni) spostati in asilo lontano e raggiungibile praticamente solo via macchina. Indecente, inammissibile soprattutto nei tempi e nei modi. @ComuneMI @milano_today
Niccolò Bitto retweeted
Residual burden of liver disease after #HCV clearance in hemophilia: a word of caution in the era of #gene therapy sciencedirect.com/science/ar…
Niccolò Bitto retweeted
See you in Milan next year!
@EASLnews
Niccolò Bitto retweeted
INTRAMOENIA
A scanso di spiacevoli equivoci, specifico che io sono infermiera e mai farò intramoenia, sia perché non è previsto per la mia professione, sia perché il mio tempo libero lo voglio usare per altro. Ma odio la grave disinformazione che circola sul tema!
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Niccolò Bitto retweeted
"Growth of your team members = Growth of yourself", I firmly believe in this statement. Definitely a must-read piece.
As a professor, pursue the careers of your PhD students and postdocs instead of pursuing your own.
I know it may sound strange and even provocative. But in fact it is how it’s supposed to be.
Unfortunately, a personal gain is the biggest motivation for many professors. More publications, more awards, more invited talks…
Why? In addition to personal recognition, it can result in more funding and higher salaries (especially in the U.S.).
Many PIs say that their personal growth also helps their students get a better visibility. Plus, more funding brings in more students, which is (kind of) “great” for those students.
Others will say that their “tenure requirements are too demanding” and if they stop focusing on personal gain, they will be denied tenure.
In either case, I want you to think about the following:
1. When we focus on personal achievements, we lose track of the wellbeing and personal preferences of team members. Although it often feels like we still track it, in fact we become far less efficient at it. Students' progress and personal development are impeded. Their career opportunities become less diverse or even missed.
2. Concentrating too much funding in one big lab is NOT a good idea because it leads to PhD students receiving far less mentorship and research advising (than in smaller labs).
3. Tenure requirements often look intimidating to young professors. However, in reality, very few professors are denied tenure. Why? First, because any university invest big resources into TT professors and don’t want get rid of them without a big reason. Second, because departments often exaggerate the tenure challenges to ensure their young hires are “hard-working faculties”.
Many PIs think I am too idealistic and propose unrealistic ideas. And a lot of people will never agree with this post. Even myself, I can easily come up with bitter criticism over it.
However, idealism is among the biggest driving forces. It can drive you through challenging times and help improve.
In either case, I want you to think about the following:
1. When we focus on personal achievements, we lose track of the wellbeing and personal preferences of team members. Although it often feels like we still track it, in fact we become far less efficient at it. Students' progress and personal development are impeded. Their career opportunities become less diverse or even missed.
2. Concentrating too much funding in one big lab is NOT a good idea because it leads to PhD students receiving far less mentorship and research advising (than in smaller labs).
3. Tenure requirements often look intimidating to young professors. However, in reality, very few professors are denied tenure. Why? First, because any university invest big resources into TT professors and don’t want get rid of them without a big reason. Second, because departments often exaggerate the tenure challenges to ensure their young hires are “hard-working faculties”.
My message is:
If we all pursue the careers of your students/postdocs in the first place, this shift in priorities will make academia a much better world to live in.
I see an increasing number of faculties trying to genuinely care for their team members, in all countries and academic environments. It is all possible. Just do it. Make science better.
Oh, and don’t forget:
Growth of your team members = Growth of yourself.
#AcademicTwitter #research #phdlife
Niccolò Bitto retweeted
Beethoven's DNA
cell.com/current-biology/ful… Identified hepatitis B and other risks for liver disease, no genetic explanation for hearing loss
@CurrentBiology
washingtonpost.com/science/2…
Don't look up
#IPCC Synthesis Report is now available via the report microsite at
ipcc.ch/report/ar6/syr/
#ClimateChange #AR6
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Niccolò Bitto retweeted
#IPCC Synthesis Report is now available via the report microsite at
ipcc.ch/report/ar6/syr/
#ClimateChange #AR6
Niccolò Bitto retweeted
Incidence of bleeding and clotting events in patients with #cirrhosis:
🇺🇸 Overall 1.304.801 vs. 26.569 with cirrhosis
⬆️ Rate of bleeding: HR 3.02
⬆️ Rate of portal vein thrombosis: HR 18.46
⬇️ Other thrombosis: HR 0.82
🔝 ow.ly/YvlN50MPWbv
#livertwitter

























